Collagen Cross-link Formation and Lysyl Oxidase

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What percentage of the total protein of mammals does collagen constitute?

40 to 50%

60 to 70%

25 to 35% (correct)

15 to 20%

What is the primary structural component of tendons and cornea?

Type I collagen (correct)

Type III collagen

Type IV collagen

Type II collagen

Which type of collagen is primarily found in cartilaginous structures?

Type II collagen (correct)

Type III collagen

Type I collagen

Type IV collagen

What is the primary function of type IV collagen?

Providing mechanical support for cells Signup and view all the answers

What is the characteristic of type III collagen fibers?

High distensibility Signup and view all the answers

Which type of collagen is classified as fibril-associated collagen?

Type IX collagen Signup and view all the answers

Which enzyme oxidatively deaminates lysine and hydroxylysine residues in collagen?

Lysyl oxidase Signup and view all the answers

What is a characteristic feature of skin in Ehlers-Danlos syndrome?

Skin hyperextensibility Signup and view all the answers

Which type of collagen is most commonly defective in the classic form of Ehlers-Danlos syndrome?

Type V collagen Signup and view all the answers

What is the primary function of elastin in connective tissue?

Maintaining tissue elasticity Signup and view all the answers

What is the main characteristic of osteogenesis imperfecta?

Bone fragility Signup and view all the answers

Which of the following is NOT a clinical manifestation of Ehlers-Danlos syndrome?

Muscle weakness Signup and view all the answers

What is the primary function of elastin in the extracellular matrix?

To allow for elasticity and flexibility in connective tissue Signup and view all the answers

What is the underlying cause of osteogenesis imperfecta?

Genetic mutations in the synthesis of collagen Signup and view all the answers

Which of the following is a characteristic of collagen?

It is the most abundant protein in the human body Signup and view all the answers

What is the name of the group of genetic disorders caused by defects in specific components of proteoglycans?

Mucopolysaccharidoses Signup and view all the answers

Ehlers-Danlos syndrome is a connective tissue disorder characterized by?

Hyperextensible skin and joint hypermobility Signup and view all the answers

What is the primary function of fibronectin in the extracellular matrix?

To facilitate cell signaling and adhesion Signup and view all the answers