18 Questions
What percentage of the total protein of mammals does collagen constitute?
25 to 35%
What is the primary structural component of tendons and cornea?
Type I collagen
Which type of collagen is primarily found in cartilaginous structures?
Type II collagen
What is the primary function of type IV collagen?
Providing mechanical support for cells
What is the characteristic of type III collagen fibers?
High distensibility
Which type of collagen is classified as fibril-associated collagen?
Type IX collagen
Which enzyme oxidatively deaminates lysine and hydroxylysine residues in collagen?
Lysyl oxidase
What is a characteristic feature of skin in Ehlers-Danlos syndrome?
Skin hyperextensibility
Which type of collagen is most commonly defective in the classic form of Ehlers-Danlos syndrome?
Type V collagen
What is the primary function of elastin in connective tissue?
Maintaining tissue elasticity
What is the main characteristic of osteogenesis imperfecta?
Bone fragility
Which of the following is NOT a clinical manifestation of Ehlers-Danlos syndrome?
Muscle weakness
What is the primary function of elastin in the extracellular matrix?
To allow for elasticity and flexibility in connective tissue
What is the underlying cause of osteogenesis imperfecta?
Genetic mutations in the synthesis of collagen
Which of the following is a characteristic of collagen?
It is the most abundant protein in the human body
What is the name of the group of genetic disorders caused by defects in specific components of proteoglycans?
Mucopolysaccharidoses
Ehlers-Danlos syndrome is a connective tissue disorder characterized by?
Hyperextensible skin and joint hypermobility
What is the primary function of fibronectin in the extracellular matrix?
To facilitate cell signaling and adhesion
Test your knowledge about the process of cross-link formation in collagen, including the role of lysyl oxidase, a copper-containing enzyme that oxidatively deaminates lysine and hydroxylysine residues. Learn how the reactive aldehydes formed can condense with neighboring collagen molecules to form covalent cross-links.
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