Podcast
Questions and Answers
What is the result of a deficiency of Protein C or S?
What is the result of a deficiency of Protein C or S?
Which of the following is a characteristic of a mutated Factor V?
Which of the following is a characteristic of a mutated Factor V?
What is the pattern of inheritance of a deficiency of Factor VIII or IX?
What is the pattern of inheritance of a deficiency of Factor VIII or IX?
What is the result of a deficiency of Antithrombin?
What is the result of a deficiency of Antithrombin?
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What is the diagnostic test result for a deficiency of Factor VIII or IX?
What is the diagnostic test result for a deficiency of Factor VIII or IX?
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What is the presentation of Deep Tissue Bleeding?
What is the presentation of Deep Tissue Bleeding?
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What is the primary mechanism of action in ITP that leads to thrombocytopenia?
What is the primary mechanism of action in ITP that leads to thrombocytopenia?
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Which of the following statements is true about Von Willebrand factor?
Which of the following statements is true about Von Willebrand factor?
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What is the characteristic of bleeding in Hemophilia A?
What is the characteristic of bleeding in Hemophilia A?
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What is the primary cause of hemolytic anemia in DIC?
What is the primary cause of hemolytic anemia in DIC?
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Which of the following is a characteristic of ITP?
Which of the following is a characteristic of ITP?
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What is the role of endothelium in DIC?
What is the role of endothelium in DIC?
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Which of the following is NOT a characteristic of Hemophilia A?
Which of the following is NOT a characteristic of Hemophilia A?
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What is the primary mechanism of action in DIC?
What is the primary mechanism of action in DIC?
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Study Notes
Platelet Disorders
- Immune Thrombocytopenic Purpura (ITP): Weak platelet plug leading to superficial bleeding due to autoimmune process, resulting in increased destruction of platelets.
- Mechanism of action: Autoantibodies against platelet receptors, leading to platelet destruction by macrophages in the spleen, causing thrombocytopenia.
Von Willebrand Factor Disorder
- Weak platelet plug leading to superficial bleeding due to impaired platelet function, caused by a deficiency of Von Willebrand Factor.
- Mechanism of action: Low amount of Von Willebrand Factor, impairing platelet adhesion to collagen, leading to superficial bleeding with normal platelet count.
- Additional effect: Decreased factor VIII, causing prolonged PTT.
Coagulation Disorders
- Hemophilia: Insufficient production of fibrin mesh, leading to deep tissue bleeding.
- Mechanism of action: Deficiency of factor VIII (Hemophilia A) or factor IX (Hemophilia B), leading to reduced fibrin production and deep tissue bleeding.
Mixed Disorders
- Disseminated Intravascular Coagulation (DIC): Widespread activation of platelets and coagulation factors, leading to excessive clotting and bleeding.
- Mechanism of action: Proinflammatory cytokines damage endothelium, releasing tissue factor and Von Willebrand Factor, leading to widespread clot formation, organ ischemia, and hemolytic anemia.
- Later stages: Consumption of platelets and fibrin leads to bleeding.
Inherited Thrombophilia
- Deficiency of Protein C or S, leading to unregulated clotting.
- Deficiency of Antithrombin, leading to unregulated clotting.
- Mutated Factor V, leading to resistance to Protein S or C, causing excessive clotting.
Patterns of Inheritance
- Autosomal Dominant: Inherited thrombophilia affects both men and women, with a single inherited gene.
- X-Linked Disorder: Hemophilia affects mostly males, in all ethnic groups, with females as carriers.
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Description
This quiz covers different types of coagulation disorders, including platelet disorders, coagulation factor disorders, and mixed disorders. Learn about the causes and symptoms of each type.
