Coagulation Cascade Quiz: Thrombin Burst and Clot Stabilization

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What is the primary function of Antithrombin III in the coagulation cascade?

Activate platelet aggregation

Enhance fibrin polymerization

Stabilize the fibrin clot

Inhibit factor IIa, Xa, and other coagulation factors (correct)

How does Heparin exert its anticoagulant action?

By inhibiting factor IIa and Xa (correct)

By activating platelets

By enhancing the activity of protein C

By stabilizing the fibrin clot

Which natural anticoagulant is produced by the liver to inhibit factors V & VIII activity?

Heparin

Protein S

Antithrombin III

Protein C (correct)

Which autocrine-paracrine mediator promotes vasodilation and inhibits platelet activation?

Prostacyclin Signup and view all the answers

What is the primary function of Tissue Factor Pathway Inhibitor (TFPI) in the coagulation cascade?

Inhibit extrinsic Tenase complex Signup and view all the answers

Why is Protein S important in the regulation of blood clotting?

Activates protein C Signup and view all the answers

What is the role of anticoagulant agents in preventing insult from developing thrombi or dislodging emboli?

Blocking steps in coagulation Signup and view all the answers

Which type of anticoagulant agent directly binds to thrombin to inhibit its function?

Direct thrombin inhibitors Signup and view all the answers

What is the mechanism of action of Vitamin K inhibitors in the context of coagulation?

Blocking the coagulative profile of Vitamin K dependent factors Signup and view all the answers

In fibrinolysis, what is the role of tissue plasminogen activator (t-PA)?

Activating plasminogen into plasmin Signup and view all the answers

Which of the following is NOT a target for digestion by the non-specific protease plasmin during fibrinolysis?

Factor V Signup and view all the answers

What is the main outcome of fibrinolysis in terms of blood vessels blocked by a clot?

Complete dissolution of the fibrin clot Signup and view all the answers

Which of the following is a natural anticoagulant present in plasma?

Antithrombin III Signup and view all the answers

Which enzyme is responsible for digesting and lysing fibrin clots?

Plasmin Signup and view all the answers

Which of the following agents inhibits the action of vitamin K, thereby reducing the production of clotting factors?

Warfarin Signup and view all the answers

Which of the following agents directly inhibits the action of thrombin?

Rivaroxaban Signup and view all the answers

Which of the following agents inhibits the action of factor Xa, thereby preventing thrombin generation?

Apixaban Signup and view all the answers

Which of the following mediators secreted by endothelial cells has potential anticoagulant action?

Nitric oxide (NO) Signup and view all the answers