Coagulation Cascade and Clot Formation Quiz
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Questions and Answers

What is the role of thrombin burst in the coagulation cascade?

  • Increasing formation of plasmin and activating protein C
  • Inhibiting factors IIa, Xa, and other coagulation factors
  • Promoting vasodilation and inhibiting platelet activation
  • Activating XIII for cross-linking fibrin into polymers (correct)
  • Which natural anticoagulant inhibits factors IIa, Xa, and other coagulation factors?

  • Antithrombin III (correct)
  • Protein S
  • Protein C
  • Heparin
  • What prevents clot extension once formed by inhibiting the extrinsic Tenase complex?

  • Prostacyclin
  • Heparin
  • Nitric oxide
  • Tissue-Factor Pathway Inhibitor (TFPI) (correct)
  • Which autocrine-paracrine mediator secretes nitric oxide to inhibit platelet adhesion and aggregation?

    <p>Prostacyclin</p> Signup and view all the answers

    What is the function of protein S in the clotting process?

    <p>Inhibiting factors V &amp; VIII activity</p> Signup and view all the answers

    Which of the following is NOT a mechanism by which anticoagulant agents can block steps in coagulation?

    <p>Platelet activation by releasing tissue plasminogen activator</p> Signup and view all the answers

    Which enzyme plays a key role in the process of fibrinolysis by causing the complete dissolution of the fibrin clot?

    <p>Plasmin</p> Signup and view all the answers

    In the context of blood clot dissolution, what is the role of tissue plasminogen activator (t-PA)?

    <p>Conversion of plasminogen to plasmin</p> Signup and view all the answers

    Which type of inhibitor blocks coagulation by directly binding to thrombin?

    <p>Direct thrombin inhibitors</p> Signup and view all the answers

    What is the function of factor X inhibitors in preventing clot extension?

    <p>Interfere with factor X activation</p> Signup and view all the answers

    What is the main role of the clotting factors circulating in the blood vessels?

    <p>To remain inactive until an injury occurs</p> Signup and view all the answers

    Why is the speed of blood flow important in preventing activation of clotting factors?

    <p>To prevent clotting factors from coming in contact with TF</p> Signup and view all the answers

    What is the function of endothelial cells in preventing clot formation?

    <p>To secrete mediators with potential anticoagulant action</p> Signup and view all the answers

    How does the glycoprotein coat on circulating platelets contribute to preventing clot formation?

    <p>It provides repulsion forces preventing sticking to healthy endothelium</p> Signup and view all the answers

    Which component of plasma contributes to preventing coagulation?

    <p>Natural anticoagulants like anti-thrombin III and heparin</p> Signup and view all the answers

    What is the purpose of the Fibrinolytic Phase in haemostasis?

    <p>To prevent uncontrolled extension of thrombus or its embolization.</p> Signup and view all the answers

    What regulates the Immediate Constriction Phase in haemostasis?

    <p>Nervous reflex induced by existing pain of injury.</p> Signup and view all the answers

    Which process converts soluble fibrinogen into an insoluble fibrin fiber during haemostasis?

    <p>Blood Coagulation Phase.</p> Signup and view all the answers

    What do Coagulation Factors mainly belong to in the context of haemostasis?

    <p>Plasma proteins.</p> Signup and view all the answers

    Which enzyme catalyzes the decarboxylation of Vit K-dependent Coagulation Factors in haemostasis?

    <p>Vitamin K.</p> Signup and view all the answers

    What is the main purpose of the Immediate Constriction Phase in hemostasis?

    <p>To limit blood flow and decrease hemorrhage</p> Signup and view all the answers

    Which phase involves the activation and aggregation of platelets resulting in the formation of a temporary Primary Hemostatic Plug?

    <p>Platelet Plug Phase</p> Signup and view all the answers

    What is the end product of the Blood Coagulation Phase in the hemostatic mechanism?

    <p>Fibrin mesh</p> Signup and view all the answers

    What is the role of activated factor XIII in the hemostatic mechanism?

    <p>To polymerize fibrin</p> Signup and view all the answers

    Which factor prevents clot extension by stabilizing the platelet aggregates in a Fibrin Clot?

    <p>Activated factor XIII</p> Signup and view all the answers

    What is the first step in the amplification phase of coagulation?

    <p>Adherence of platelets to exposed von Willebrand Factor</p> Signup and view all the answers

    Which complex is formed by the intrinsic Tenase Complex and activates the formation of the Prothrombinase Complex?

    <p>IXa + VIIIa</p> Signup and view all the answers

    What is the role of thrombin during the propagation phase of coagulation?

    <p>Stimulates fibrinogen transformation into fibrin</p> Signup and view all the answers

    Which factor is activated by thrombin during the initiation phase and subsequently stimulates factor X activation?

    <p>Factor V</p> Signup and view all the answers

    What is the key function of the extrinsic Tenase complex in preventing clot extension?

    <p>Activating factor IX to IXa</p> Signup and view all the answers

    What phase of the coagulation process follows the Initiation Phase?

    <p>Amplification Phase</p> Signup and view all the answers

    Which cells play a role in activating coagulation factors during the Amplification and Propagation Phases?

    <p>Endothelial cells</p> Signup and view all the answers

    What type of cascade model is coagulation now viewed as?

    <p>Cell-biological model</p> Signup and view all the answers

    Which factor activates Factor X to Factor Xa during the Initiation Phase of coagulation?

    <p>Factor VIIa</p> Signup and view all the answers

    What initiates the Amplification Phase of Coagulation?

    <p>Thrombin spark binding to PAR receptors</p> Signup and view all the answers

    Which phase involves the full activation of platelets during the coagulation process?

    <p>'Platelet Plug' Phase</p> Signup and view all the answers

    What is responsible for activating Factor IX to Factor IXa during the Initiation Phase?

    <p>'Tissue Factor'</p> Signup and view all the answers

    Which phase of coagulation involves the activation of Factor II (Prothrombin) to Thrombin (IIa)?

    <p>'Initiation' Phase</p> Signup and view all the answers

    What type of pathway continues to activate IX and X during the initiation phase?

    <p>Extrinsic Pathway</p> Signup and view all the answers

    Which aspect of coagulation does the little thrombin present during initiation ignite?

    <p>Platelet activation</p> Signup and view all the answers

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