Podcast
Questions and Answers
What is the role of thrombin burst in the coagulation cascade?
What is the role of thrombin burst in the coagulation cascade?
- Increasing formation of plasmin and activating protein C
- Inhibiting factors IIa, Xa, and other coagulation factors
- Promoting vasodilation and inhibiting platelet activation
- Activating XIII for cross-linking fibrin into polymers (correct)
Which natural anticoagulant inhibits factors IIa, Xa, and other coagulation factors?
Which natural anticoagulant inhibits factors IIa, Xa, and other coagulation factors?
- Antithrombin III (correct)
- Protein S
- Protein C
- Heparin
What prevents clot extension once formed by inhibiting the extrinsic Tenase complex?
What prevents clot extension once formed by inhibiting the extrinsic Tenase complex?
- Prostacyclin
- Heparin
- Nitric oxide
- Tissue-Factor Pathway Inhibitor (TFPI) (correct)
Which autocrine-paracrine mediator secretes nitric oxide to inhibit platelet adhesion and aggregation?
Which autocrine-paracrine mediator secretes nitric oxide to inhibit platelet adhesion and aggregation?
What is the function of protein S in the clotting process?
What is the function of protein S in the clotting process?
Which of the following is NOT a mechanism by which anticoagulant agents can block steps in coagulation?
Which of the following is NOT a mechanism by which anticoagulant agents can block steps in coagulation?
Which enzyme plays a key role in the process of fibrinolysis by causing the complete dissolution of the fibrin clot?
Which enzyme plays a key role in the process of fibrinolysis by causing the complete dissolution of the fibrin clot?
In the context of blood clot dissolution, what is the role of tissue plasminogen activator (t-PA)?
In the context of blood clot dissolution, what is the role of tissue plasminogen activator (t-PA)?
Which type of inhibitor blocks coagulation by directly binding to thrombin?
Which type of inhibitor blocks coagulation by directly binding to thrombin?
What is the function of factor X inhibitors in preventing clot extension?
What is the function of factor X inhibitors in preventing clot extension?
What is the main role of the clotting factors circulating in the blood vessels?
What is the main role of the clotting factors circulating in the blood vessels?
Why is the speed of blood flow important in preventing activation of clotting factors?
Why is the speed of blood flow important in preventing activation of clotting factors?
What is the function of endothelial cells in preventing clot formation?
What is the function of endothelial cells in preventing clot formation?
How does the glycoprotein coat on circulating platelets contribute to preventing clot formation?
How does the glycoprotein coat on circulating platelets contribute to preventing clot formation?
Which component of plasma contributes to preventing coagulation?
Which component of plasma contributes to preventing coagulation?
What is the purpose of the Fibrinolytic Phase in haemostasis?
What is the purpose of the Fibrinolytic Phase in haemostasis?
What regulates the Immediate Constriction Phase in haemostasis?
What regulates the Immediate Constriction Phase in haemostasis?
Which process converts soluble fibrinogen into an insoluble fibrin fiber during haemostasis?
Which process converts soluble fibrinogen into an insoluble fibrin fiber during haemostasis?
What do Coagulation Factors mainly belong to in the context of haemostasis?
What do Coagulation Factors mainly belong to in the context of haemostasis?
Which enzyme catalyzes the decarboxylation of Vit K-dependent Coagulation Factors in haemostasis?
Which enzyme catalyzes the decarboxylation of Vit K-dependent Coagulation Factors in haemostasis?
What is the main purpose of the Immediate Constriction Phase in hemostasis?
What is the main purpose of the Immediate Constriction Phase in hemostasis?
Which phase involves the activation and aggregation of platelets resulting in the formation of a temporary Primary Hemostatic Plug?
Which phase involves the activation and aggregation of platelets resulting in the formation of a temporary Primary Hemostatic Plug?
What is the end product of the Blood Coagulation Phase in the hemostatic mechanism?
What is the end product of the Blood Coagulation Phase in the hemostatic mechanism?
What is the role of activated factor XIII in the hemostatic mechanism?
What is the role of activated factor XIII in the hemostatic mechanism?
Which factor prevents clot extension by stabilizing the platelet aggregates in a Fibrin Clot?
Which factor prevents clot extension by stabilizing the platelet aggregates in a Fibrin Clot?
What is the first step in the amplification phase of coagulation?
What is the first step in the amplification phase of coagulation?
Which complex is formed by the intrinsic Tenase Complex and activates the formation of the Prothrombinase Complex?
Which complex is formed by the intrinsic Tenase Complex and activates the formation of the Prothrombinase Complex?
What is the role of thrombin during the propagation phase of coagulation?
What is the role of thrombin during the propagation phase of coagulation?
Which factor is activated by thrombin during the initiation phase and subsequently stimulates factor X activation?
Which factor is activated by thrombin during the initiation phase and subsequently stimulates factor X activation?
What is the key function of the extrinsic Tenase complex in preventing clot extension?
What is the key function of the extrinsic Tenase complex in preventing clot extension?
What phase of the coagulation process follows the Initiation Phase?
What phase of the coagulation process follows the Initiation Phase?
Which cells play a role in activating coagulation factors during the Amplification and Propagation Phases?
Which cells play a role in activating coagulation factors during the Amplification and Propagation Phases?
What type of cascade model is coagulation now viewed as?
What type of cascade model is coagulation now viewed as?
Which factor activates Factor X to Factor Xa during the Initiation Phase of coagulation?
Which factor activates Factor X to Factor Xa during the Initiation Phase of coagulation?
What initiates the Amplification Phase of Coagulation?
What initiates the Amplification Phase of Coagulation?
Which phase involves the full activation of platelets during the coagulation process?
Which phase involves the full activation of platelets during the coagulation process?
What is responsible for activating Factor IX to Factor IXa during the Initiation Phase?
What is responsible for activating Factor IX to Factor IXa during the Initiation Phase?
Which phase of coagulation involves the activation of Factor II (Prothrombin) to Thrombin (IIa)?
Which phase of coagulation involves the activation of Factor II (Prothrombin) to Thrombin (IIa)?
What type of pathway continues to activate IX and X during the initiation phase?
What type of pathway continues to activate IX and X during the initiation phase?
Which aspect of coagulation does the little thrombin present during initiation ignite?
Which aspect of coagulation does the little thrombin present during initiation ignite?
