Coagulation Cascade and Clot Formation Quiz

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What is the role of thrombin burst in the coagulation cascade?

Increasing formation of plasmin and activating protein C

Inhibiting factors IIa, Xa, and other coagulation factors

Promoting vasodilation and inhibiting platelet activation

Activating XIII for cross-linking fibrin into polymers (correct)

Which natural anticoagulant inhibits factors IIa, Xa, and other coagulation factors?

Antithrombin III (correct)

Protein S

Protein C

Heparin

What prevents clot extension once formed by inhibiting the extrinsic Tenase complex?

Prostacyclin

Heparin

Nitric oxide

Tissue-Factor Pathway Inhibitor (TFPI) (correct)

Which autocrine-paracrine mediator secretes nitric oxide to inhibit platelet adhesion and aggregation?

Prostacyclin Signup and view all the answers

What is the function of protein S in the clotting process?

Inhibiting factors V & VIII activity Signup and view all the answers

Which of the following is NOT a mechanism by which anticoagulant agents can block steps in coagulation?

Platelet activation by releasing tissue plasminogen activator Signup and view all the answers

Which enzyme plays a key role in the process of fibrinolysis by causing the complete dissolution of the fibrin clot?

Plasmin Signup and view all the answers

In the context of blood clot dissolution, what is the role of tissue plasminogen activator (t-PA)?

Conversion of plasminogen to plasmin Signup and view all the answers

Which type of inhibitor blocks coagulation by directly binding to thrombin?

Direct thrombin inhibitors Signup and view all the answers

What is the function of factor X inhibitors in preventing clot extension?

Interfere with factor X activation Signup and view all the answers

What is the main role of the clotting factors circulating in the blood vessels?

To remain inactive until an injury occurs Signup and view all the answers

Why is the speed of blood flow important in preventing activation of clotting factors?

To prevent clotting factors from coming in contact with TF Signup and view all the answers

What is the function of endothelial cells in preventing clot formation?

To secrete mediators with potential anticoagulant action Signup and view all the answers

How does the glycoprotein coat on circulating platelets contribute to preventing clot formation?

It provides repulsion forces preventing sticking to healthy endothelium Signup and view all the answers

Which component of plasma contributes to preventing coagulation?

Natural anticoagulants like anti-thrombin III and heparin Signup and view all the answers

What is the purpose of the Fibrinolytic Phase in haemostasis?

To prevent uncontrolled extension of thrombus or its embolization. Signup and view all the answers

What regulates the Immediate Constriction Phase in haemostasis?

Nervous reflex induced by existing pain of injury. Signup and view all the answers

Which process converts soluble fibrinogen into an insoluble fibrin fiber during haemostasis?

Blood Coagulation Phase. Signup and view all the answers

What do Coagulation Factors mainly belong to in the context of haemostasis?

Plasma proteins. Signup and view all the answers

Which enzyme catalyzes the decarboxylation of Vit K-dependent Coagulation Factors in haemostasis?

Vitamin K. Signup and view all the answers

What is the main purpose of the Immediate Constriction Phase in hemostasis?

To limit blood flow and decrease hemorrhage Signup and view all the answers

Which phase involves the activation and aggregation of platelets resulting in the formation of a temporary Primary Hemostatic Plug?

Platelet Plug Phase Signup and view all the answers

What is the end product of the Blood Coagulation Phase in the hemostatic mechanism?

Fibrin mesh Signup and view all the answers

What is the role of activated factor XIII in the hemostatic mechanism?

To polymerize fibrin Signup and view all the answers

Which factor prevents clot extension by stabilizing the platelet aggregates in a Fibrin Clot?

Activated factor XIII Signup and view all the answers

What is the first step in the amplification phase of coagulation?

Adherence of platelets to exposed von Willebrand Factor Signup and view all the answers

Which complex is formed by the intrinsic Tenase Complex and activates the formation of the Prothrombinase Complex?

IXa + VIIIa Signup and view all the answers

What is the role of thrombin during the propagation phase of coagulation?

Stimulates fibrinogen transformation into fibrin Signup and view all the answers

Which factor is activated by thrombin during the initiation phase and subsequently stimulates factor X activation?

Factor V Signup and view all the answers

What is the key function of the extrinsic Tenase complex in preventing clot extension?

Activating factor IX to IXa Signup and view all the answers

What phase of the coagulation process follows the Initiation Phase?

Amplification Phase Signup and view all the answers

Which cells play a role in activating coagulation factors during the Amplification and Propagation Phases?

Endothelial cells Signup and view all the answers

What type of cascade model is coagulation now viewed as?

Cell-biological model Signup and view all the answers

Which factor activates Factor X to Factor Xa during the Initiation Phase of coagulation?

Factor VIIa Signup and view all the answers

What initiates the Amplification Phase of Coagulation?

Thrombin spark binding to PAR receptors Signup and view all the answers

Which phase involves the full activation of platelets during the coagulation process?

'Platelet Plug' Phase Signup and view all the answers

What is responsible for activating Factor IX to Factor IXa during the Initiation Phase?

'Tissue Factor' Signup and view all the answers

Which phase of coagulation involves the activation of Factor II (Prothrombin) to Thrombin (IIa)?

'Initiation' Phase Signup and view all the answers

What type of pathway continues to activate IX and X during the initiation phase?

Extrinsic Pathway Signup and view all the answers

Which aspect of coagulation does the little thrombin present during initiation ignite?

Platelet activation Signup and view all the answers