CNS Pharmacology and Mental Health Quiz

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Questions and Answers

Which of the following is a structural change in the CNS associated with neurodegeneration?

  • Enhanced glutamate activity
  • Cortical atrophy (correct)
  • Increased dopamine levels
  • Decreased ventricle size

Which neurotransmitter theory is associated with the use of NMDA antagonists in the treatment of schizophrenia?

  • GABA theory
  • Dopamine theory
  • Serotonin theory
  • Glutamate theory (correct)

Which receptor profile is a difference between typical and atypical antipsychotics?

  • 5-HT receptor profile (correct)
  • D2 receptor profile
  • GABA receptor profile
  • D1 receptor profile

Which of the following is an adverse effect associated with D2 receptor antagonists?

<p>Increased prolactin secretion (B)</p> Signup and view all the answers

Which receptor do typical antipsychotics block?

<p>5-HT2 receptors (D)</p> Signup and view all the answers

How long does it typically take for D2 receptor antagonists to be effective?

<p>Days/weeks (A)</p> Signup and view all the answers

Which of the following is an extrapyramidal disturbance associated with D2 receptor antagonists?

<p>Increased aggression (B)</p> Signup and view all the answers

Which of the following is a behavioral effect associated with D2 receptor antagonists?

<p>Apathy (B)</p> Signup and view all the answers

Which of the following is an adverse effect associated with D2 receptor antagonists?

<p>Catalepsy (B)</p> Signup and view all the answers

Which of the following is an adverse effect associated with D2 receptor antagonists?

<p>Tardive dyskinesia (A)</p> Signup and view all the answers

Which receptor(s) does Amilsulpiride selectively block?

<p>D2 receptors (B)</p> Signup and view all the answers

Which receptor(s) does Respiridone selectively block?

<p>D2 and 5-HT2A receptors (D)</p> Signup and view all the answers

Which receptor(s) does Clozapine block?

<p>M and H receptors (C)</p> Signup and view all the answers

Which type of depression is characterized by oscillations between depression and mania?

<p>Bi-polar depression (A)</p> Signup and view all the answers

What is the main cause of reactive depression?

<p>Stress (D)</p> Signup and view all the answers

Which theory suggests that depression is caused by deficient monoaminergic transmission in the CNS?

<p>Monoamine theory of depression (B)</p> Signup and view all the answers

Which type of antidepressants block the uptake of both NA and 5-HT and also block α2 receptors?

<p>Tricyclic antidepressants (TCAs) (D)</p> Signup and view all the answers

Which neurotransmitter's increased levels elevate mood?

<p>Serotonin (C)</p> Signup and view all the answers

Which neurotransmitter's increased levels encourage motor activity?

<p>Noradrenaline (D)</p> Signup and view all the answers

Which class of antidepressants blocks 5-HT uptake more than NA uptake?

<p>Selective serotonin reuptake inhibitors (SSRIs) (B)</p> Signup and view all the answers

Dopamine releasers and agonists are part of the glutamate theory of schizophrenia.

<p>False (B)</p> Signup and view all the answers

Typical antipsychotics have a higher incidence of extrapyramidal effects compared to atypical antipsychotics.

<p>True (A)</p> Signup and view all the answers

D2 receptor antagonists take days/weeks to be effective.

<p>True (A)</p> Signup and view all the answers

Typical antipsychotics can be taken with alcohol without any adverse effects.

<p>False (B)</p> Signup and view all the answers

Apathy and reduced initiative are behavioral effects associated with D2 receptor antagonists.

<p>True (A)</p> Signup and view all the answers

Tardive dyskinesia is an extrapyramidal disturbance associated with D2 receptor antagonists.

<p>True (A)</p> Signup and view all the answers

Amilsulpiride selectively blocks α, H1, M, and 5-HT2 receptors.

<p>False (B)</p> Signup and view all the answers

Clozapine blocks D2 receptors.

<p>False (B)</p> Signup and view all the answers

Respiridone selectively blocks 5-HT receptors.

<p>False (B)</p> Signup and view all the answers

NMDA antagonists are associated with the glutamate theory of schizophrenia.

<p>True (A)</p> Signup and view all the answers

True or false: Amilsulpiride selectively blocks D2 receptors.

<p>True (A)</p> Signup and view all the answers

True or false: Clozapine blocks D2, 5-HT2A, M, and H receptors.

<p>True (A)</p> Signup and view all the answers

True or false: Imipramine and amitriptyline block uptake of NA and 5-HT.

<p>True (A)</p> Signup and view all the answers

True or false: Phenelzine and tranylcypromine bind both isoenzymes and inhibit their activity.

<p>True (A)</p> Signup and view all the answers

True or false: Selective serotonin reuptake inhibitors (SSRIs) block NA uptake more than 5-HT uptake.

<p>False (B)</p> Signup and view all the answers

True or false: SSRIs are as effective as tricyclic antidepressants (TCAs).

<p>True (A)</p> Signup and view all the answers

True or false: Withdrawal effects can occur when decreasing the dose of SSRIs.

<p>True (A)</p> Signup and view all the answers

True or false: Increased levels of serotonin in the CNS can cause mental state changes and hyperstimulation of serotonin receptors.

<p>True (A)</p> Signup and view all the answers

True or false: Non-compliance with antidepressant medication can be a cause of ineffectiveness.

<p>True (A)</p> Signup and view all the answers

True or false: Changing from one antidepressant medication to another usually requires a week free of antidepressants.

<p>True (A)</p> Signup and view all the answers

Which of the following is NOT a structural change in the CNS associated with ongoing neurodegeneration?

<p>Glutamate excitotoxicity (A)</p> Signup and view all the answers

Which neurotransmitter theory is associated with the use of NMDA antagonists in the treatment of schizophrenia?

<p>Glutamate theory (A)</p> Signup and view all the answers

Which of the following is an adverse effect associated with typical antipsychotics?

<p>Catalepsy (D)</p> Signup and view all the answers

Which receptor(s) do typical antipsychotics block?

<p>α, H1, M, 5-HT2 (B)</p> Signup and view all the answers

Which neurotransmitter's increased levels encourage motor activity?

<p>Dopamine (B)</p> Signup and view all the answers

Which of the following is an extrapyramidal disturbance associated with D2 receptor antagonists?

<p>Parkinsonian symptoms: rigidity, tremor, akinesia (B)</p> Signup and view all the answers

Which type of antidepressants block the uptake of both NA and 5-HT and also block α2 receptors?

<p>Tricyclic antidepressants (TCAs) (A)</p> Signup and view all the answers

Which neurotransmitter's increased levels elevate mood?

<p>Serotonin (C)</p> Signup and view all the answers

True or false: Clozapine blocks D2, 5-HT2A, M, and H receptors.

<p>True (A)</p> Signup and view all the answers

Which theory suggests that depression is caused by deficient monoaminergic transmission in the CNS?

<p>5-HT theory (A)</p> Signup and view all the answers

Which receptor(s) does Clozapine block?

<p>D2, 5-HT2A, M, and H receptors (A)</p> Signup and view all the answers

Which of the following is an adverse effect associated with typical antipsychotics?

<p>Dry mouth and blurred vision (A)</p> Signup and view all the answers

Which class of antidepressants blocks the uptake of both NA and 5-HT and also blocks α2 receptors?

<p>Tricyclic antidepressants (TCAs) (D)</p> Signup and view all the answers

Which neurotransmitter theory is associated with the use of NMDA antagonists in the treatment of schizophrenia?

<p>Glutamate theory (B)</p> Signup and view all the answers

Which of the following is a behavioral effect associated with D2 receptor antagonists?

<p>Increased motor activity (A)</p> Signup and view all the answers

Which type of depression is characterized by oscillations between depression and mania?

<p>Bi-polar depression (C)</p> Signup and view all the answers

Which receptor(s) does Amilsulpiride selectively block?

<p>D2 receptor (C)</p> Signup and view all the answers

Which receptor(s) does Respiridone selectively block?

<p>5-HT2A receptor (D)</p> Signup and view all the answers

Which class of antidepressants blocks 5-HT uptake more than NA uptake?

<p>Selective serotonin reuptake inhibitors (SSRIs) (A)</p> Signup and view all the answers

Which theory suggests that depression is caused by deficient monoaminergic transmission in the CNS?

<p>Monoamine theory (A)</p> Signup and view all the answers

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