CNS Pharmacology and Mental Health Quiz
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Questions and Answers

Which of the following is a structural change in the CNS associated with neurodegeneration?

  • Enhanced glutamate activity
  • Cortical atrophy (correct)
  • Increased dopamine levels
  • Decreased ventricle size

    • Which neurotransmitter theory is associated with the use of NMDA antagonists in the treatment of schizophrenia?

  • GABA theory
  • Dopamine theory
  • Serotonin theory
  • Glutamate theory (correct)

    • Which receptor profile is a difference between typical and atypical antipsychotics?

  • 5-HT receptor profile (correct)
  • D2 receptor profile
  • GABA receptor profile
  • D1 receptor profile

    • Which of the following is an adverse effect associated with D2 receptor antagonists?

    <p>Increased prolactin secretion</p> Signup and view all the answers

    Which receptor do typical antipsychotics block?

    <p>5-HT2 receptors</p> Signup and view all the answers

    How long does it typically take for D2 receptor antagonists to be effective?

    <p>Days/weeks</p> Signup and view all the answers

    Which of the following is an extrapyramidal disturbance associated with D2 receptor antagonists?

    <p>Increased aggression</p> Signup and view all the answers

    Which of the following is a behavioral effect associated with D2 receptor antagonists?

    <p>Apathy</p> Signup and view all the answers

    Which of the following is an adverse effect associated with D2 receptor antagonists?

    <p>Catalepsy</p> Signup and view all the answers

    Which of the following is an adverse effect associated with D2 receptor antagonists?

    <p>Tardive dyskinesia</p> Signup and view all the answers

    Which receptor(s) does Amilsulpiride selectively block?

    <p>D2 receptors</p> Signup and view all the answers

    Which receptor(s) does Respiridone selectively block?

    <p>D2 and 5-HT2A receptors</p> Signup and view all the answers

    Which receptor(s) does Clozapine block?

    <p>M and H receptors</p> Signup and view all the answers

    Which type of depression is characterized by oscillations between depression and mania?

    <p>Bi-polar depression</p> Signup and view all the answers

    What is the main cause of reactive depression?

    <p>Stress</p> Signup and view all the answers

    Which theory suggests that depression is caused by deficient monoaminergic transmission in the CNS?

    <p>Monoamine theory of depression</p> Signup and view all the answers

    Which type of antidepressants block the uptake of both NA and 5-HT and also block α2 receptors?

    <p>Tricyclic antidepressants (TCAs)</p> Signup and view all the answers

    Which neurotransmitter's increased levels elevate mood?

    <p>Serotonin</p> Signup and view all the answers

    Which neurotransmitter's increased levels encourage motor activity?

    <p>Noradrenaline</p> Signup and view all the answers

    Which class of antidepressants blocks 5-HT uptake more than NA uptake?

    <p>Selective serotonin reuptake inhibitors (SSRIs)</p> Signup and view all the answers

    Dopamine releasers and agonists are part of the glutamate theory of schizophrenia.

    <p>False</p> Signup and view all the answers

    Typical antipsychotics have a higher incidence of extrapyramidal effects compared to atypical antipsychotics.

    <p>True</p> Signup and view all the answers

    D2 receptor antagonists take days/weeks to be effective.

    <p>True</p> Signup and view all the answers

    Typical antipsychotics can be taken with alcohol without any adverse effects.

    <p>False</p> Signup and view all the answers

    Apathy and reduced initiative are behavioral effects associated with D2 receptor antagonists.

    <p>True</p> Signup and view all the answers

    Tardive dyskinesia is an extrapyramidal disturbance associated with D2 receptor antagonists.

    <p>True</p> Signup and view all the answers

    Amilsulpiride selectively blocks α, H1, M, and 5-HT2 receptors.

    <p>False</p> Signup and view all the answers

    Clozapine blocks D2 receptors.

    <p>False</p> Signup and view all the answers

    Respiridone selectively blocks 5-HT receptors.

    <p>False</p> Signup and view all the answers

    NMDA antagonists are associated with the glutamate theory of schizophrenia.

    <p>True</p> Signup and view all the answers

    True or false: Amilsulpiride selectively blocks D2 receptors.

    <p>True</p> Signup and view all the answers

    True or false: Clozapine blocks D2, 5-HT2A, M, and H receptors.

    <p>True</p> Signup and view all the answers

    True or false: Imipramine and amitriptyline block uptake of NA and 5-HT.

    <p>True</p> Signup and view all the answers

    True or false: Phenelzine and tranylcypromine bind both isoenzymes and inhibit their activity.

    <p>True</p> Signup and view all the answers

    True or false: Selective serotonin reuptake inhibitors (SSRIs) block NA uptake more than 5-HT uptake.

    <p>False</p> Signup and view all the answers

    True or false: SSRIs are as effective as tricyclic antidepressants (TCAs).

    <p>True</p> Signup and view all the answers

    True or false: Withdrawal effects can occur when decreasing the dose of SSRIs.

    <p>True</p> Signup and view all the answers

    True or false: Increased levels of serotonin in the CNS can cause mental state changes and hyperstimulation of serotonin receptors.

    <p>True</p> Signup and view all the answers

    True or false: Non-compliance with antidepressant medication can be a cause of ineffectiveness.

    <p>True</p> Signup and view all the answers

    True or false: Changing from one antidepressant medication to another usually requires a week free of antidepressants.

    <p>True</p> Signup and view all the answers

    Which of the following is NOT a structural change in the CNS associated with ongoing neurodegeneration?

    <p>Glutamate excitotoxicity</p> Signup and view all the answers

    Which neurotransmitter theory is associated with the use of NMDA antagonists in the treatment of schizophrenia?

    <p>Glutamate theory</p> Signup and view all the answers

    Which of the following is an adverse effect associated with typical antipsychotics?

    <p>Catalepsy</p> Signup and view all the answers

    Which receptor(s) do typical antipsychotics block?

    <p>α, H1, M, 5-HT2</p> Signup and view all the answers

    Which neurotransmitter's increased levels encourage motor activity?

    <p>Dopamine</p> Signup and view all the answers

    Which of the following is an extrapyramidal disturbance associated with D2 receptor antagonists?

    <p>Parkinsonian symptoms: rigidity, tremor, akinesia</p> Signup and view all the answers

    Which type of antidepressants block the uptake of both NA and 5-HT and also block α2 receptors?

    <p>Tricyclic antidepressants (TCAs)</p> Signup and view all the answers

    Which neurotransmitter's increased levels elevate mood?

    <p>Serotonin</p> Signup and view all the answers

    True or false: Clozapine blocks D2, 5-HT2A, M, and H receptors.

    <p>True</p> Signup and view all the answers

    Which theory suggests that depression is caused by deficient monoaminergic transmission in the CNS?

    <p>5-HT theory</p> Signup and view all the answers

    Which receptor(s) does Clozapine block?

    <p>D2, 5-HT2A, M, and H receptors</p> Signup and view all the answers

    Which of the following is an adverse effect associated with typical antipsychotics?

    <p>Dry mouth and blurred vision</p> Signup and view all the answers

    Which class of antidepressants blocks the uptake of both NA and 5-HT and also blocks α2 receptors?

    <p>Tricyclic antidepressants (TCAs)</p> Signup and view all the answers

    Which neurotransmitter theory is associated with the use of NMDA antagonists in the treatment of schizophrenia?

    <p>Glutamate theory</p> Signup and view all the answers

    Which of the following is a behavioral effect associated with D2 receptor antagonists?

    <p>Increased motor activity</p> Signup and view all the answers

    Which type of depression is characterized by oscillations between depression and mania?

    <p>Bi-polar depression</p> Signup and view all the answers

    Which receptor(s) does Amilsulpiride selectively block?

    <p>D2 receptor</p> Signup and view all the answers

    Which receptor(s) does Respiridone selectively block?

    <p>5-HT2A receptor</p> Signup and view all the answers

    Which class of antidepressants blocks 5-HT uptake more than NA uptake?

    <p>Selective serotonin reuptake inhibitors (SSRIs)</p> Signup and view all the answers

    Which theory suggests that depression is caused by deficient monoaminergic transmission in the CNS?

    <p>Monoamine theory</p> Signup and view all the answers

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