CM Comprehensive Exam Study Notes
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Questions and Answers

What department is the CSF tube labeled 3 routinely sent to?

  • Hematology (correct)
  • Chemistry
  • Microbiology
  • Serology
  • Which of the following findings is consistent with a subarachnoid hemorrhage rather than a traumatic tap?

  • A clear supernatant after centrifugation
  • Clearing of the fluid as it is aspirated
  • Xanthochromia (correct)
  • Presence of a protein in the sample
  • Which condition is most often associated with normal CSF glucose and protein?

  • Subarachnoid hemorrhage
  • Multiple sclerosis
  • Viral meningitis (correct)
  • Malignancy
  • A web-like pellicle in a refrigerated CSF specimen indicates:

    <p>Tubercular meningitis</p> Signup and view all the answers

    Which observation is least useful in distinguishing a hemorrhagic serous fluid from a traumatic tap?

    <p>The formation of a clot</p> Signup and view all the answers

    The finding of oligoclonal bands in the CSF and not in the serum is seen with:

    <p>Multiple sclerosis</p> Signup and view all the answers

    CSF lactate will be more consistently decreased in:

    <p>Viral meningitis</p> Signup and view all the answers

    Elevated CSF protein values can be caused by all of the following except:

    <p>Fluid leakage</p> Signup and view all the answers

    What is the most common cause of male infertility?

    <p>Varicocele</p> Signup and view all the answers

    Which morphological abnormality of sperm is most often associated with varicocele?

    <p>Tapering of the head</p> Signup and view all the answers

    What is the upper limit of normal for white blood cells (WBCs) in seminal fluid analysis?

    <p>1 × 10^6/mL</p> Signup and view all the answers

    Which carbohydrate measurement is clinically useful when performing a seminal fluid analysis?

    <p>Fructose</p> Signup and view all the answers

    What should be done if the specimen for semen analysis is delayed more than 2 hours?

    <p>Should be frozen</p> Signup and view all the answers

    Post-vasectomy semen analysis should be conducted how many months after the surgery?

    <p>2 Months</p> Signup and view all the answers

    What does a red or brown discoloration in semen indicate?

    <p>Blood</p> Signup and view all the answers

    How should specimens for FLM testing be transported and stored in the laboratory?

    <p>Delivered on ice and refrigerated</p> Signup and view all the answers

    Which test best correlates with the severity of hemolytic disease of the fetus and newborn (HDFN)?

    <p>Amniotic fluid bilirubin</p> Signup and view all the answers

    Which method is considered the reference for determining fetal lung maturity (FLM)?

    <p>Lecithin/sphingomyelin (L/S) ratio</p> Signup and view all the answers

    What accurately describes human chorionic gonadotropin (hCG) levels in pregnancy?

    <p>In ectopic pregnancy, serum hCG doubling time is below expected levels</p> Signup and view all the answers

    Which statement about alpha fetoprotein (AFP) levels is correct?

    <p>Maternal serum may be used to screen for open neural tube defects</p> Signup and view all the answers

    Which amniotic fluid color indicates hemolytic disease of the newborn?

    <p>Yellow - Hemolytic disease of the newborn (bilirubin)</p> Signup and view all the answers

    What is the purpose of detecting creatinine levels in amniotic fluid?

    <p>Detect maternal urine</p> Signup and view all the answers

    At what gestational age is it recommended to determine early treatment or intervention for Down syndrome?

    <p>15 to 18 weeks</p> Signup and view all the answers

    What specimen collection method is used for screening neural tube defects?

    <p>Amniocentesis</p> Signup and view all the answers

    What reagent is used in the mucin clot test?

    <p>Acetic acid</p> Signup and view all the answers

    Which crystal is most commonly associated with gout?

    <p>Uric acid or monosodium urate</p> Signup and view all the answers

    What type of arthritis is characterized by a synovial WBC count greater than 50,000/µL?

    <p>Septic arthritis</p> Signup and view all the answers

    Which cells in the stomach secrete hydrochloric acid (HCl) and intrinsic factor?

    <p>Parietal cells</p> Signup and view all the answers

    What is the highest level of serum gastrin usually found in?

    <p>Zollinger-Ellison (Z-E) syndrome</p> Signup and view all the answers

    What type of gastric tube is inserted through the nose?

    <p>Levine tube</p> Signup and view all the answers

    Which type of crystal causes pseudogout?

    <p>Calcium pyrophosphate dihydrate</p> Signup and view all the answers

    What type of fluid is collected by thoracentesis?

    <p>Pleural fluid</p> Signup and view all the answers

    How many days will hCG in urine disappear after ectopic pregnancy?

    <p>3-7 days</p> Signup and view all the answers

    Which animal source is used for anti-hCG in home-based pregnancy test kits?

    <p>Rabbit</p> Signup and view all the answers

    What change in urine is an indicator of pre-eclampsia?

    <p>Albuminuria</p> Signup and view all the answers

    What reagent is used in the Apt test?

    <p>Sodium hydroxide</p> Signup and view all the answers

    Which factor will NOT interfere with the reagent strip test for leukocytes?

    <p>Nitrite</p> Signup and view all the answers

    Which of the following statements about sputum is true?

    <p>Produced by the tracheobronchial tree</p> Signup and view all the answers

    What is the renal threshold for glucose?

    <p>160-180 mg/dL</p> Signup and view all the answers

    What is the renal threshold for potassium?

    <p>Potassium has no threshold</p> Signup and view all the answers

    What is the most likely etiology of urethritis in a patient with dysuria, urgency, and urethral discharge?

    <p>Neisseria gonorrhoeae</p> Signup and view all the answers

    Which condition is associated with urinalysis results in a patient with lupus erythematosus?

    <p>Chronic glomerulonephritis</p> Signup and view all the answers

    What is the identity of the object pointed by the arrow in the microscopy image?

    <p>Cholesterol crystal</p> Signup and view all the answers

    Which microscopy technique is depicted in the provided image?

    <p>Interference contrast</p> Signup and view all the answers

    Identify the types of cells shown in the microscopy image.

    <p>Transitional epithelial cells</p> Signup and view all the answers

    What type of fecal occult blood test (FOBT) kit is shown in the image?

    <p>Guaiac-based</p> Signup and view all the answers

    Which cell type is indicated in the microscopy image?

    <p>Sertoli cell</p> Signup and view all the answers

    The crystal observed in the image below is soluble in which of the following substances?

    <p>A and B</p> Signup and view all the answers

    Study Notes

    CM Comprehensive Exam Study Notes

    • CSF Labelling and Department: CSF tubes labeled 3 are routinely sent to Microbiology.

    • Subarachnoid Hemorrhage vs. Traumatic Tap: A clear supernatant after centrifugation, and the presence of xanthochromia are more indicative of a traumatic tap than a subarachnoid hemorrhage, which is associated with clearing of fluid. Protein in the sample is not a useful differentiator.

    • Conditions with Normal CSF Glucose and Protein: Viral meningitis is most often associated with normal CSF glucose and protein levels.

    • Pellicle in Refrigerated CSF: A web-like pellicle in refrigerated CSF suggests tubercular meningitis.

    • CSF Cell Count: A total CSF cell count on a clear fluid should be reported as normal in the absence of additional factors or symptoms.

    • Hemorrhagic Serous Fluid vs. Traumatic Tap: The formation of a clot in the CSF, rather than clearing, suggests a hemorrhagic serous fluid as opposed to a traumatic tap. A diminished RBC count in successive aliquots is also less useful to distinguish these.

    • Oligoclonal Bands: The presence of oligoclonal bands in CSF but not in serum is associated with multiple sclerosis.

    • CSF Lactate: Viral meningitis is more consistently associated with lower CSF lactate levels compared to other causes like bacterial meningitis.

    • Neurosyphilis Test: The test of choice for detecting neurosyphilis is the VDRL test.

    • Elevated CSF Protein: Elevated CSF protein values are seen in conditions like meningitis, multiple sclerosis, and fluid leakage, but not always in CNS malignancy.

    • CSF Differentiation: CSF can be differentiated from serum by the presence of globulin.

    • Spermatozoa Maturation: Spermatozoa maturation occurs in the seminiferous tubules.

    • Semen Enzymes: Enzymes for semen coagulation and liquefaction originate from the seminal vesicles.

    • Temperature for CSF: The freezing temperature is a factor routinely sent to the CSF tubes labelled 3.

    • Time for Semen Liquefaction: Liquefaction of a semen specimen should take place within 1 hour.

    • -glucosidase Measurement: This enzymatic measurement aids in detecting disorders related to the seminiferous tubules, epididymis.

    • Motility Rating: Rapid, straight-line motility is recorded as 4.0

    • Common Cause of Male Infertility: Varicocele is the most common cause of male infertility.

    • Sperm Concentration: The lower limit of normal sperm concentration is 15 million per milliliter.

    • Sperm Morphological Abnormality: Tapering of the sperm head is the most frequent morphological abnormality associated with varicocele.

    • Semen Analysis Results: Abnormal results (volume, liquefaction, pH, motility) suggest analysis variation and should be verified.

    • Seminal Fluid Analysis WBCs: The upper limit of normal for WBCs in seminal fluid analysis is 1 x 106/mL.

    • Carbohydrate Measurement in Semen Analysis: Fructose level is clinically useful when performing a seminal fluid analysis.

    • Reagent Strips: When using reagent strips, maintain the strips at room temperature, and store in dark airtight containers; blot on tissue following use and do not expose strips to moisture.

    • Other Tests: The information discusses several other clinical tests, conditions, and factors relative to a comprehensive exam.

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    Description

    Prepare for your comprehensive exam with these detailed notes on cerebrospinal fluid (CSF) analysis and related conditions. This review covers important distinctions between subarachnoid hemorrhage and traumatic tap, normal CSF glucose and protein levels, as well as indications of various meningitis types. Ideal for medical students and exam candidates.

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