Clinical Use of a Human Monoclonal Antibody
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Questions and Answers

What is the main route of administration for most drugs?

  • Topical
  • Subcutaneous
  • Oral (correct)
  • Intravenous
  • Which part of the GI tract is considered the most important endocrine system?

  • Small intestine (correct)
  • Esophagus
  • Stomach
  • Colon
  • What is an example of a drug that can have direct effects on the GI system?

  • Antihistamines
  • Antibiotics
  • NSAIDs (correct)
  • Beta blockers
  • What type of study might be conducted when there is a suspicion of a specific adverse reaction to a drug?

    <p>Cohort study</p> Signup and view all the answers

    Which system can potentially interact with drugs in the GI tract?

    <p>Endocrine system</p> Signup and view all the answers

    What is the function of gastric mucus in the GI tract?

    <p>Protects the stomach lining from acid damage</p> Signup and view all the answers

    What is the clinical use of a human monoclonal antibody S.c. in patients with moderate-to-severe ulcerative colitis?

    <p>Induction and maintenance of remission in steroid-refractory or steroid-dependent UC</p> Signup and view all the answers

    Which adverse effect is associated with the suppression of the TH1 inflammatory response by the human monoclonal antibody S.c.?

    <p>Reactivation of latent tuberculosis</p> Signup and view all the answers

    What type of adverse infusion reaction is commonly seen with the administration of the human monoclonal antibody S.c.?

    <p>Fever, chills, pruritus, urticaria, or cardiopulmonary symptoms</p> Signup and view all the answers

    What infection is a potential risk due to the use of the human monoclonal antibody S.c.?

    <p>Pneumonia</p> Signup and view all the answers

    Which autoimmune response can develop as an adverse effect of the human monoclonal antibody S.c. treatment?

    <p>Antibodies against murine epitope of infliximab</p> Signup and view all the answers

    What type of infection is commonly associated with the reactivation of latent tuberculosis in patients receiving the human monoclonal antibody S.c.?

    <p>Pneumocystosis</p> Signup and view all the answers

    What adverse effect can be seen in long-term use of proton pump inhibitors (PPIs) related to calcium absorption?

    <p>Increased absorption of calcium leading to osteoporosis</p> Signup and view all the answers

    Which of the following is a potential gastrointestinal (GI) adverse effect associated with prolonged inhibition of gastric secretion?

    <p>Decreased absorption of iron and vitamin B12</p> Signup and view all the answers

    What is a possible neurological adverse effect associated with the use of proton pump inhibitors?

    <p>Lightheadedness and headaches</p> Signup and view all the answers

    Which condition might be exacerbated in elderly or postmenopausal women due to prolonged use of proton pump inhibitors?

    <p>Osteoporosis</p> Signup and view all the answers

    What potential skin-related adverse effect can be associated with the use of proton pump inhibitors?

    <p>Rash and itching</p> Signup and view all the answers

    What interaction with other drugs can be expected when using proton pump inhibitors?

    <p>Reduced absorption for ampicillin and ketoconazole</p> Signup and view all the answers

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