Clinical Use of a Human Monoclonal Antibody
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Questions and Answers

What is the main route of administration for most drugs?

  • Topical
  • Subcutaneous
  • Oral (correct)
  • Intravenous

Which part of the GI tract is considered the most important endocrine system?

  • Small intestine (correct)
  • Esophagus
  • Stomach
  • Colon

What is an example of a drug that can have direct effects on the GI system?

  • Antihistamines
  • Antibiotics
  • NSAIDs (correct)
  • Beta blockers

What type of study might be conducted when there is a suspicion of a specific adverse reaction to a drug?

<p>Cohort study (D)</p> Signup and view all the answers

Which system can potentially interact with drugs in the GI tract?

<p>Endocrine system (D)</p> Signup and view all the answers

What is the function of gastric mucus in the GI tract?

<p>Protects the stomach lining from acid damage (A)</p> Signup and view all the answers

What is the clinical use of a human monoclonal antibody S.c. in patients with moderate-to-severe ulcerative colitis?

<p>Induction and maintenance of remission in steroid-refractory or steroid-dependent UC (C)</p> Signup and view all the answers

Which adverse effect is associated with the suppression of the TH1 inflammatory response by the human monoclonal antibody S.c.?

<p>Reactivation of latent tuberculosis (A)</p> Signup and view all the answers

What type of adverse infusion reaction is commonly seen with the administration of the human monoclonal antibody S.c.?

<p>Fever, chills, pruritus, urticaria, or cardiopulmonary symptoms (B)</p> Signup and view all the answers

What infection is a potential risk due to the use of the human monoclonal antibody S.c.?

<p>Pneumonia (B)</p> Signup and view all the answers

Which autoimmune response can develop as an adverse effect of the human monoclonal antibody S.c. treatment?

<p>Antibodies against murine epitope of infliximab (A)</p> Signup and view all the answers

What type of infection is commonly associated with the reactivation of latent tuberculosis in patients receiving the human monoclonal antibody S.c.?

<p>Pneumocystosis (C)</p> Signup and view all the answers

What adverse effect can be seen in long-term use of proton pump inhibitors (PPIs) related to calcium absorption?

<p>Increased absorption of calcium leading to osteoporosis (C)</p> Signup and view all the answers

Which of the following is a potential gastrointestinal (GI) adverse effect associated with prolonged inhibition of gastric secretion?

<p>Decreased absorption of iron and vitamin B12 (D)</p> Signup and view all the answers

What is a possible neurological adverse effect associated with the use of proton pump inhibitors?

<p>Lightheadedness and headaches (A)</p> Signup and view all the answers

Which condition might be exacerbated in elderly or postmenopausal women due to prolonged use of proton pump inhibitors?

<p>Osteoporosis (B)</p> Signup and view all the answers

What potential skin-related adverse effect can be associated with the use of proton pump inhibitors?

<p>Rash and itching (A)</p> Signup and view all the answers

What interaction with other drugs can be expected when using proton pump inhibitors?

<p>Reduced absorption for ampicillin and ketoconazole (D)</p> Signup and view all the answers

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