18 Questions
What is the main route of administration for most drugs?
Oral
Which part of the GI tract is considered the most important endocrine system?
Small intestine
What is an example of a drug that can have direct effects on the GI system?
NSAIDs
What type of study might be conducted when there is a suspicion of a specific adverse reaction to a drug?
Cohort study
Which system can potentially interact with drugs in the GI tract?
Endocrine system
What is the function of gastric mucus in the GI tract?
Protects the stomach lining from acid damage
What is the clinical use of a human monoclonal antibody S.c. in patients with moderate-to-severe ulcerative colitis?
Induction and maintenance of remission in steroid-refractory or steroid-dependent UC
Which adverse effect is associated with the suppression of the TH1 inflammatory response by the human monoclonal antibody S.c.?
Reactivation of latent tuberculosis
What type of adverse infusion reaction is commonly seen with the administration of the human monoclonal antibody S.c.?
Fever, chills, pruritus, urticaria, or cardiopulmonary symptoms
What infection is a potential risk due to the use of the human monoclonal antibody S.c.?
Pneumonia
Which autoimmune response can develop as an adverse effect of the human monoclonal antibody S.c. treatment?
Antibodies against murine epitope of infliximab
What type of infection is commonly associated with the reactivation of latent tuberculosis in patients receiving the human monoclonal antibody S.c.?
Pneumocystosis
What adverse effect can be seen in long-term use of proton pump inhibitors (PPIs) related to calcium absorption?
Increased absorption of calcium leading to osteoporosis
Which of the following is a potential gastrointestinal (GI) adverse effect associated with prolonged inhibition of gastric secretion?
Decreased absorption of iron and vitamin B12
What is a possible neurological adverse effect associated with the use of proton pump inhibitors?
Lightheadedness and headaches
Which condition might be exacerbated in elderly or postmenopausal women due to prolonged use of proton pump inhibitors?
Osteoporosis
What potential skin-related adverse effect can be associated with the use of proton pump inhibitors?
Rash and itching
What interaction with other drugs can be expected when using proton pump inhibitors?
Reduced absorption for ampicillin and ketoconazole
Explore the clinical applications of a human monoclonal antibody, including induction and maintenance of remission in ulcerative colitis and Crohn's disease, treatment of anal fistula, and management of rheumatic inflammatory diseases such as rheumatoid arthritis. Learn about potential adverse effects and precautions.
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