Monoclonal Antibody Quiz

Monoclonal antibodies are identical because they were produced by one type of immune cell, all are clones of a single parent cell. On the other hand, Polyclonal antibodies are secreted by different B cell lineages within the body. They are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different ______.

Monoclonal antibodies bind specifically to a particular antigen only at a particular ______.

Monoclonal antibodies are used in technologies like pregnancy tests for their ability to target specific antigens. In contrast, Polyclonal antibodies come from multiple B cell lineages and can identify different ______ on the same antigen.

One of the limitations of using Immunotherapeutics is the potential for immune ______ during pregnancy due to the body's rejection of foreign substances.

Monoclonal antibodies offer the advantage of precise targeting due to their specificity for a single epitope, while Polyclonal antibodies provide a broader immune response by targeting multiple ______ on the antigen.

Polyclonal antibodies may exhibit a more diverse response to an antigen due to their origin from different B cell lineages. This diversity allows for the recognition of various ______ on the same antigen.

Bi-specific monoclonal antibody is an artificial protein made from two different monoclonal antibodies that can bind to two different types of ___________ simultaneously.

In cancer immunotherapy, BsMAbs are engineered to bind to a cytotoxic cell using a receptor like ________ and a target like a tumour cell to be destroyed.

The Fc region of a bispecific monoclonal antibody is made up of the two _______ chains and forms the third binding site.

Trifunctional antibodies additionally bind to a cell that expresses Fc receptors, like a ________, a natural killer cell or a dendritic cell.

Polyclonal antibodies are produced by different __________, each producing a specific antibody.

During pregnancy, immune rejection can occur due to differences in _________ between the mother and the fetus.

Antibodies are classified based on the constant regions—Each class has the same constant regions. Immunological Response Of Antigen-antibody Bindings includes qComplement cascade, qPhagocytosis, qGenerate signals to mobilize cytokines and immunological responses, qAntibody dependent cell mediated cytotoxicity. If an antibody binds to native proteins, same reactions proceed resulting in ______ disorders.

Self-antigen binding antibodies may be created due to mutation and VDJ recombination defective ______ deletion mechanism.

Can cancer be curable with antibody mediated response?Advantages Of Using Monoclonal Antibodies include qAmiable to Engineering, qMore half life, qLess adverse reactions, qMore specific immunogenicity, qTargeted drug delivery with limited resistance, qCross Reactivity can easily be tested. Effects of post-translational modification As ______.

Problems Of Using Mouse Monoclonal Antibodies include qPoor immune elicitor due to non-native Fc portion, qAdverse Immunological reactions, qHuman antibody production due to non-native Fc. Chimeric And Humanized Antibody: The modular nature of antibody functions has made it possible to convert a mouse monoclonal antibody into one that has some human segments but still retains its original antigen-binding specificity. This hybrid molecule is called a ______ antibody. 70%/30%.

Pregnancy tests are commonly based on the detection of specific ______.

Limitations of using Immunotherapeutics include potential ______ rejection.