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Questions and Answers
What is the normal serum inorganic phosphate range for adults?
What is the normal serum inorganic phosphate range for adults?
What are the three primary conditions that lead to phosphate dysfunction?
What are the three primary conditions that lead to phosphate dysfunction?
What percentage of filtered phosphate is reabsorbed in the proximal tubules?
What percentage of filtered phosphate is reabsorbed in the proximal tubules?
How much of filtered phosphate is excreted in urine?
How much of filtered phosphate is excreted in urine?
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What is necessary to explain disturbances of calcium metabolism?
What is necessary to explain disturbances of calcium metabolism?
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Study Notes
Phosphate Homeostasis
- Normal range of serum inorganic phosphate: • Adults: 2.4-4.5 mg/dl (0.8-1.5 mmol/l) • Children: 4-7 mg/dl (1.29-2.25 mmol/L)
Regulation of Phosphate Balance
- The kidneys play a crucial role in maintaining phosphate balance
- 90% of filtered phosphate is reabsorbed: • 80% in the proximal tubules • 10% in the distal tubules
- Remaining 10% is excreted in urine
Clinical Significance
- Disorders of phosphate homeostasis occur in various clinical conditions
- Both hyper and hypophosphatemia can result from cellular shifts of phosphate
- Three primary factors contributing to phosphate dysfunction: • Dietary intake • GI status • Renal status
Calcium Metabolism
- Inorganic phosphate plasma level is necessary to understand disturbances of calcium metabolism
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Description
Learn about the normal range of serum inorganic phosphate in adults and children, and disorders that affect phosphate homeostasis. Understand how cellular shifts, dietary intake, GI, and renal status affect phosphate balance.
