Cleavage: Early Embryonic Development
25 Questions
2 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the role of epithin in embryonic development?

  • Epithin is involved in the differentiation of the trophoblast.
  • Epithin is essential for the compaction of the embryo at the 8-cell stage. (correct)
  • Epithin is necessary for the development of the inner cell mass.
  • Epithin is involved in the formation of the placenta.
  • Which of the following genes is crucial for the maintenance of the inner cell mass?

  • Oct-4
  • Sox-2
  • Nanog (correct)
  • Cdx-2
  • Which of the following statements is TRUE about E-cadherin?

  • E-cadherin is essential for compaction, and blocking it prevents compaction. (correct)
  • E-cadherin is exclusively found in gap junctions.
  • E-cadherin is a calcium-independent cell adhesion molecule.
  • E-cadherin is only expressed in the outer cell mass of the blastocyst.
  • What is the relationship between the trophoblast and the embryo?

    <p>The trophoblast forms the fetal placental contribution. (A)</p> Signup and view all the answers

    Which of the following is NOT involved in the formation of the placenta?

    <p>Epiblast (C)</p> Signup and view all the answers

    What is the significance of 'compaction' during embryonic development?

    <p>Compaction is essential for the establishment of a clear distinction between the inner and outer cell masses. (B)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of dizygotic twins?

    <p>They share the same genetic material. (D)</p> Signup and view all the answers

    What is the primary purpose of the zona pellucida (ZP) following fertilization?

    <p>To prevent additional sperm from reaching the zygote (C)</p> Signup and view all the answers

    What is the significance of the 'decidual reaction' in the context of implantation?

    <p>It provides a protective barrier for the embryo from the maternal immune system. (D)</p> Signup and view all the answers

    What is the primary functional difference between the trophoblast and the inner cell mass (ICM)?

    <p>The trophoblast forms the placenta and contributes to implantation, while the ICM forms the embryo. (B)</p> Signup and view all the answers

    Which of the following is a characteristic shared by Nanog, Oct-4, Sox-2, and Cdx-2?

    <p>They are all transcription factors involved in regulating gene expression. (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of parapagus conjoined twins?

    <p>They have a complete separation of the head and torso. (B)</p> Signup and view all the answers

    What is the key event that marks the transition from maternal gene products to zygote-produced gene products during early development?

    <p>The 8-cell stage of cleavage (B)</p> Signup and view all the answers

    What is the primary role of the syncytiotrophoblast during implantation?

    <p>To invade uterine tissue and establish contact with maternal blood vessels (C)</p> Signup and view all the answers

    What is the main reason why the zona pellucida (ZP) serves as an immunological barrier between the mother and the embryo?

    <p>The ZP lacks the histocompatibility antigens usually found in the mother. (B)</p> Signup and view all the answers

    What is the primary cause of ectopic pregnancies?

    <p>Implantation in an abnormal site outside the uterus (C)</p> Signup and view all the answers

    Which of the following is NOT a common location for tubal pregnancies?

    <p>Ovarian follicle (C)</p> Signup and view all the answers

    Which of the following statements accurately describes the process of decidual reaction?

    <p>The uterine tissue responds to the embryo's invasion by forming a protective barrier. (C)</p> Signup and view all the answers

    Which of the following is NOT a factor that can contribute to infertility due to a failed hatching of the blastocyst?

    <p>A lack of specific hormones in the uterine lining (A)</p> Signup and view all the answers

    What distinguishes mammalian cleavage from that of lower vertebrates?

    <p>Mammalian cleavage utilizes a strategy that is more dependent on external nutrient sources from the mother. (D)</p> Signup and view all the answers

    What is the primary function of the trophoblastic tissues during mammalian embryonic development?

    <p>To eventually develop into the placenta, enabling nutrient exchange with the mother. (C)</p> Signup and view all the answers

    What is the significance of the blastomeres being totipotent up to the 8-cell stage?

    <p>It allows for the development of identical twins when the blastomeres separate into two distinct embryos. (B)</p> Signup and view all the answers

    How does the blastocoele form during mammalian embryonic development?

    <p>It is formed by the accumulation of fluid secreted between inner blastomeres, driven by sodium transport. (B)</p> Signup and view all the answers

    What is the role of cadherin in mammalian embryonic development?

    <p>Cadherin plays a key role in cell-cell adhesion, holding cells together during development. (C)</p> Signup and view all the answers

    Which of the following statements accurately describes the relationship between cleavage and the development of the blastocyst?

    <p>Cleavage precedes the formation of the blastocyst, with the blastocyst arising from the resulting blastomeres. (C)</p> Signup and view all the answers

    Flashcards

    Cleavage

    The rapid cell divisions of the zygote that begin ~24 hours after fertilization.

    Totipotent Cell

    A cell that can develop into a complete organism.

    Morula

    A solid ball of cells formed after several rounds of cleavage.

    Blastocyst

    A hollow ball of cells formed after zygote cleavage.

    Signup and view all the flashcards

    Blastomere

    The resulting daughter cells from the division of the zygote.

    Signup and view all the flashcards

    Blastocoel

    A fluid-filled cavity within the blastocyst.

    Signup and view all the flashcards

    Cavitation

    The formation of the blastocoel due to fluid secretions among inner blastomeres.

    Signup and view all the flashcards

    Cadherin

    A calcium-dependent cell adhesion protein essential for cell-cell connections.

    Signup and view all the flashcards

    Epithin

    A mammalian serine protease associated with E-cadherin at the embryo's 8-cell stage.

    Signup and view all the flashcards

    Inner Cell Mass

    The cluster of cells in the blastocyst that will become the embryo.

    Signup and view all the flashcards

    Trophoblast

    The outer cell mass of the blastocyst that forms the interface with the mother and contributes to the placenta.

    Signup and view all the flashcards

    Compaction

    The process at the 8-cell stage where blastomeres adhere tightly, forming a 16-cell morula.

    Signup and view all the flashcards

    Oct-4

    A gene necessary for maintaining pluripotency in early embryonic development.

    Signup and view all the flashcards

    FGF-4

    A signaling molecule vital for blastocyst development and implantation into the uterine wall.

    Signup and view all the flashcards

    Monozygotic Twinning

    Twins that originate from one fertilized egg, sharing the same genetic material.

    Signup and view all the flashcards

    Decidual Reaction

    The transformation of endometrial stromal cells into decidual cells to support the embryo post-implantation.

    Signup and view all the flashcards

    Parapagus

    A form of conjoined twins with side-by-side connection, sharing a pelvis.

    Signup and view all the flashcards

    Heteropagus

    Asymmetrical twin formation where one twin dominates nutrient supply from the placenta.

    Signup and view all the flashcards

    Blastocyte formation

    Occurs after compaction; cell numbers continue to increase leading to a blastocyst.

    Signup and view all the flashcards

    Zona Pellucida functions

    Protective layer that promotes oocyte maturation, prevents polyspermy, and acts as a filter.

    Signup and view all the flashcards

    Syncytiotrophoblast

    Multinucleated layer formed by fusion of cytotrophoblast cells during implantation.

    Signup and view all the flashcards

    Epiblast and Hypoblast

    Two layers formed from the inner cell mass, creating the bilaminar disk during development.

    Signup and view all the flashcards

    Ectopic pregnancy

    Implantation occurring outside the normal uterine location, often in the fallopian tubes.

    Signup and view all the flashcards

    Implantation timing

    The process starts 6-7 days post-fertilization as the blastocyst attaches to the uterine wall.

    Signup and view all the flashcards

    Human embryos hatch

    Embryos break through the zona pellucida just before implantation using secreted proteases.

    Signup and view all the flashcards

    Study Notes

    Cleavage: Early Embryonic Development

    • Cleavage is the first major event after fertilization, occurring approximately 24 hours post-fertilization.
    • Mammalian cleavage differs from lower vertebrates due to the placental connection. The lack of yolk storage in mammalian eggs necessitates a reliance on maternal nutrients.
    • Mammalian eggs are small, allowing for rapid cell divisions that convert the one-celled zygote to a multicellular embryo.
    • Cell divisions during cleavage are not perfectly synchronous, resulting in embryos with an odd number of cells.
    • Each cell division takes about 12-24 hours.
    • No growth occurs during cleavage; the embryo remains at roughly 0.1 mm in diameter.
    • The rapid increase in cell number occurs exponentially, following a pattern where the total cell number increases faster than the size.

    Cleavage Events

    • Cleavage involves rapid mitotic divisions without growth phases.
    • Blastomeres (the resulting daughter cells) progressively decrease in size with each division.
    • Blastomeres at the 8-cell stage are totipotent, meaning they can develop into a complete organism, crucial for twinning.
    • The process culminates in the formation of a morula, a solid ball of cells.
    • Subsequently, the morula forms a blastocyst, a hollow ball of cells.

    Blastocyst Formation and Cavitation

    • Cavitation is the formation of a fluid-filled cavity within the blastocyst known as the blastocoele.
    • This process is driven by sodium (Na+) transport mediated by sodium-potassium pumps (Na+/K+).
    • Sodium and water accumulate between inner blastomeres, creating the blastocoele.
    • Cavitation leads to the differentiation of the blastocyst into an inner cell mass (embryoblast) and an outer cell mass (trophoblast).

    Compaction and Cell Adhesion

    • Compaction occurs at the 8-cell stage, where blastomeres adhere more tightly together.
    • This results in a compact morula structure.
    • E-cadherin, a calcium-dependent cell adhesion protein, plays a crucial role in mediating compaction.
    • E-cadherin is essential for cell adhesion during compaction. Silencing of the epithin gene prevents compaction.

    Blastocyst Differentiation

    • The inner cell mass (ICM), also known as the embryoblast, will develop into the embryo proper.
    • The outer cell mass, also known as the trophoblast, forms the fetal placental contribution. The trophoblast is crucial for embryonic interactions with the mother and providing protection and delivering nutrients.

    Molecular Regulation of Cleavage

    • Key genes and proteins regulate early embryonic development.
    • Nanog, Oct-4, Sox-2, and Cdx-2 are critical regulators.
    • Nanog maintains the integrity of the inner cell mass (ICM).
    • Oct-4 (OCT-4) is associated with the pluripotency of cells.
    • Sox-2 regulates gene expression in the ICM post-8 cell stage.
    • Cdx-2 is essential for trophoblast differentiation.
    • LIF (Leukemia Inhibitory Factor) is also important for implantation and early embryonic development.

    Implantation

    • Implantation begins approximately 6-7 days after fertilization.
    • The uterus is prepared by hormones to receive the embryo.
    • The blastocyst adheres, penetrates, and becomes embedded in the uterine endometrium (the uterine lining).
    • The decidual reaction is a significant part of implantation, involving the transformation of endometrial stromal cells into decidual cells, supporting the implanting embryo.

    Twinning

    • Dizygotic twins originate from two eggs and two sperm.
    • Monozygotic twins originate from a single fertilized egg that splits into two embryos.
    • Splitting occurs earlier, around the 8-cell stage.
    • Conjoined twins (parapagus, ischiopagus, etc.) represent incomplete splitting.

    Zona Pellucida and Hatching

    • The zona pellucida plays a critical role in early embryonic development, preventing premature implantation.It restricts entry of sperm and acts as a protective filter.
    • The blastocyst hatches from the zona pellucida before implantation occurs.

    Ectopic Pregnancy

    • Ectopic pregnancies occur when implantation occurs outside the uterus.
    • Tubal ectopic pregnancies, where the blastocyst implants in a fallopian tube, are the most common type.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Explore the fascinating process of cleavage in early embryonic development, occurring after fertilization in mammals. This quiz delves into the differences between mammalian and lower vertebrate cleavage, highlighting the rapid cell divisions and unique characteristics of mammalian embryos. Test your knowledge of these critical early stages of life.

    More Like This

    Human Embryonic Development: Cleavage and Morula
    10 questions
    Deuterostome Development and Cleavage
    42 questions
    Embryonic Development: Cleavage and Mitosis
    24 questions
    Mammalian Embryonic Development Quiz
    24 questions
    Use Quizgecko on...
    Browser
    Browser