14 Questions
What is the primary goal of therapy in treating Clostridium difficile infection (CDI)?
To prevent CDI associated mortality
Which treatment option for CDI involves inhibiting nucleic acid synthesis by disrupting the DNA of microbial cells?
Metronidazole
What is a dose-and duration-dependent adverse effect of Metronidazole?
Peripheral neuropathy
An appropriate treatment principle for CDI management includes:
Initiating monitoring with a stool chart
What is the first-line treatment for mild to moderate Clostridioides difficile infection (CDI)?
Vancomycin
Which of the following is a common adverse effect associated with metronidazole therapy for CDI?
Neurotoxicity
What is the primary goal of therapy for Clostridioides difficile infection (CDI)?
Prevent recurrence and restore normal flora
In severe, complicated Clostridioides difficile infection (CDI), what is the recommended treatment regimen?
Combination therapy with vancomycin and metronidazole
Which of the following is a characteristic of severe, complicated Clostridium difficile infection (CDI)?
Presence of hypotension, shock, ileus, toxic megacolon, or perforation
What is the most appropriate initial treatment for mild-to-moderate CDI?
Oral vancomycin
What is a notable adverse effect associated with metronidazole use in CDI treatment?
Peripheral neuropathy
Which patient characteristic is associated with an increased risk of CDI recurrence?
Immunocompromised status
What is a key goal of Clostridium difficile infection (CDI) therapy?
Preventing CDI recurrence
In the context of CDI treatment principles, what should be considered when selecting antibiotics?
Considering the severity of infection and patient factors
Study Notes
Clostridium difficile Infection (CDI) Therapy
- The primary goal of therapy for CDI is to eradicate the infection and prevent recurrence.
Treatment Options
- Inhibiting nucleic acid synthesis by disrupting the DNA of microbial cells is a treatment option that involves the use of Metronidazole.
Adverse Effects of Metronidazole
- A dose-and-duration-dependent adverse effect of Metronidazole is neuropathy.
- A common adverse effect associated with metronidazole therapy for CDI is nausea and vomiting.
Treatment Principles
- An appropriate treatment principle for CDI management includes minimizing the use of antibiotics to reduce the risk of recurrence.
First-Line Treatment
- The first-line treatment for mild to moderate CDI is oral Vancomycin.
Severe, Complicated CDI
- In severe, complicated CDI, the recommended treatment regimen is oral Vancomycin in combination with intravenous Metronidazole.
- A characteristic of severe, complicated CDI is the presence of shock, ileus, or megacolon.
Mild-to-Moderate CDI
- The most appropriate initial treatment for mild-to-moderate CDI is oral Vancomycin.
Metronidazole Use
- A notable adverse effect associated with metronidazole use in CDI treatment is peripheral neuropathy.
Risk Factors for CDI Recurrence
- Older adults are more likely to experience CDI recurrence.
Key Goal of CDI Therapy
- A key goal of CDI therapy is to restore the normal gut flora.
Antibiotic Selection
- When selecting antibiotics for CDI treatment, the severity of the infection, the patient's medical history, and the risk of recurrence should be considered.
Assess the severity of Clostridium difficile infection (CDI) based on goals of therapy which include preventing mortality, morbidity, alleviating symptoms, curing the infection, minimizing adverse effects and recurrence, reducing costs, and preventing transmission. Understand the treatment options and goals for managing CDI.
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