Cirrhosis Complications Overview

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Questions and Answers

What is the normal total serum bilirubin level range?

  • 0.8-1.3 mg/dl
  • 0.3-1.2 mg/dl (correct)
  • 1.0-2.0 mg/dl
  • 0.5-1.5 mg/dl

What is an early sign of Wilson's disease?

  • Acute hepatitis
  • Decreased ceruloplasmin levels (correct)
  • Parkinsonism
  • Hepatosplenomegaly

What causes Dubin-Johnson syndrome?

  • Blockage of bile flow
  • Viral hepatitis
  • Deficiency in MRP2 (correct)
  • Excessive copper accumulation

What is the primary function of ATP7B in the liver?

<p>Exocytose copper into bile canaliculi (C)</p> Signup and view all the answers

Which condition can lead to dark urine and dark liver?

<p>Obstructive jaundice (A)</p> Signup and view all the answers

What is a common cause of increase in both unconjugated and conjugated bilirubin in the blood?

<p>Viral Hepatitis (C)</p> Signup and view all the answers

Which tissue does free copper primarily accumulate in Wilson's disease?

<p>Liver (B)</p> Signup and view all the answers

What complications can arise from obstructive jaundice?

<p>Pruritis, Steatorrhea (A)</p> Signup and view all the answers

Which symptom is NOT associated with hepatic encephalopathy?

<p>Jaundice (B)</p> Signup and view all the answers

What can trigger renal vasoconstriction leading to hepatorenal failure in cirrhosis?

<p>High portal vein pressure (D)</p> Signup and view all the answers

How does phototherapy help in treating physiologic jaundice of newborns?

<p>Converting bilirubin to a more soluble form (D)</p> Signup and view all the answers

What is the consequence of low liver function in hepatic encephalopathy?

<p>Accumulation of toxins in the brain (C)</p> Signup and view all the answers

In cirrhosis, what happens to estrogen metabolism with liver damage?

<p>Estrogen production increases (C)</p> Signup and view all the answers

What causes the yellow discoloration of skin and eyes in jaundice?

<p>Retention of bilirubin (B)</p> Signup and view all the answers

In compensated cirrhosis, what is the characteristic of the liver?

<p>Presence of small amount of scarring and fibrosis (C)</p> Signup and view all the answers

What is a common symptom of decompensated cirrhosis?

<p>All listed complications and symptoms (B)</p> Signup and view all the answers

How does hepatorenal failure progress from changes in portal flow?

<p>Renal vasoconstriction triggered (B)</p> Signup and view all the answers

'Asterixis', characterized by tremoring or jerky hands when outstretched, is a symptom of which complication?

<p>Hepatic encephalopathy (C)</p> Signup and view all the answers

'Palmar erythema', a condition seen in cirrhosis, is a result of what physiological process?

<p>'CB' secretion by hepatocytes (A)</p> Signup and view all the answers

What is the main cause of liver cirrhosis as discussed in the text?

<p>Excessive alcohol consumption (B)</p> Signup and view all the answers

What are considered the most common risk factors for liver cirrhosis based on the text?

<p>Excessive alcohol consumption and fatty liver (NASH) (A)</p> Signup and view all the answers

What does the presence of regenerative nodules, fibrotic tissue, and collagen indicate in liver pathology?

<p>Formation of scar tissue in the liver (D)</p> Signup and view all the answers

How does liver cirrhosis contribute to the development of jaundice?

<p>By impairing bilirubin excretion (A)</p> Signup and view all the answers

What role do hepatic stellate cells (HSC) play in the pathogenesis of liver fibrosis?

<p>Secreting paracrine factors that stimulate HSC proliferation (C)</p> Signup and view all the answers

In liver cirrhosis, how does the accumulation of fibrotic tissue affect blood flow in the liver?

<p>Compresses central veins and sinusoids (A)</p> Signup and view all the answers

Which factor contributes to activating hepatic stellate cells (HSC) in injured liver tissues?

<p>Paracrine factors from sinusoidal endothelial cells and hepatocytes (D)</p> Signup and view all the answers

What distinguishes liver cirrhosis from end-stage liver disease?

<p>Irreversible fibrosis and scarring (D)</p> Signup and view all the answers

What happens to hepatic stellate cells (HSC) when they are activated?

<p>They lose vitamin A and secrete TGF-β1 (A)</p> Signup and view all the answers

How does chronic inflammation in liver cirrhosis contribute to scar tissue formation?

<p>By enhancing natural wound healing processes (A)</p> Signup and view all the answers

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