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Chronic Obstructive Pulmonary Disease (COPD) Definitions

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Chronic Obstructive Pulmonary Disease (COPD) Definitions

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Questions and Answers

Which of the following is NOT a common genetic risk factor for COPD?

Genetic mutations leading to α-1 antitrypsin deficiency

Genetic mutations affecting serine proteases

Genetic mutations affecting inflammatory responses

Genetic mutations leading to hereditary deficiency of elastin (correct)

What is a major circulating inhibitor of serine proteases implicated in COPD?

Neutrophils

Elastin

α-1 antitrypsin (correct)

Macrophages

Which of the following is a characteristic feature of protease-mediated destruction in COPD?

Decreased neutrophils

Peribronchiolar fibrosis (correct)

Increased lymphocytes

Reduced macrophages

What structural changes occur in the lungs in COPD due to an imbalance between proteases and antiproteases?

Emphysema Signup and view all the answers

Which of the following is NOT a common pathophysiological feature of COPD?

Decreased mucus hypersecretion Signup and view all the answers

What is the main characteristic that distinguishes Chronic Bronchitis from Emphysema in COPD?

Presence of cough and sputum production Signup and view all the answers

What defines the duration criteria for Chronic Bronchitis as part of COPD diagnosis?

At least 3 months in each of two consecutive years Signup and view all the answers

Which statement accurately describes the role of cigarette smoking in the development of COPD?

Cigarette smoking is a key environmental risk factor for COPD. Signup and view all the answers

How are abnormalities of the airways and alveoli in COPD manifested?

Resulting in persistent, often progressive airflow obstruction Signup and view all the answers

What defines Emphysema pathologically in the context of COPD?

Permanent enlargement of airspaces with wall destruction Signup and view all the answers