Chronic Myelogenous Leukemia (CML) and DNA Polymerase Quiz
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Questions and Answers

Which cell type is most likely the origin of the initiating mutation in a CML patient?

  • A neutrophil
  • A lymphocyte
  • A macrophage
  • A hematopoietic stem cell (correct)
  • What is the role of DNA polymerase pol-δ?

  • Is involved in DNA synthesis
  • Is involved in proofreading newly synthesized DNA
  • Exhibits exonuclease activity
  • All of the above (correct)
  • What is often exhibited by benign skin lesions known as keratoses?

  • Mutant p53 alleles
  • A, B, and C (correct)
  • Mutations resulting from exposure to UV light
  • Mutations carrying a dipyrimidine substitution
  • What is the chemical structure formed from the reaction of a DNA base with a carcinogen called?

    <p>An adduct</p> Signup and view all the answers

    Loss of function of which gene is associated with an increased risk for breast and ovarian cancers?

    <p>Tumor suppressor gene</p> Signup and view all the answers

    How do mutations affecting the spindle assembly checkpoint contribute to cancer risk?

    <p>Aneuploidy</p> Signup and view all the answers

    Which process may result in the loss of function of a tumor suppressor gene?

    <p>A, B, and C</p> Signup and view all the answers

    Which type of cells are most protected from genomic damage?

    <p>Stem cells</p> Signup and view all the answers

    What is the direct consequence of impaired function of the spindle assembly checkpoint during mitosis?

    <p>Increased risk for ovarian cancer</p> Signup and view all the answers

    Defects in which of the following cellular processes may contribute to an increased incidence of cancer?

    <p>A, B, and C</p> Signup and view all the answers

    Which of the following may result in point mutations that can contribute to cancer?

    <p>All of the above</p> Signup and view all the answers

    Keratoses, or benign skin lesions, often exhibit:

    <p>A, B, and C</p> Signup and view all the answers

    What is the DNA polymerase pol-δ primarily involved in?

    <p>DNA synthesis</p> Signup and view all the answers

    Which cellular process is defective in cells that may contribute to an increased incidence of cancer?

    <p>A, B, and C</p> Signup and view all the answers

    What is a potential consequence of impaired function of the spindle assembly checkpoint during mitosis?

    <p>Aneuploidy</p> Signup and view all the answers

    How may loss of function of a tumor suppressor gene occur?

    <p>Hypermethylation of the gene's promoter</p> Signup and view all the answers

    Which type of cells are most protected from genomic damage?

    <p>Stem cells</p> Signup and view all the answers

    What is an associated risk when germ-line mutations occur in a gene?

    <p>Increased risk for breast and ovarian cancers</p> Signup and view all the answers

    How do mutations affecting DNA repair genes primarily manifest?

    <p>Increased risk for ovarian cancer</p> Signup and view all the answers

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