Podcast
Questions and Answers
Which cell type is most likely the origin of the initiating mutation in a CML patient?
Which cell type is most likely the origin of the initiating mutation in a CML patient?
- A neutrophil
- A lymphocyte
- A macrophage
- A hematopoietic stem cell (correct)
What is the role of DNA polymerase pol-δ?
What is the role of DNA polymerase pol-δ?
- Is involved in DNA synthesis
- Is involved in proofreading newly synthesized DNA
- Exhibits exonuclease activity
- All of the above (correct)
What is often exhibited by benign skin lesions known as keratoses?
What is often exhibited by benign skin lesions known as keratoses?
- Mutant p53 alleles
- A, B, and C (correct)
- Mutations resulting from exposure to UV light
- Mutations carrying a dipyrimidine substitution
What is the chemical structure formed from the reaction of a DNA base with a carcinogen called?
What is the chemical structure formed from the reaction of a DNA base with a carcinogen called?
Loss of function of which gene is associated with an increased risk for breast and ovarian cancers?
Loss of function of which gene is associated with an increased risk for breast and ovarian cancers?
How do mutations affecting the spindle assembly checkpoint contribute to cancer risk?
How do mutations affecting the spindle assembly checkpoint contribute to cancer risk?
Which process may result in the loss of function of a tumor suppressor gene?
Which process may result in the loss of function of a tumor suppressor gene?
Which type of cells are most protected from genomic damage?
Which type of cells are most protected from genomic damage?
What is the direct consequence of impaired function of the spindle assembly checkpoint during mitosis?
What is the direct consequence of impaired function of the spindle assembly checkpoint during mitosis?
Defects in which of the following cellular processes may contribute to an increased incidence of cancer?
Defects in which of the following cellular processes may contribute to an increased incidence of cancer?
Which of the following may result in point mutations that can contribute to cancer?
Which of the following may result in point mutations that can contribute to cancer?
Keratoses, or benign skin lesions, often exhibit:
Keratoses, or benign skin lesions, often exhibit:
What is the DNA polymerase pol-δ primarily involved in?
What is the DNA polymerase pol-δ primarily involved in?
Which cellular process is defective in cells that may contribute to an increased incidence of cancer?
Which cellular process is defective in cells that may contribute to an increased incidence of cancer?
What is a potential consequence of impaired function of the spindle assembly checkpoint during mitosis?
What is a potential consequence of impaired function of the spindle assembly checkpoint during mitosis?
How may loss of function of a tumor suppressor gene occur?
How may loss of function of a tumor suppressor gene occur?
Which type of cells are most protected from genomic damage?
Which type of cells are most protected from genomic damage?
What is an associated risk when germ-line mutations occur in a gene?
What is an associated risk when germ-line mutations occur in a gene?
How do mutations affecting DNA repair genes primarily manifest?
How do mutations affecting DNA repair genes primarily manifest?
