19 Questions
Which cell type is most likely the origin of the initiating mutation in a CML patient?
A hematopoietic stem cell
What is the role of DNA polymerase pol-δ?
All of the above
What is often exhibited by benign skin lesions known as keratoses?
A, B, and C
What is the chemical structure formed from the reaction of a DNA base with a carcinogen called?
An adduct
Loss of function of which gene is associated with an increased risk for breast and ovarian cancers?
Tumor suppressor gene
How do mutations affecting the spindle assembly checkpoint contribute to cancer risk?
Aneuploidy
Which process may result in the loss of function of a tumor suppressor gene?
A, B, and C
Which type of cells are most protected from genomic damage?
Stem cells
What is the direct consequence of impaired function of the spindle assembly checkpoint during mitosis?
Increased risk for ovarian cancer
Defects in which of the following cellular processes may contribute to an increased incidence of cancer?
A, B, and C
Which of the following may result in point mutations that can contribute to cancer?
All of the above
Keratoses, or benign skin lesions, often exhibit:
A, B, and C
What is the DNA polymerase pol-δ primarily involved in?
DNA synthesis
Which cellular process is defective in cells that may contribute to an increased incidence of cancer?
A, B, and C
What is a potential consequence of impaired function of the spindle assembly checkpoint during mitosis?
Aneuploidy
How may loss of function of a tumor suppressor gene occur?
Hypermethylation of the gene's promoter
Which type of cells are most protected from genomic damage?
Stem cells
What is an associated risk when germ-line mutations occur in a gene?
Increased risk for breast and ovarian cancers
How do mutations affecting DNA repair genes primarily manifest?
Increased risk for ovarian cancer
Test your knowledge on chronic myelogenous leukemia (CML) chromosomal translocations and DNA polymerase pol-δ. Determine the cell in which the initiating mutation occurred in CML and the functions of DNA polymerase pol-δ.
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