Chronic Kidney Diseases and Syndromes Overview
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What is Polyarteritis Nodosa?

A rare, non-infectious inflammatory disease that affects small and medium-sized arteries, causing them to become inflamed and weakened. This can lead to the formation of aneurysms (bulges in blood vessels) and can affect multiple organs, such as the skin, kidneys, heart, digestive system, and nervous system.

What is liquefaction degeneration?

The destruction of tissue due to infection or inflammation by white blood cells.

What is pleural effusion?

An accumulation of fluid in the pleural space (the space between the lungs and the chest wall). This can be caused by a variety of conditions, includ­ing infection, inflammation, heart failure, cancer and trauma.

What is bronchogenic carcinoma?

A type of tumor that originates from the epithelial cells that line the bronchi and bronchioles in the lungs. It is the most common type of lung cancer.

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What is chronic bronchitis?

A condition in which there is an overgrowth of the mucous glands in the large and small airways of the lungs, leading to an increased production of mucus and difficulty breathing.

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What are paraneoplastic syndromes?

A group of symptoms that occur in individuals with a variety of neoplasms that are not related to the primary tumor site but are triggered by the tumor. These symp­toms can be caused by tumor-secreted hormones, antibodies, or other substances.

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What is Sjögren's syndrome?

A disease characterized by inflammation of the salivary glands, which can lead to dry mouth and dry eyes. It can also affect other organs, such as the skin, nervous system, and joints.

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What is adenocarcinoma of the lung?

A type of lung cancer that arises from the epithelial cells that line the alveoli (the tiny air sacs in the lungs). This type of lung cancer is often found in people with a history of smoking.

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What is acromegaly?

A condition characterised by excessive growth of the pituitary gland, often lead­ing to the production of excess growth hormone. This can result in physical changes such as enlarged hands, feet and facial features, and a range of other health problems.

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What is pernicious anemia?

A type of anemia that is caused by a deficiency of vitamin B12. It can lead to a range of symptoms, including fatigue, weakness, tingling in the hands and feet, and neurological problems.

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What is Paget's disease of the bone?

A type of bone tumor characterized by excessive bone formation. It's often seen in older people and is usually benign, but it can sometimes become cancerous.

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What is hypoprothrombinemia?

A type of abnormal blood clotting that is caused by a deficiency of prothrombin, a protein needed for blood clotting. This can cause significant bleeding problems.

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What is Synovitis?

A type of arthritis that is characterized by inflammation of the synovium, the lining of the joints. It can cause pain, swelling, stiffness, and a limited range of motion in the affected joints.

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What is acute pancreatitis?

A type of inflammation of the pancreas that is characterized by the release of digestive enzymes into the pancreatic tissue, which can lead to a range of symptoms, such as severe abdominal pain, nausea, and vomiting.

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What is Myocarditis?

A type of heart disease that is characterized by the inflammation of the heart muscle, which can lead to a range of symptoms, including chest pain, shortness of breath, fatigue, and arrhythmia.

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What is cirrhosis?

A disease that affects the liver and is characterized by the buildup of scar tissue. This can lead to a range of symptoms, including jaundice, fatigue, swelling in the legs, and ascites.

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What is medullary carcinoma of the thyroid?

A type of tumor that occurs in the thyroid gland and secretes calcitonin, a hormone that helps regulate blood calcium levels. It's much less common than other thyroid cancers, but it is usually a slow growing cancer.

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What is osteoporosis?

A type of bone disease characterized by a decrease in bone density, making the bones more fragile and prone to fracture. It's common in older people and is especially common in women after menopause.

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What is hypertrophic cardiomyopathy?

A type of heart disease that is characterized by a thickening of the wall of the left ventricle, the main pumping chamber of the heart. This can make it hard for the heart to pump blood efficiently, leading to a range of symptoms, such as shortness of breath, chest pain, and fatigue.

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What is Conn's syndrome?

A type of disease characterized by the excessive release of the hormone aldosterone, which can lead to a range of symptoms, including high blood pressure, low potassium levels and increased sodium levels in the blood.

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What is renal cell carcinoma?

A type of tumor that affects the kidney and is often associated with the production of the hormone erythropoietin. It's usually a slow-growing tumor, but it can spread to other parts of the body if it's not treated early.

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What is papillary carcinoma of the thyroid?

A type of cancer that originates from the cells of the thyroid gland. It's the most common type of thyroid cancer, and it can be treated effectively if diagnosed early.

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What is osteopetrosis?

A type of rare bone disease characterized by an overgrowth of bone marrow in the long bones, which can lead to a range of symptoms, including pain, swelling, and deformities.

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What is a granulosa cell tumor?

A type of tumor that affects the ovaries and is often associated with the production of the hormone estrogen. It's a slow-growing tumor, but it can be treated effectively if diagnosed early.

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What is cystic fibrosis?

A rare genetic disorder that affects the pancreas and leads to the production of abnormally viscous mucus, which can block the ducts of the pancreas, and the airways of the lung. This can lead to a range of symptoms, including maldigestion, malnutrition, and respiratory problems.

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What is acute lymphocytic leukemia (ALL)?

A type of leukemia that is characterized by the presence of a large number of immature white blood cells in the bone marrow and blood. This type of leukemia is common in children and can be treated effectively with chemotherapy.

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What is Crohn's disease?

A disease that affects the small intestine and is characterized by the inflammation of the bowel wall. It can cause a range of symptoms, including diarrhea, abdominal pain, weight loss, and fatigue.

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What is coarctation of the aorta?

A type of heart disease that is characterized by a narrowing of the aorta, the main artery that carries blood from the heart to the body. This can cause a range of symptoms, including shortness of breath, chest pain, and fatigue.

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What is gastric carcinoma?

A type of cancer that affects the stomach and is often associated with the infection with Helicobacter pylori (H. pylori). It can lead to a range of symptoms, including abdominal pain, weight loss, and fatigue.

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What is iron deficiency anemia?

A type of anemia that is caused by a deficiency of iron. It can lead to a range of symptoms, including fatigue, weakness, shortness of breath, and pallor.

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What is cystitis?

A type of bacterial infection that affects the bladder. It's one of the most common types of infections, and it can be treated effectively with antibiotics.

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What is prostate carcinoma?

A type of tumor that affects the prostate gland, the gland that produces seminal fluid. It's usually a slow-growing tumor, but it can be treated effectively if diagnosed early.

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What is an adrenocortical adenoma?

A type of tumor that originates from the cells of the adrenal gland. This is one of the most common types of adrenal tumors, and it produces excess levels of hormones like cortisol, aldosterone, and androgens.

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What is a meningioma?

A type of tumor that affects the brain. It is a common brain tumor and can be either benign or malignant.

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What is bronchopulmonary sequestration?

A condition that affects the lungs and is characterized by the presence of small, fluid-filled sacs (alveoli). This can happen both before and after birth, and it can lead to a range of symptoms, including breathing difficulties, coughing, and wheezing.

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What is a pituitary adenoma?

A type of tumor that affects the brain and is often associated with the production of the hormone ACTH, which stimulates the production of cortisol by the adrenal gland. It's often slow-growing and can be treated effectively with surgery or radiation therapy.

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Study Notes

Membrano-Proliferative GN

  • Features NOT associated with Membrano-Proliferative GN: Hypercellular Glomeruli, Thickened Basement Membranes, Basement Membrane Spikes, Accentuated Lobular Pattern. Often presents as Nephrotic or Nephritic Syndrome.

Acute Diffuse Glomerulonephritis

  • Most frequent outcome: Progression to Chronic Renal Failure.
  • Other options: Progression to Acute Renal Failure, Complete recovery with conservative therapy, Progression to Focal Segmental Glomerulosclerosis.

Henoch-Schonlein Syndrome

  • Key feature: Crescent Formation.
  • Other features: Diffuse Thickening of Basement Membrane (not the definitive feature).

Acute Diffuse Tubular Necrosis

  • Conditions NOT associated: Transfusion with Hepatitis B infected blood.
  • Other conditions that ARE associated: Shock, Septicemia, Extensive Burns, Post-Partum Hemorrhage.

Surgically Treatable Hypertension

  • Cause: Fibromuscular Dysplasia of Renal Artery.
  • Other causes: Diabetes Mellitus, IgA Nephritis, SLE Nephritis, (not all are surgically treatable so this one is a key point)

Ampicillin Complications

  • Complication associated: Interstitial Nephritis.
  • Other options: Post Streptococcal Glomerulonephritis, IgA Nephropathy, Acute Tubular Necrosis.

Nephrotic Syndrome Causes

  • Excludes: Goodpasture Syndrome.
  • Includes: Diabetes Mellitus, SLE, (not all causes are listed).

Primary Biliary Cirrhosis

  • Features EXCEPT: Jaundice develops early in the course.
  • Other features: Common in Females, Present with Pruritis, Associated with Antimitochondrial Antibodies, Alkaline Phosphatase is Elevated.

Malignant Thyroid Tumor

  • Most frequent in young: Papillary Carcinoma.
  • Other options: Follicular, Medullary, Anaplastic, Lymphoma (not all tumors are listed in order by frequency).

Diabetic Microngiopathy

  • Excludes: Myocardial Infarction.
  • Other features: Retinopathy, Nephropathy, Neuropathy.

Hypocalcemia Causes

  • Excludes: Granulomatous Disease.
  • Other causes: Hypoparathyroidism, Renal Failure, Vitamin D Deficiency.

Lipiduria Causes

  • Causes: Nephrotic Syndrome.
  • Other options/causes: Ascending Pyelonephritis, Nephritic Syndrome, Obstructive Uropathy, Renal Infarction (not all listed in order of frequency.)

Right Renal Mass in 3-yr-old

  • Likely diagnosis: (NOT listed)

Hyperplastic Arteriosclerosis/Fibrinoid Necrosis

  • Associated with: Malignant Hypertension.
  • Other options: Diabetes Mellitus Type 2, Membranoproliferative Glomerulonephritis, Alport's Syndrome, Analgesic Abuse.

Membranous Glomerulonephritis

  • Features: Heavy proteinuria.

Rapidly Progressive Glomerulonephritis

  • Feature: Leukocyte Casts in Urine.
  • Other features: Crescent Formation, Insidious Onset (not all listed.)

Malignant Hypertension

  • Features: Hyperplastic Arteriosclerosis, Crescent Formation, Fibrinoid Necrosis, (not all listed as features.)

Diffuse Post Streptococcal Glomerulonephritis

  • Features NOT present: Fusion of Podocyte Food Processes.
  • Other features: Hypertension,Peri-Orbital Oedema, Granular Cast in Urine, Immune Complex Deposition, (not all listed.)

Low Serum Complement / Hypercellular Glomeruli / Subepithelial Immune Deposits

  • Conditions associated: Post Streptococcal GN
  • Other conditions: Alport's Syndrome, Minimal Change Disease, Interstitial Nephritis, IgA Nephropathy (not all listed)

Nodular Glomerulosclerosis

  • Associated with Diabetic Glomerular Change
  • Other causes: Malignant Hypertension (causes listed)

Basement Membrane Spikes

  • Condition: Idiopathic Membranous GN
  • Other condition: Membrano-Proliferative GN

C-ANCA Associated Glomerular Disease

  • Possible diagnosis: Type III RBGN

Primary Biliary Cirrhosis Associated Antibodies

  • Associated with: Antimitochondrial Antibodies
  • Other conditions: not explicitly stated.

Hepatocellular Carcinoma

  • Associated with: Hypoglycemia, Hyperglycemia, Gynecomastia, Raised Levels of HCG (not all listed)

Chronic Bronchitis

  • Smoking NOT a factor in: Smooth Muscle Hyperplasia.
  • Other factors: Squamous Metaplasia, Interference with Ciliary Action, Direct Damage to Airway Epithelium, Inhibits Bronchiolar & Alveolar Leukocytes (all smoking factors.)

Causes of Ischemic Tubular Necrosis

  • Excludes: Heterophagoctytosis
  • Includes: Azotemia, Oliguria, Hypokalemia, Metabolic Acidosis, Hypotension.

Nasopharyngeal Carcinoma

  • Excludes: Radical Surgery is standard treatment
  • Associated with infection by Epstein Barr Virus, Commonest Tumor in some parts of Africa, Metastasize the Cervical Lymph Node, Commonest Tumor in some parts of China

Chronic Endometritis

  • Features include, Menometorrhagia, Pelvic Inflammatory Disease (PID), Presence of Plasma Cells, Cytomegalovirus.

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Description

This quiz covers various types of glomerulonephritis, including Membrano-Proliferative Glomerulonephritis and Acute Diffuse Glomerulonephritis, as well as related conditions like Henoch-Schonlein Syndrome. It also addresses associated conditions in Acute Diffuse Tubular Necrosis and factors leading to surgically treatable hypertension. Test your knowledge on these important kidney conditions!

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