Chronic Kidney Disease: Diagnosis and Management
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A patient with chronic kidney disease (CKD) has a glomerular filtration rate (GFR) of $20 \text{ mL/min}/1.73 \text{m}^2$. According to the staging of CKD, how should this patient's kidney disease be classified?

  • Stage 4: Severe kidney damage
  • Stage 2: Mild kidney damage with slightly decreased GFR
  • End-Stage Renal Disease (ESRD) (correct)
  • Stage 3: Moderate kidney damage

Which of the following laboratory findings is LEAST likely to be associated with chronic kidney disease (CKD)?

  • Elevated serum creatinine
  • Decreased hemoglobin levels
  • Hypocholesterolemia (correct)
  • Hyperkalemia

Which of the following statements best describes the rationale for using ACE inhibitors or ARBs in patients with chronic kidney disease (CKD), particularly those with hypertension and proteinuria?

  • They promote sodium and water retention to improve kidney perfusion.
  • They help to reduce blood pressure and provide renal protection by reducing proteinuria. (correct)
  • They stimulate erythropoietin production to correct anemia.
  • They directly increase glomerular filtration rate (GFR).

A patient with chronic kidney disease (CKD) reports experiencing persistent itching (pruritus). Which of the following interventions is most appropriate for managing this symptom?

<p>Applying emollients to the skin (B)</p> Signup and view all the answers

A patient with chronic kidney disease (CKD) and a history of heart failure is prescribed sodium polystyrene sulfonate (Kayexalate) for hyperkalemia. What nursing assessment is most critical before administering this medication?

<p>Auscultating bowel sounds (C)</p> Signup and view all the answers

Which dietary modification is most important for a patient with chronic kidney disease (CKD) not yet on dialysis to help slow the progression of the disease?

<p>Restricted sodium and phosphorus intake (C)</p> Signup and view all the answers

A patient with chronic kidney disease (CKD) is prescribed epoetin alfa. What laboratory value should the nurse monitor to evaluate the effectiveness of this medication?

<p>Hemoglobin (D)</p> Signup and view all the answers

A patient with COPD is experiencing an exacerbation. Which of the following factors is least likely the cause of their current condition, assuming other typical triggers are present?

<p>Consistent adherence to a pulmonary rehabilitation program. (D)</p> Signup and view all the answers

During a physical assessment of a patient with suspected COPD, which finding would be least expected?

<p>Increased Forced Expiratory Volume in 1 second (FEV1). (A)</p> Signup and view all the answers

A patient newly diagnosed with COPD asks about the primary cause of the disease. Which of the following is the most accurate response?

<p>Smoking accounts for the majority of cases. (C)</p> Signup and view all the answers

Spirometry is performed on a patient suspected of having COPD. Which set of results would strongly indicate COPD?

<p>Decreased FEV1 and decreased FVC. (D)</p> Signup and view all the answers

Which of the following statements best describes the typical progression of COPD?

<p>Gradual worsening of symptoms over several years. (D)</p> Signup and view all the answers

Which of the following is NOT a typical trigger for a sickle cell crisis?

<p>Hyperoxemia (B)</p> Signup and view all the answers

A patient with sickle cell disease is experiencing a vaso-occlusive crisis. Which of the following signs and symptoms would be most likely to be observed?

<p>Cool, cyanotic extremities. (B)</p> Signup and view all the answers

Which type of sickle cell crisis involves the bone marrow temporarily ceasing red blood cell production?

<p>Aplastic crisis (A)</p> Signup and view all the answers

The swelling characteristic of sickle cell dactylitis is associated with what pathological process?

<p>Limited vascular necrosis of marrow. (C)</p> Signup and view all the answers

What is the primary goal of managing a patient experiencing a sickle cell crisis?

<p>Aggressively manage crisis-induced pain. (C)</p> Signup and view all the answers

Which of the following interventions is LEAST likely to minimize long-term organ dysfunction in a patient with sickle cell disease?

<p>Encouraging strenuous exercise during crises. (B)</p> Signup and view all the answers

Which of the following laboratory findings is NOT typically assessed in the diagnosis of Sickle Cell Disease?

<p>Erythrocyte Sedimentation Rate (ESR) (A)</p> Signup and view all the answers

Which of the following medications is LEAST likely to cause thrombocytopenia?

<p>Acetaminophen (B)</p> Signup and view all the answers

A patient with sickle cell anemia is prescribed Coumadin (warfarin) for an unrelated condition. What potential complication should the healthcare provider closely monitor for?

<p>Increased risk of bleeding due to impaired clotting. (D)</p> Signup and view all the answers

Which of the following is the MOST important aspect of parent education regarding children with sickle cell anemia?

<p>Understanding potential developmental delays and psychological challenges. (B)</p> Signup and view all the answers

A patient with iron deficiency anemia is prescribed oral iron supplements. Which instruction should the nurse include in the patient's education to enhance iron absorption?

<p>Consume iron supplements alongside a glass of orange juice. (A)</p> Signup and view all the answers

A patient presents with fatigue, pallor, and spoon-shaped nails (koilonychia). Which nutritional deficiency is MOST likely associated with these findings?

<p>Iron (D)</p> Signup and view all the answers

Which of the following neurological symptoms is MOST indicative of Vitamin B12 deficiency anemia rather than iron deficiency anemia?

<p>Paresthesia (numbness and tingling) (B)</p> Signup and view all the answers

A patient with a history of alcoholism is diagnosed with folic acid deficiency anemia. Which additional hematological abnormality would the nurse MOST likely observe in this patient?

<p>Pancytopenia (C)</p> Signup and view all the answers

A patient with folic acid deficiency is prescribed folic acid supplements. The patient is also taking phenytoin (Dilantin) for seizure control. What is the MOST important nursing consideration related to this drug interaction?

<p>Monitor for decreased phenytoin levels, potentially leading to seizures. (A)</p> Signup and view all the answers

During the management of a patient with anemia, the nurse is preparing to administer erythropoietin. Prior to administration, what laboratory value is MOST critical for the nurse to assess?

<p>Hemoglobin level (B)</p> Signup and view all the answers

A patient receiving erythropoietin for anemia develops hypertension. What is the underlying mechanism that MOST likely contributes to this adverse effect?

<p>Increased blood viscosity secondary to increased red blood cell production. (C)</p> Signup and view all the answers

A patient newly diagnosed with sickle cell disease asks the nurse about the genetic implications of the disease. What inheritance pattern should the nurse explain?

<p>Autosomal recessive (C)</p> Signup and view all the answers

A patient with sickle cell anemia is experiencing a vaso-occlusive crisis. Which intervention is the PRIORITY nursing action?

<p>Initiating oxygen therapy and administering pain medication. (A)</p> Signup and view all the answers

What is the underlying pathophysiology that leads to sickling of red blood cells in sickle cell disease?

<p>Abnormal hemoglobin S structure causing RBC deformation under hypoxemic conditions. (D)</p> Signup and view all the answers

A patient with BPH is considering watchful waiting. Which instruction is most important for the nurse to emphasize?

<p>Adhering to yearly digital rectal examinations (DREs). (A)</p> Signup and view all the answers

A patient diagnosed with BPH is prescribed an alpha-adrenergic blocker. The nurse knows that the therapeutic effect of this medication is achieved by which mechanism?

<p>Relaxing the smooth muscle of the prostate gland. (A)</p> Signup and view all the answers

A patient is scheduled for a TURP procedure. What potential postoperative complication should the nurse prioritize in their teaching?

<p>Urinary incontinence. (A)</p> Signup and view all the answers

Following a radical prostatectomy, a patient expresses concern about erectile dysfunction. Which response by the nurse is most appropriate?

<p>&quot;Nerve-sparing procedures are emerging, so it is possible to regain erectile function.&quot; (A)</p> Signup and view all the answers

A patient undergoing brachytherapy for prostate cancer asks the nurse about precautions they need to take at home. What information should the nurse include?

<p>They must abstain from sex for 2 weeks and use condoms thereafter. (A)</p> Signup and view all the answers

A 68-year-old man with a family history of prostate cancer is considering screening. Which statement would be most appropriate for the nurse to provide regarding prostate-specific antigen (PSA) testing?

<p>&quot;PSA testing can help detect prostate cancer early, but false positives and false negatives are possible.&quot; (A)</p> Signup and view all the answers

The nurse is caring for a patient who reports taking saw palmetto for BPH. Which assessment finding would warrant further investigation?

<p>The patient reports new onset of bleeding tendencies. (A)</p> Signup and view all the answers

A patient with prostate cancer is prescribed ablative hormone therapy. What is the primary goal of this treatment?

<p>To suppress testosterone production. (C)</p> Signup and view all the answers

Which dietary modification should a nurse recommend to a patient at risk of prostate cancer?

<p>Incorporate more fruits and vegetables into the diet. (C)</p> Signup and view all the answers

A patient with thrombocytopenia is being discharged home. Which instructions are most important to include in the discharge teaching plan? (Select all that apply)

<p>&quot;Monitor for signs of internal bleeding, such as black stools.&quot; (A), &quot;Use a soft-bristled toothbrush to avoid gum bleeding.&quot; (C), &quot;Use an electric razor instead of a traditional razor.&quot; (D), &quot;Avoid activities that could cause bruising or bleeding.&quot; (E)</p> Signup and view all the answers

A nurse is reviewing the laboratory results of a patient with anemia. Which of the following sets of results would MOST strongly suggest iron deficiency anemia?

<p>Decreased ferritin, decreased hemoglobin (D)</p> Signup and view all the answers

A patient with sickle cell crisis is admitted to the emergency department. Which intervention is the MOST important to implement?

<p>Providing intravenous fluids (D)</p> Signup and view all the answers

A patient is receiving a blood transfusion and begins to experience chills, fever, and lower back pain. What is the priority nursing action?

<p>Stopping the transfusion immediately and notify the healthcare provider (A)</p> Signup and view all the answers

A patient with COPD develops anemia. Which of the following underlying mechanisms is MOST likely contributing to the anemia in this patient?

<p>Anemia of chronic disease (A)</p> Signup and view all the answers

A patient presents with fatigue, pallor, and tachycardia. Lab results show Hgb of 6.7 g/dL, Hct of 23%, and low ferritin levels. Which of the following dietary recommendations should the nurse provide?

<p>Lean red meats (B), Spinach and kale (C), Legumes and beans (E)</p> Signup and view all the answers

A 72-year-old male with a history of BPH presents with increasing urinary hesitancy, weak urinary stream, and nocturia. What diagnostic test is the most appropriate for confirming BPH?

<p>Digital Rectal Exam (DRE) (D)</p> Signup and view all the answers

A patient with chronic kidney disease (CKD) is diagnosed with anemia of chronic disease. What is the most likely cause of anemia in this patient?

<p>Decreased production of erythropoietin (D)</p> Signup and view all the answers

Which of the following are risk factors for prostate cancer?

<p>Diet low in fruits and vegetables (C), Family history of prostate cancer (D), African American ethnicity (E)</p> Signup and view all the answers

Which patient is at highest risk for developing iron deficiency anemia?

<p>A 25-year-old pregnant woman (D)</p> Signup and view all the answers

A nurse is assessing a patient with suspected sickle cell crisis. Which of the following clinical manifestations are consistent with this diagnosis?

<p>Decreased hemoglobin levels (A), Pallor and jaundice (B), Splenomegaly (C), Severe joint and bone pain (E)</p> Signup and view all the answers

Which of the following are priority interventions for a patient admitted in sickle cell crisis?

<p>Provide oxygen therapy (A), Administer opioids as prescribed (B), Administer IV fluids (E)</p> Signup and view all the answers

Which medication is associated with Vitamin B12 deficiency anemia?

<p>Metformin (C)</p> Signup and view all the answers

A patient with iron deficiency anemia exhibits several abnormal lab values. Which combination of results is most consistent with this condition?

<p>Decreased ferritin, increased TIBC, decreased hemoglobin (C)</p> Signup and view all the answers

A 17-year-old African American male is admitted with a sickle cell crisis and reports severe pain. His O2 saturation is 90% on room air. After applying oxygen, which intervention is the most appropriate next step?

<p>Start an IV and administer fluids. (A)</p> Signup and view all the answers

A patient is diagnosed with thrombocytopenia. Which condition is least likely to be associated with thrombocytopenia?

<p>Autoimmune disorders (B)</p> Signup and view all the answers

A patient with thrombocytopenia is being monitored for signs and symptoms of internal bleeding. Which assessment finding would be the most concerning and require immediate intervention?

<p>Sudden drop in blood pressure accompanied by increased heart rate (D)</p> Signup and view all the answers

A patient with anemia of chronic disease is also diagnosed with COPD. How does COPD contribute to anemia of chronic disease?

<p>Chronic inflammation associated with COPD leads to increased hepcidin production, limiting iron availability. (B)</p> Signup and view all the answers

Which statement best describes the pathophysiology of sickle cell anemia and its impact on red blood cells?

<p>A genetic mutation causes red blood cells to assume a rigid, sickle shape, leading to vaso-occlusion. (A)</p> Signup and view all the answers

A patient with peripheral artery disease (PAD) experiences leg pain during exercise that is relieved by rest. Which of the following strategies would be most effective in managing this symptom?

<p>Encouraging regular, supervised exercise to improve collateral circulation. (C)</p> Signup and view all the answers

A patient with a hemoglobin level of 6.7 g/dL is experiencing significant fatigue and shortness of breath. After notifying the physician, which intervention is the most appropriate?

<p>Initiate oxygen therapy and prepare the patient for a possible blood transfusion. (B)</p> Signup and view all the answers

Flashcards

Chronic Kidney Disease (CKD)

Progressive, irreversible loss of kidney function, marked by kidney damage or low GFR (<60 mL/min/1.73m^2 for >3 months).

Leading Causes of CKD

Diabetes (50% of cases) and Hypertension (25% of cases).

Glomerular Filtration Rate (GFR)

Calculated from creatinine, age, body size, and gender; measures kidney function.

Common Clinical Manifestations of CKD

Anxiety, hypertension, anorexia, anemia, fatigue, puritis, paresthesia.

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Uremia in CKD

Toxic waste buildup in blood due to kidneys' inability to properly filter urine.

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Treatment of Hyperkalemia in CKD

Restriction of high-potassium foods/drugs, sodium polystyrene sulfonate, IV glucose and insulin, IV calcium gluconate, and potentially dialysis.

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Antihypertensive Therapy in CKD

Weight loss, DASH diet, ACE inhibitors, ARBs, and diuretics; maintain BP around 130/80.

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BPH Pathophysiology

Enlargement of the prostate, obstructing the urethra and hindering urine flow.

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BPH Clinical Manifestations

Difficulty starting urine flow, weak stream, frequent interruptions, dribbling, urgency, nocturia, and incontinence.

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BPH Diagnosis

Digital rectal exam (DRE) to feel the prostate & PSA blood test to rule out tumor marker.

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BPH Complications

Acute urinary retention, bladder stones, infection, hydronephrosis, postrenal acute kidney injury, pyelonephritis.

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5-alpha Reductase Inhibitors

Medication that blocks hormone changes that lead to enlarged prostate, taking 3-6 months to work.

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Alpha-Adrenergic Blockers

Medication that relaxes smooth muscle in the prostate by acting on alpha receptors. Takes 2 weeks-4 months for results.

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TURP

Most common BPH surgery where inner prostate is removed to improve urine flow.

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Prostate Cancer Screening

Yearly digital rectal exams (DRE) starting at age 45-50 and Prostate Specific Antigen (PSA) blood test.

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Prostate Cancer Symptoms

Mimic BPH symptoms, hematuria, hemospermia, pain, rectal pain/cramping, tenesmus.

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COPD Pathophysiology

A progressive respiratory disease with airflow limitation and inflammation that is not fully reversible, usually a combination of emphysema and chronic bronchitis.

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COPD Causes

Smoking (80-90% of cases), occupational factors, air pollution, and Alpha-1 antitrypsin deficiency.

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Spirometry in COPD

Spirometry measures lung volumes and airflow to diagnose and stage COPD.

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Forced Vital Capacity (FVC)

The amount of air exhaled during a forced expiration.

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FEV1

Volume of air expired in the first second of maximal expiration, indicating how quickly the lungs can empty.

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Pica

Compulsion to eat non-food items; may indicate iron deficiency.

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Anemia: Paresthesia

Neurological issues from anemia; causes numbness or tingling in extremities.

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Anemia: Glossitis

Painful, smooth, red tongue with cracks at the corners of the mouth, often seen in iron deficiency anemia.

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Anemia: Koilonychias

Spooning and thinning of the nails, often indicative of iron deficiency.

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Vitamin C and Iron

Increases iron absorption; important to take with iron supplements.

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Lhermitte Sign

Electric shock sensation down the spine upon neck flexion, related to demyelination from B12 deficiency.

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Folate Insufficiency Risks

Associated with gastric bypass, alcoholism, some meds; may present with confusion.

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Nursing considerations for Iron Supplement

Give with ascorbic acid; causes dark stools; watch for constipation

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Erythropoietin Considerations

Only given if HGB is less than 10 mg%; monitor for hypertension and hypercoagulability.

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Sickle Cell Disease

Inherited disorder causing RBCs to sickle in low oxygen, leading to hemolysis and organ damage.

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Types of Sickle Cell Crises

Vaso-occlusive, aplastic, sequestration, and hemolytic. Vaso-occlusive is most common leading to tissue hypoxia and pain.

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Triggers for Sickle Cell Crisis

Hypoxemia (low oxygen), dehydration, cold temperatures, infection, and low atmospheric oxygen levels.

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Hypoxemia Consequence

Inadequate oxygen to tissues, causing pain and potential organ damage.

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Aplastic Crisis

A type of crisis where the bone marrow temporarily stops producing red blood cells.

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Sequestration Crisis

Sudden trapping of large amounts of blood in the spleen leading to hypovolemic shock.

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Dactylitis

Swelling of fingers and toes, common in young children with sickle cell anemia.

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Sickle Cell Disease Management

Measures to identify and avoid triggers, prevent hypoxemia, maintain healthy lifestyle, manage pain, and provide supportive care.

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Thrombocytopenia

Low platelet count, increasing the risk of bleeding.

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Medications Causing Thrombocytopenia

Anticoagulants, fibrinolytics, platelet inhibitors, NSAIDs, antibiotics, and drugs affecting clotting factors or Vitamin K.

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Thrombocytopenia: Activity Precautions

Activities that could cause bruising or bleeding should be avoided to minimize risks of complications.

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Thrombocytopenia: Oral Hygiene

A soft-bristled toothbrush is essential to prevent gum bleeding in individuals with thrombocytopenia.

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Thrombocytopenia: Monitor for Melena

Monitoring for signs of internal bleeding, such as black stools (melena), is crucial for early detection and intervention.

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Thrombocytopenia: Avoid Aspirin

Aspirin should be avoided due to its antiplatelet effects, which can increase the risk of bleeding.

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Thrombocytopenia: Razor Type

Using an electric razor minimizes the risk of cuts and bleeding compared to traditional razors.

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Iron Deficiency Anemia

Most common anemia, caused by insufficient iron for hemoglobin production, leading to reduced RBCs.

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Anemia of Chronic Disease (CKD related)

Anemia resulting from inadequate erythropoietin production by the kidneys, common in CKD patients.

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Sickle Cell Crisis

A painful episode in sickle cell disease caused by sickled red blood cells obstructing blood flow, leading to tissue hypoxia and severe pain.

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Benign Prostatic Hyperplasia (BPH)

Enlargement of the prostate gland, leading to urinary symptoms.

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Prostate-Specific Antigen (PSA)

A blood test to screen for prostate cancer, though it can also be elevated in BPH and other conditions.

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Digital Rectal Exam (DRE)

A physical exam to assess the size and texture of the prostate gland.

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Transfusion Reaction

A severe reaction to a blood transfusion where the body attacks the transfused blood cells.

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Prostate Cancer Risk Factors

Genetic disorder more common in African Americans and older age.

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PSA as Gold Standard?

PSA levels are not definitive; elevated levels require further investigation to rule out other causes before diagnosing prostate cancer.

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Iron Deficiency Anemia Lab Findings

Decreased ferritin, decreased hemoglobin, and increased TIBC are expected findings in iron deficiency anemia.

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Initial Intervention for Sickle Cell Crisis

Start an IV and administer fluids.

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Sickle Cell Anemia - True Statements

Sickled red blood cells can clump together and block blood flow, patients with sickle cell disease should avoid high altitudes and are at increased risk for infections, and Hydroxyurea is a medication used to reduce sickling episodes.

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Claudication

Pain in legs when walking that is relieved by rest.

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Internal Bleeding Signs in Thrombocytopenia

Black, tarry stools, petechiae and bruising, hematuria, and hypotension.

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Priority Intervention for Hemoglobin of 6.7 g/dL

Prepare for a blood transfusion.

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Clinical Manifestations of Anemia

Fatigue, pallor, tachypnea, and spoon-shaped fingernails.

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Study Notes

Peripheral Arterial Disease (PAD) Diagnosis

  • Occurs when symptoms are present by Ankle-brachia index (ABI) Ankle BP/Brachial BP.
  • If ABI is greater than 1.30, this indicates noncompressible arteries (stiff arteries).
  • Normal ABI range is 1 to 1.29.
  • Borderline PAD range of ABI is 0.91 to 0.99.
  • Mild to moderate PAD, the ABI range is 0.41 to 0.90.
  • Severe PAD range of ABI is 0 to 0.4.

Nutritional Anemia: Clinical Assessment

  • Neurologic symptoms include paresthesia.
  • Glossitis – painful, smooth, red tongue, cracks in corners of the mouth are associated with iron deficiency anemia.
  • Koilonychias – Spooning and thinning nails.

Nursing Interventions:

  • Decrease/minimize blood loss and increase dietary iron and vitamin C including dark green leafy vegetables, meats, and iron-fortified cereal/bread.
  • When giving iron supplements, report any shortness of breath, increased fatigue, and bleeding (especially in the stool).

Vitamin B12 Anemia

  • More likely to cause neurological and psychiatric dysfunction due to demyelination of nerves.
  • Symptoms include paresthesia (numbness and tingling in hands and feet).
  • Lhermitte sign is an electric shock sensation that occurs with neck flexion when having B12 deficiency.
  • Consume dietary sources of B12, including meat, dairy, and seafood/ eggs
  • B12 can be given through supplements, oral, or injection

Folic Acid Anemia

  • Folate insufficiency is associated with gastric bypass surgery, Whipple, alcoholism (pancytopenia), oral contraceptives, metformin, and some chemotherapy.
  • Can increase metabolism of Dilantin, increasing the risk of seizures.
  • Also commonly has neuro symptoms of confusion or disorientation Folic acid supplements are an intervention.

Managing Anemia

  • Ensure adequate safe perfusion comes first.
  • IV therapy with blood transfusions, protein/coagulation factors, and/or crystalloid fluids (lactate ringers).
  • Remove underlying cause, and reduce oxygen demands.
  • Administer bone marrow stimulants (erythropoietin): Only when HGB is less than 10 mg.
  • Monitor for hypertension and hypercoagulability.
  • Ensure there are adequate ferritin and iron precursors present.
  • Immunosuppressives (if etiology is autoimmune destruction of cells.)
  • Can administer a blood and marrow transplant (BMT)/hematopoietic stem cell transplant (HSCT) (if anemia is permanent stem cell damage).

Sickle Cell Anemia

  • Sickling of the RBC in the presence of hypoxemia due to abnormal Hemoglobin S DNA structure.
  • Sickled cells are longer and stiffer, with a very short lifespan (20 days compared to 120 days) which has triggered by hypoxemia. -Some reverses with correction of hypoxemia, others remain sickled and are removed by extra-splenic hemolysis.
  • Autosomal recessive inheritance

Medical Emergency

  • Absent pulses OR sensations with RED level assessment required!

Blood Transfusion Reactions

  • Allergic - facial flushing, hives/rash (mild); increased anxiety, wheezing, and dyspnea, decreased BP (severe)
  • Febrile – fever, chills, anxiety, HA, tachycardia, tachypnea
  • Hemolytic – hemoglobinuria, chest pain, apprehension, low back pain, chills, fever, tachycardia, decreased BP, increased RR
  • Contaminated product/sepsis reactions

Oxygen Toxicity

  • Long term lung adaptations result is pts with COPD having impaired stimulus to breathe through C02
  • Interventions still require oxygen but it must be monitored closely
  • Be are of potential complications like;
  • Barotrauma
  • Gastric pressure
  • Delirium/Falls
  • Infection and Air quality (Triggers)

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Description

This lesson covers key aspects of chronic kidney disease (CKD), including classification based on GFR, associated lab findings, and the use of ACE inhibitors/ARBs. It also addresses symptom management, particularly pruritus, and precautions when using medications like sodium polystyrene sulfonate. Dietary modifications for CKD patients are also discussed.

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