Nephrology Quiz: Acute and Chronic Renal Failure

10 Questions

What is the primary symptom of Nephrotic syndrome?

Proteinuria

What is the term for the inflammation of the glomeruli leading to protein leakage from the blood into the urine?

Glomerulonephritis

Which of the following is NOT a primary cause of Nephrotic syndrome?

Rapidly progressive bronchiolitis

What is the term for the scarring of the glomeruli, which can lead to Nephrotic syndrome?

Focal segmental glomerulosclerosis

Which of the following is a secondary cause of Nephrotic syndrome?

Systemic lupus erythematosus

What is the term for the obstruction of the glomerular capillary lumen by viral antigens?

HIV-associated nephropathy

What is the primary goal of dietary modification in Nephrotic syndrome management?

Restricting animal protein intake

Which of the following medications is commonly used to treat Nephrotic syndrome?

Corticosteroids

What is the term for the daily monitoring of fluid intake and output?

Intake and output monitoring

What is the term for the inflammation of the glomeruli, characterized by the deposition of antibodies in their membranes?

Membranoproliferative glomerulonephritis

Study Notes

Renal Failure

Acute Renal Failure (ARF) is a sudden decline in kidney function, usually reversible.
Diagnosed using KDIGO criteria (2012): creatinine increase of 0.3 mg/dL in 48 hours, creatinine increase to 1.5 times baseline within last 7 days, urine volume less than 0.5 mL/kg per hour for 6 hours.
Chronic Renal Failure (CRF) is a persistent impairment of kidney function, often progressive, and may require renal replacement therapy.

Aetiology of Acute Renal Failure

Prerenal (approximately 60%): hypotension, volume contraction, severe organ failure, NSAIDs, ARBs, ACEI, and cyclosporine.
Intrarenal (approximately 35%): acute tubule necrosis, acute interstitial nephritis, connective tissue disorders, arteriolar insults, fat emboli, and intrarenal deposition.
Postrenal (approximately 5%): extrinsic compression, intrinsic obstruction, and decreased function.

Chronic Renal Failure

Diabetes mellitus, especially type 2, is the most frequent cause of End-Stage Renal Disease (ESRD).

Nephrotic Syndrome

Inflammation of the glomeruli leading to protein leakage from the blood into the urine (proteinuria).
Results in low levels of protein (albumin) in the blood (hypoalbuminemia).
Edema, high levels of cholesterol and other lipids (fats) in the blood (hyperlipidemia).

Causes of Nephrotic Syndrome

Primary causes: minimal change disease, focal segmental glomerulosclerosis, membranous glomerulonephritis, membranoproliferative glomerulonephritis, and rapidly progressive glomerulonephritis.
Secondary causes: diabetic nephropathy, systemic lupus erythematosus, syphilis, hepatitis B, Sjögren's syndrome, HIV, amyloidosis, vasculitis, cancer, genetic disorders, and drugs.