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Questions and Answers
What is the definition of chronic inflammation?
What are the two types of chronic inflammation based on the cause?
Which type of granuloma is characterized by the chief reactive cell being an activated macrophage?
Which condition is an example of infective granuloma?
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What is the distinct pattern of chronic inflammation in which tiny granules fuse to form a tumor-like mass?
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Which condition is an example of non-infective granuloma?
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Which type of wound healing occurs when wound edges cannot be apposed?
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Which type of cell does not proliferate under normal conditions but only when there is a need?
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What is the process of replacement of the damaged tissue by granulation tissue which matures to fibrous tissue?
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Which factor delays wound healing and leads to more granulation tissue and scarring?
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What is the best example of healing by regeneration in humans?
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Which cells are continuously dividing throughout life to replace damaged cells?
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What type of inflammation heals by organization?
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Which type of repair involves the replacement of injured cells by cells of the same type?
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Study Notes
Chronic Inflammation
- Defined as a prolonged inflammatory response characterized by simultaneous tissue destruction and healing.
- Can lead to various diseases and conditions if unresolved.
Types of Chronic Inflammation
- Infective Chronic Inflammation: Resulting from persistent infections, such as those caused by bacteria or viruses.
- Non-Infective Chronic Inflammation: Triggered by factors like autoimmune diseases or chronic irritants.
Granulomas
- Caseating Granuloma: Activated macrophages are the primary reactive cells, often seen in infections like tuberculosis.
- Infective Granuloma Example: Tuberculosis is a classic example related to caseating granulomas.
Patterns of Chronic Inflammation
- Distinct pattern includes granulomatous inflammation, where small granules fuse into a tumor-like mass, termed a granuloma.
Non-Infective Granuloma Example
- Sarcoidosis serves as a prominent example of non-infective granulomas, characterized by the collection of immune cells.
Wound Healing
- Secondary Intention Healing: Occurs when wound edges cannot be apposed, usually resulting in more extensive scarring.
- Replacement of damaged tissue by granulation tissue evolving into fibrous tissue is termed organization.
- Factors like infection or poor nutrition can delay wound healing and increase granulation tissue formation.
Regeneration and Cell Division
- Best example of healing by regeneration in humans is liver regeneration after partial hepatectomy.
- Stem cells are responsible for continuous cell division, replacing damaged cells throughout life.
Types of Inflammation and Repair
- Organization: Healing process in inflammation characterized by the formation of granulation tissue during chronic inflammation.
- Tissue Repair: Involves replacement of injured cells by the same type, known as regeneration.
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Description
Test your knowledge about chronic inflammation, tissue injury, and repair processes. Learn about the causes and types of chronic inflammation, including de novo and on top of acute inflammation.
