week 7 Cholinergic Drugs & Alzheimer's Disease Meds

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Questions and Answers

Which is a cardiovascular effect of cholinergic drugs?

  • Tachycardia
  • Bradycardia (correct)
  • Vasoconstriction
  • Palpitations

How are most direct-acting cholinergic drugs mainly used?

  • For the diagnosis and treatment of myasthenia gravis
  • Orally in preparation for ocular surgery
  • As antidotes for anticholinergic poisoning
  • Topically to reduce intraocular pressure (correct)

When an overdose of an intravenous cholinergic drug occurs, which drug, administered promptly, can reverse a cholinergic crisis?

  • atenolol (Tenormin)
  • dobutamine
  • atropine sulphate (correct)
  • bethanechol (Duvoid®)

A patient has had abdominal surgery and is being discharged on a cholinergic drug to assist in increasing gastrointestinal peristalsis. Which therapeutic effects should the nurse teach the patient to watch for?

<p>Passage of flatus (A)</p> Signup and view all the answers

A patient has been newly diagnosed with myasthenia gravis. What important information should the nurse give this patient about the administration of cholinergic drugs?

<p>The medication should be taken 30 minutes before eating, to improve swallowing and chewing. (C)</p> Signup and view all the answers

Which drug is considered to be the antidote for anticholinergic poisoning and for poisoning by organophosphates and carbonates, such as those in common insecticides?

<p>physostigmine (D)</p> Signup and view all the answers

A patient diagnosed 3 months ago has mild memory loss. She will be receiving donepezil (Aricept). which statement accurately describes the drug's actions?

<p>It may help to improve the symptoms of Alzheimer's disease. (C)</p> Signup and view all the answers

A patient has been taking donepezil (Aricept) for 2 weeks as part of the treatment for early stages of Alzheimer's disease. The patient's daughter calls the physician's office, upset because her mother has not shown any improvement. What is the nurse's best response to the patient's daughter?

<p>&quot;It may take up to 6 weeks to see an improvement.&quot; (C)</p> Signup and view all the answers

The desired effects of cholinergic drugs come from stimulation of which receptors?

<p>Muscarinic (B)</p> Signup and view all the answers

A patient wants to begin taking ginkgo for memory enhancement. The nurse should warn this patient about possible drug interactions with which substances?

<p>Aspirin, any nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin (Coumadin®), and heparin (D)</p> Signup and view all the answers

Match the following effects to the correct stimulation: a. Muscarinic stimulation b. Nicotinic stimulation c. Both muscarinic stimulation and nicotinic stimulation

<p>Pupil constriction = Both muscarinic stimulation and nicotinic stimulation Increased heart rate = Nicotinic stimulation Decreased blood pressure = Muscarinic stimulation</p> Signup and view all the answers

The nurse is about to administer a STAT dose of atropine sulphate to a patient who is experiencing a symptomatic cardiac dysrhythmia. During administration of this drug, the nurse monitors the patient closely for which adverse effect?

<p>Tachycardia (D)</p> Signup and view all the answers

How long can a scopolamine patch prevent motion sickness?

<p>3 days (A)</p> Signup and view all the answers

Which condition is appropriate for treatment with a cholinergic-blocking drug?

<p>Irritable bowel disease (C)</p> Signup and view all the answers

Which medication is the antidote to severe cases of atropine overdose?

<p>physostigmine (B)</p> Signup and view all the answers

A 72-year-old male has a new prescription for an anticholinergic. He is an active man and enjoys outdoor activities such as hiking, golfing, and doing yard work. During a teaching session about his drug therapy, the nurse should emphasize that

<p>he should take measures to reduce the occurrence of heat stroke during his activities. (C)</p> Signup and view all the answers

When administering an anticholinergic drug, the nurse expects the patient will experience which adverse effect?

<p>Dry mouth (A)</p> Signup and view all the answers

For which condition is the drug oxybutynin (Ditropan) used?

<p>As an antispasmodic for neurogenic bladder (D)</p> Signup and view all the answers

What is the advantage of using tolterodine (Detrol®) for urinary incontinence as compared with other drugs?

<p>The incidence of dry mouth is much lower with tolterodine. (B)</p> Signup and view all the answers

The nurse working in a preoperative holding unit anticipates an order to give which anticholinergic medication to a newly admitted patient?

<p>glycopyrrolate (C)</p> Signup and view all the answers

Solifenacin succinate (Vesicare®) is contraindicated for patients with which condition?

<p>Glaucoma and severe constipation (A)</p> Signup and view all the answers

Atropine is appropriate for which patients? (Select all that apply.)

<p>A patient who requires preoperative reduction of salivary and gastrointestinal secretions myasthenia gravis (B), A patient who has suddenly developed symptomatic bradycardia, with a heart rate of 32 beats per minute (C), A patient with severe diarrhea (E)</p> Signup and view all the answers

Flashcards

Cardiovascular effect of cholinergic drugs?

Decreased heart rate and vasodilation.

How are most direct-acting cholinergic drugs mainly used?

Topically to reduce intraocular pressure in patients with glaucoma.

Antidote for intravenous cholinergic drug overdose?

Atropine sulphate

Therapeutic effects to watch for when taking cholinergic drug to assist in increasing gastrointestinal peristalsis?

Increase in bowel sounds, passage of flatus, and bowel movements.

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Administration of cholinergic drugs for myasthenia gravis?

Take the medication 30 minutes before eating, to improve swallowing and chewing.

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Antidote for anticholinergic poisoning?

Physostigmine.

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What accurately describes the Donepezil drug's actions?

It may help to improve the symptoms of Alzheimer's disease.

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Response to patient's daughter?

It may take up to 6 weeks to see an improvement.

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The desired effects of cholinergic drugs come from stimulation of which receptors?

Muscarinic

Signup and view all the flashcards

Possible drug interactions with ginkgo?

Aspirin, any nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin (Coumadin®), and heparin

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Study Notes

  • Cholinergic drugs can cause bradycardia and vasodilation, leading to a decreased heart rate.
  • Direct-acting cholinergic drugs help reduce intraocular pressure in patients with glaucoma or those undergoing ocular surgery when applied topically.
  • With an intravenous cholinergic drug overdose, promptly administer atropine sulfate to reverse the cholinergic crisis.
  • An increased passage of flatus indicates increased gastrointestinal peristalsis in patients experiencing a postoperative decrease in gastrointestinal peristalsis.
  • Myasthenia gravis patients should take cholinergic drugs 30 minutes before eating to improve swallowing and chewing.
  • Physostigmine is considered to be the antidote for anticholinergic poisoning and poisoning by organophosphates and carbonates, commonly found in insecticides.
  • Donepezil treats mild to moderate dementia in Alzheimer's disease and may improve symptoms.
  • It may take up to 6 weeks to see improvement when taking donepezil for Alzheimer's disease.
  • Desired effects of cholinergic drugs come from muscarinic receptor stimulation, while undesirable adverse effects come from nicotinic receptor stimulation.
  • Ginkgo may interact with aspirin, NSAIDs, warfarin, heparin, anticonvulsants, ticlopidine, clopidogrel, dipyridamole, and tricyclic antidepressants.
  • Both muscarinic and nicotinic stimulation causes pupil constriction.
  • Nicotinic stimulation leads to an increased heart rate.
  • Muscarinic stimulation leads to a decreased blood pressure.
  • Tachycardia is one of the cardiovascular effects of cholinergic blockers.
  • A scopolamine patch can prevent motion sickness for 3 days.
  • Cholinergic-blocking drugs may be used to treat irritable bowel disease.
  • Glaucoma, myasthenia gravis, and genitourinary obstruction are contraindications to the use of cholinergic-blocking drugs.
  • Physostigmine is the antidote to an atropine overdose in clients who show extreme delirium or agitation and who could injure themselves.
  • Older adult patients who take an anticholinergic should be reminded that they are at a greater risk for suffering a heat stroke because of decreased sweating and loss of normal heat-regulating mechanisms.
  • When administering an anticholinergic drug, the patient will experience dry mouth is a common adverse effect.
  • Oxybutynin is used as an antispasmodic for the treatment of neurogenic and overactive bladder conditions.
  • The incidence of dry mouth is much lower with tolterodine as compared with other drugs.
  • Glycopyrrolate is an anticholinergic drug that can be used to control secretions during surgery.
  • Solifenacin succinate is contraindicated for patients with glaucoma, certain gastrointestinal and genitourinary tract problems, severe constipation, and urinary retention.
  • Atropine is appropriate for treating symptomatic bradycardia certain other cardiac conditions, preoperatively control secretions during surgery, and to decrease intestinal motility.

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