Questions and Answers
Which of the following are contraindications for Galantamine (Razadyne)?
Galantamine is indicated for severe dementia.
False
What are the key side effects of Galantamine?
Chest pain, anorexia, incontinence, tremor.
What is the primary action of Galantamine?
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Patients with ________ should use caution with Galantamine.
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Which of the following are potential interactions with Galantamine?
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What should nursing responsibilities include when administering Galantamine?
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Match the following categories related to Galantamine with their descriptions:
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Study Notes
Galantamine (Razadyne) Overview
- A cholinergic medication classified as an anti-Alzheimer's drug.
- Available in both oral and extended-release formulations.
Indications
- Primarily used to treat mild to moderate dementia associated with Alzheimer’s disease.
Side Effects
- Common side effects include fatigue, dizziness, headache, syncope, and bradycardia.
- Other significant effects may include chest pain, anorexia, diarrhea, dyspepsia, and nausea.
- Risk of bladder outflow obstruction, incontinence, tremors, and weight loss.
Drug Action
- Works by inhibiting cholinesterase, thus increasing cholinergic function.
- Aims to lower cognitive impairment and improve symptoms related to dementia.
Nursing Responsibilities
- Essential to monitor patients for signs of bradycardia.
- Regular assessment can help mitigate risks associated with cardiac function.
Contraindications
- Not recommended for patients with hypersensitivity or severe hepatic and renal impairment.
- Avoid use in those with uncontrolled conditions that could exacerbate risks.
Cautions
- Exercise caution in patients with heart issues, as it may lead to a slowed heart rate.
- History of ulcer disease or gastrointestinal bleeding poses additional risks.
- Concurrent use of NSAIDs can increase chances of cardiovascular mortality.
Drug Interactions
- Increases neuromuscular blockade effects of succinylcholine, leading to muscle weakness.
- May enhance the effects of other cholinesterase inhibitors or cholinergic agents like Bethanechol.
- Decreases the effectiveness of anticholinergic medications.
- Cytochrome P450 inhibitors (e.g., Ketoconazole, Paroxetine, Amitriptyline, Fluvoxamine, Quinidine) can elevate galantamine's effects and blood levels.
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Test your knowledge on Galantamine (Razadyne) with these flashcards. Explore key points related to its classification, indications, and important precautions. Ideal for healthcare professionals and students studying pharmacology.
