Cholinergic Agonists and Antagonists Quiz
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Questions and Answers

What is a primary effect of organophosphorous compounds on the body?

  • Decrease in heart rate
  • Inhibition of serotonin reuptake
  • Permanent nerve regeneration
  • Increase in acetylcholine levels (correct)
  • Which of the following symptoms is associated with muscarinic effects of organophosphate poisoning?

  • Muscle paralysis
  • Increased appetite
  • Difficulty breathing (correct)
  • Pupil dilation
  • What treatment is essential for managing organophosphorous poisoning?

  • Immediate surgery
  • Increasing physical activity
  • Administration of atropine (correct)
  • Dietary modifications
  • Chronic exposure to organophosphorous compounds can lead to which condition?

    <p>Neuropathy and demyelination</p> Signup and view all the answers

    Which strategy is NOT part of the treatment for organophosphorous poisoning?

    <p>Raising blood pressure</p> Signup and view all the answers

    What is the primary action of atropine at muscarinic receptors?

    <p>Block acetylcholine activity</p> Signup and view all the answers

    Which of the following effects is associated with atropine on the eye?

    <p>Mydriasis (pupil dilation)</p> Signup and view all the answers

    What is one of the cardiovascular effects of atropine?

    <p>Progressive increase in heart rate</p> Signup and view all the answers

    What adverse reaction can result from atropine use in patients with angle-closure glaucoma?

    <p>Dangerous rise in intraocular pressure</p> Signup and view all the answers

    Which symptom is most commonly associated with the use of atropine due to its effect on salivary glands?

    <p>Dryness of the mouth (xerostomia)</p> Signup and view all the answers

    What is the primary mechanism of action for indirect-acting cholinergic agonists?

    <p>Inhibit acetylcholinesterase activity</p> Signup and view all the answers

    Which type of cholinergic receptor is primarily activated in the heart to decrease heart rate?

    <p>Muscarinic receptors</p> Signup and view all the answers

    Which of the following statements is true regarding the autonomic control of organs?

    <p>Both systems provide dual innervation but with different outcomes</p> Signup and view all the answers

    In myasthenia gravis management, which type of drug is typically used to enhance the availability of acetylcholine at the neuromuscular junction?

    <p>Anticholinesterase agents</p> Signup and view all the answers

    What is the effect of cholinergic agonists on blood vessels?

    <p>Causes vasodilatation</p> Signup and view all the answers

    Which of the following is a direct acting cholinergic agonist?

    <p>Bethanechol</p> Signup and view all the answers

    Which organ system primarily uses adrenergic receptors to mediate its functions?

    <p>Cardiovascular system</p> Signup and view all the answers

    What is a common adverse reaction to cholinergic agonists?

    <p>Miosis</p> Signup and view all the answers

    Which of the following actions is caused by muscarinic receptors?

    <p>Bronchoconstriction</p> Signup and view all the answers

    What effect does pilocarpine have on the eyes?

    <p>Causes miosis</p> Signup and view all the answers

    Which therapeutic use is specifically associated with bethanechol?

    <p>Post-operative non-obstructive urinary retention</p> Signup and view all the answers

    Which statement accurately describes neostigmine?

    <p>It is a synthetic anticholinesterase drug.</p> Signup and view all the answers

    What side effect may occur with the use of physostigmine?

    <p>Convulsions</p> Signup and view all the answers

    Which of the following is a characteristic of cholinergic agonists?

    <p>Increased muscle contraction at the neuromuscular junction</p> Signup and view all the answers

    Which substance is primarily used to manage Myasthenia Gravis?

    <p>Neostigmine</p> Signup and view all the answers

    What is a notable action of nicotine at the ganglia?

    <p>Stimulation of both sympathetic and parasympathetic ganglia</p> Signup and view all the answers

    Study Notes

    Cholinergic Agonist

    • Cholinergic agonists mimic the effects of acetylcholine
    • Classified by direct and indirect action
    • Direct-acting agonists directly bind to cholinergic receptors
    • Indirect-acting agonists inhibit acetylcholinesterase, increasing acetylcholine levels
    • Adverse reactions include nausea, vomiting, diarrhea, and bradycardia
    • Therapeutic uses include treatment of myasthenia gravis, glaucoma, and urinary retention

    Cholinergic Antagonist

    • Cholinergic antagonists block the effects of acetylcholine
    • Classified by their actions on muscarinic and nicotinic receptors
    • Muscarinic antagonists block muscarinic receptors, preventing the activation of glands and smooth muscles
    • Nicotinic antagonists block nicotinic receptors, preventing muscle contractions
    • Adverse reactions include dry mouth, blurred vision, constipation, and urinary retention
    • Therapeutic uses include treatment of peptic ulcer disease, asthma, and glaucoma

    Myasthenia Gravis

    • Autoimmune disorder characterized by muscle weakness
    • Antibodies attack acetylcholine receptors at the neuromuscular junction
    • Symptoms include fluctuating weakness in muscles of the eyes, face, mouth, and throat
    • Management includes administration of anticholinesterase agents, corticosteroids, and immunosuppressant therapies, and in some cases thymectomy

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    Description

    Test your knowledge on cholinergic agonists and antagonists, their classifications, actions, and therapeutic uses. This quiz covers essential information about the effects of acetylcholine and relevant adverse reactions. Perfect for students in pharmacology or related fields.

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