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Questions and Answers
Which enzyme is responsible for the synthesis of acetoacetyl CoA?
Which enzyme is responsible for the synthesis of acetoacetyl CoA?
- Acetoacetyl CoA synthase (thiolase) (correct)
- HMG CoA reductase
- Kinase
- HMG CoA synthase
What is the rate-limiting step in the synthesis of cholesterol?
What is the rate-limiting step in the synthesis of cholesterol?
- HMG CoA synthase
- Squalene synthase
- Epoxidase
- HMG CoA reductase (correct)
Which molecule is formed by the condensation of isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DPP)?
Which molecule is formed by the condensation of isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DPP)?
- HMG CoA
- Mevalonate
- Squalene
- Farnesyl pyrophosphate (FPP) (correct)
Which enzyme is responsible for the oxidation of squalene to squalene epoxide?
Which enzyme is responsible for the oxidation of squalene to squalene epoxide?
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What is the first steroid molecule produced in the cholesterol synthesis pathway?
What is the first steroid molecule produced in the cholesterol synthesis pathway?
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Study Notes
Enzymes and Molecules in Cholesterol Synthesis
- Acetoacetyl CoA is synthesized by the enzyme HMG-CoA synthase.
Rate-Limiting Step
- The rate-limiting step in cholesterol synthesis is the conversion of HMG-CoA to mevalonate, catalyzed by the enzyme HMG-CoA reductase.
Isoprenoid Molecules
- The condensation of isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DPP) forms the molecule geranyl pyrophosphate.
Squalene Oxidation
- The enzyme squalene epoxidase is responsible for the oxidation of squalene to squalene epoxide.
First Steroid Molecule
- The first steroid molecule produced in the cholesterol synthesis pathway is lanosterol.
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Description
Test your knowledge of the first steps in cholesterol synthesis with this quiz. Challenge yourself with questions about the condensation of acetyl CoA, HMG CoA synthesis, and the synthesis of mevalonate.
