Podcast
Questions and Answers
What is the purpose of adjuvant chemotherapy?
What is the purpose of adjuvant chemotherapy?
- To maintain remission in cancer patients
- To attack micro metastases after surgery or radiation (correct)
- To provide supplemental treatment during radiation therapy
- To shrink the cancer prior to surgery
What is a common resistance mechanism developed by tumor cells against chemotherapy drugs?
What is a common resistance mechanism developed by tumor cells against chemotherapy drugs?
- Increased activation of the drug
- Enhanced drug uptake
- Reduced target enzyme concentration
- Decreased accumulation of drug (correct)
How is drug dosage usually calculated for chemotherapy treatment?
How is drug dosage usually calculated for chemotherapy treatment?
- On the basis of body surface area (correct)
- By patient's age
- According to the patient's weight
- Based on the type of cancer
Which process contributes to the toxicity of chemotherapy in normal rapidly dividing cells?
Which process contributes to the toxicity of chemotherapy in normal rapidly dividing cells?
What type of kinetics is followed in the destruction of cancer cells by chemotherapeutic agents?
What type of kinetics is followed in the destruction of cancer cells by chemotherapeutic agents?
How does resistance to chemotherapy commonly develop?
How does resistance to chemotherapy commonly develop?
Why is combination chemotherapy more successful than single-drug treatment?
Why is combination chemotherapy more successful than single-drug treatment?
What is a characteristic of most chemotherapeutic agents' therapeutic index?
What is a characteristic of most chemotherapeutic agents' therapeutic index?
Which of the following is an adverse effect commonly associated with chemotherapy?
Which of the following is an adverse effect commonly associated with chemotherapy?
When are agents with similar dose-limiting toxicities combined safely during chemotherapy treatment?
When are agents with similar dose-limiting toxicities combined safely during chemotherapy treatment?
In which cells does chemotherapy toxicity often manifest due to their rapid proliferation?
In which cells does chemotherapy toxicity often manifest due to their rapid proliferation?
In which type of cancers is neo-adjuvant chemotherapy typically given?
In which type of cancers is neo-adjuvant chemotherapy typically given?
What is the primary mechanism of action of methotrexate (MTX) in cancer chemotherapy?
What is the primary mechanism of action of methotrexate (MTX) in cancer chemotherapy?
What is the enzyme that converts folic acid to its active, coenzyme form, tetrahydrofolic acid (FH4)?
What is the enzyme that converts folic acid to its active, coenzyme form, tetrahydrofolic acid (FH4)?
Apart from inhibiting DHFR, what other enzyme does pemetrexed inhibit?
Apart from inhibiting DHFR, what other enzyme does pemetrexed inhibit?
Which drug is primarily utilized in non-small cell lung cancer?
Which drug is primarily utilized in non-small cell lung cancer?
What is the role of leucovorin in relation to MTX inhibition?
What is the role of leucovorin in relation to MTX inhibition?
Which type of lymphoma is pralatrexate primarily used to treat?
Which type of lymphoma is pralatrexate primarily used to treat?
What is the mechanism of action of 5-FU in inhibiting DNA synthesis?
What is the mechanism of action of 5-FU in inhibiting DNA synthesis?
How does 5-FU produce its anticancer effect?
How does 5-FU produce its anticancer effect?
What is the main reason behind administering 5-FU intravenously?
What is the main reason behind administering 5-FU intravenously?
Which enzyme's elevated levels can lead to increased 5-FU catabolism?
Which enzyme's elevated levels can lead to increased 5-FU catabolism?
What can be a severe side effect in patients with DPD deficiency upon 5-FU administration?
What can be a severe side effect in patients with DPD deficiency upon 5-FU administration?
How is 5-FU eventually removed from the body following metabolism?
How is 5-FU eventually removed from the body following metabolism?
What is the mechanism of action of Ara-CTP?
What is the mechanism of action of Ara-CTP?
Why is Cytarabine not effective when given orally?
Why is Cytarabine not effective when given orally?
What is the main mechanism of action of Azacitidine?
What is the main mechanism of action of Azacitidine?
Which cancer type is Gemcitabine commonly used for?
Which cancer type is Gemcitabine commonly used for?
What is the fate of both cytarabine and ara-U in the body after metabolism?
What is the fate of both cytarabine and ara-U in the body after metabolism?
Why is Ara-CTP considered S-phase specific in its action?
Why is Ara-CTP considered S-phase specific in its action?
What enzyme catalyzes the hydrolysis of capecitabine to 5-FU?
What enzyme catalyzes the hydrolysis of capecitabine to 5-FU?
Which enzyme is primarily inhibited by 5-FU, and subsequently by capecitabine?
Which enzyme is primarily inhibited by 5-FU, and subsequently by capecitabine?
Which enzyme is responsible for the sequential phosphorylation of cytarabine in cells?
Which enzyme is responsible for the sequential phosphorylation of cytarabine in cells?
Which cancer type is Gemcitabine primarily used for?
Which cancer type is Gemcitabine primarily used for?
What is the major clinical use of cytarabine?
What is the major clinical use of cytarabine?
What is the nucleotide form of cytarabine that exerts cytotoxic effects?
What is the nucleotide form of cytarabine that exerts cytotoxic effects?
Which enzyme is concentrated primarily in tumors and catalyzes the final step in converting capecitabine to 5-FU?
Which enzyme is concentrated primarily in tumors and catalyzes the final step in converting capecitabine to 5-FU?
What is the mechanism of action for cytarabine in treating acute nonlymphocytic leukemia?
What is the mechanism of action for cytarabine in treating acute nonlymphocytic leukemia?
Which enzyme is NOT directly involved in the enzymatic reactions converting capecitabine to 5-FU?
Which enzyme is NOT directly involved in the enzymatic reactions converting capecitabine to 5-FU?
What is the cytotoxic form of cytarabine needed to exert its pharmacological effects?
What is the cytotoxic form of cytarabine needed to exert its pharmacological effects?
