10 Questions
What is a common side effect that patients should be counseled about?
Alopecia
What is the maximum total dose of doxorubicin at which cardiomyopathy occurs in less than 1% of women?
320 mg/m2
What is a side effect experienced by menstruating women?
Cessation of menses
What is the dose of epirubicin in the adjuvant setting?
100-120 mg/m2
What is the risk of cardiomyopathy with epirubicin at a dose of 100-120 mg/m2 compared to standard doxorubicin doses?
Equal
What is the primary goal of systemic adjuvant therapy in breast cancer treatment?
Disease-free survival and overall survival
Which of the following is NOT a type of systemic adjuvant therapy?
Radiation therapy
What is the name of the cytotoxic drug that is often used in combination with other drugs in adjuvant therapy of breast cancer?
All of the above
What is the benefit of chemotherapy in adjuvant breast cancer treatment?
Improved disease-free survival and overall survival
Which of the following cytotoxic drugs is NOT mentioned as being commonly used in combination in adjuvant therapy of breast cancer?
Vinorelbine
Study Notes
Chemotherapy Side Effects
- Alopecia and fatigue are common side effects of chemotherapy regimens and patients should be counseled about their likelihood.
- Menstruating women may experience a cessation of menses, which may or may not return.
- Deep Vein Thrombosis (DVT) has been reported in women receiving combination chemotherapy regimens.
- Doxorubicin-induced cardiomyopathy occurs in less than 1% of women who receive a total dose of less than 320 mg/m2.
- Epirubicin, at a dose of 100-120 mg/m2, has an equal chance of causing cardiomyopathy as standard doxorubicin doses when used in the adjuvant setting.
This quiz covers the common side effects of chemotherapy regimens, including alopecia, fatigue, and cardiomyopathy. It also discusses the impact on menstruating women and the risks associated with doxorubicin and epirubicin.
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