Podcast
Questions and Answers
What is the primary cause of cancer?
What is the primary cause of cancer?
- Mutations in somatic cells (correct)
- Inherited genetic diseases
- Accumulation of somatic and germline mutations
- Mutations in germline cells
Which drug inhibits Thymidylate synthase, a key enzyme in DNA synthesis?
Which drug inhibits Thymidylate synthase, a key enzyme in DNA synthesis?
- Bleomycin
- Pertuzumab
- Capecitabine (correct)
- Gemcitabine
Why is cancer mainly a disease of the aged?
Why is cancer mainly a disease of the aged?
- Genetic diseases affecting cell multiplication
- Due to mutations in the VEGF gene
- As a result of inherited germ-line mutations
- Because aged individuals accumulate multiple mutations over time (correct)
Which drug targets EGFR, a protein involved in cell signaling?
Which drug targets EGFR, a protein involved in cell signaling?
In cancer development, how many mutations are typically required for an individual cancer to arise?
In cancer development, how many mutations are typically required for an individual cancer to arise?
Which drug works as a Dihydrofolate reductase inhibitor?
Which drug works as a Dihydrofolate reductase inhibitor?
What is the mechanism of action of Docetaxel and Paclitaxel?
What is the mechanism of action of Docetaxel and Paclitaxel?
"BRCA1" and "BRCA2" gene mutations are associated with an increased risk of which type of cancer?
"BRCA1" and "BRCA2" gene mutations are associated with an increased risk of which type of cancer?
What is the primary mechanism of action of topoisomerase I inhibitors?
What is the primary mechanism of action of topoisomerase I inhibitors?
How do topoisomerase II inhibitors, like anthracyclines, exert their effects on cancer cells?
How do topoisomerase II inhibitors, like anthracyclines, exert their effects on cancer cells?
What is the role of topoisomerase II inhibitors after breaking the DNA chain?
What is the role of topoisomerase II inhibitors after breaking the DNA chain?
Which enzyme converts Irinotecan to its active form, SN-38?
Which enzyme converts Irinotecan to its active form, SN-38?
What distinguishes Epirubicin from other anthracyclines in terms of its chemical structure?
What distinguishes Epirubicin from other anthracyclines in terms of its chemical structure?
What happens when a DNA replication fork encounters a topotecan-stabilized cleavable complex?
What happens when a DNA replication fork encounters a topotecan-stabilized cleavable complex?
How do topoisomerase I inhibitors prevent DNA religation?
How do topoisomerase I inhibitors prevent DNA religation?
What is the key role of Topoisomerase I in DNA manipulation?
What is the key role of Topoisomerase I in DNA manipulation?
Which type of cancer is mentioned as one of the diseases that can regress with the use of Doxorubicin?
Which type of cancer is mentioned as one of the diseases that can regress with the use of Doxorubicin?
What is the primary cause of the cardiotoxic effects induced by the administration of Doxorubicin?
What is the primary cause of the cardiotoxic effects induced by the administration of Doxorubicin?
Etoposide, a non-intercalating Topoisomerase II inhibitor, is a semisynthetic derivative of which compound?
Etoposide, a non-intercalating Topoisomerase II inhibitor, is a semisynthetic derivative of which compound?
Why are mitotic inhibitors like Vinca Alkaloids used in cancer treatment?
Why are mitotic inhibitors like Vinca Alkaloids used in cancer treatment?
What is the primary function of Topoisomerase II?
What is the primary function of Topoisomerase II?
Which cancer type is commonly treated with Etoposide in combination with other chemotherapeutic agents?
Which cancer type is commonly treated with Etoposide in combination with other chemotherapeutic agents?
What is the main characteristic that makes Doxorubicin an effective antitumor agent?
What is the main characteristic that makes Doxorubicin an effective antitumor agent?
How do cancer cells differ from normal cells regarding sensitivity to mitotic inhibitors?
How do cancer cells differ from normal cells regarding sensitivity to mitotic inhibitors?
Which mechanism of action is shared by GnRH agonists and GnRH antagonist discussed in the text?
Which mechanism of action is shared by GnRH agonists and GnRH antagonist discussed in the text?
Which medication works by inhibiting CYP17A1 to reduce the production of androgens?
Which medication works by inhibiting CYP17A1 to reduce the production of androgens?
Among the nonsteroid antiandrogens discussed, which one acts as an antagonist of the androgen receptor?
Among the nonsteroid antiandrogens discussed, which one acts as an antagonist of the androgen receptor?
Which drug is a proteasome inhibitor approved by the U.S. FDA for treating relapsed multiple myeloma?
Which drug is a proteasome inhibitor approved by the U.S. FDA for treating relapsed multiple myeloma?
What is the primary function of Herceptin in cancer treatment?
What is the primary function of Herceptin in cancer treatment?
Which of the following drugs acts by blocking the androgen receptor?
Which of the following drugs acts by blocking the androgen receptor?
In the treatment of HER2-positive metastatic breast cancer, when is Herceptin considered effective?
In the treatment of HER2-positive metastatic breast cancer, when is Herceptin considered effective?
Which class of drugs do Leuprolide, Goserelin, Triptorelin, and Histrelin belong to?
Which class of drugs do Leuprolide, Goserelin, Triptorelin, and Histrelin belong to?
What type of antibody is Trastuzumab?
What type of antibody is Trastuzumab?
What is the mechanism of action of Trastuzumab Emtansine (Kadcyla)?
What is the mechanism of action of Trastuzumab Emtansine (Kadcyla)?
Which HER2 subdomain does Pertuzumab bind to?
Which HER2 subdomain does Pertuzumab bind to?
What is the main cause of limited activity of murine mAbs?
What is the main cause of limited activity of murine mAbs?
Which type of mAbs are created using the suffix '-ximab'?
Which type of mAbs are created using the suffix '-ximab'?
What is the main difference between Trastuzumab and Pertuzumab in terms of their mechanism of action?
What is the main difference between Trastuzumab and Pertuzumab in terms of their mechanism of action?
What is the goal of creating humanized and human mAbs?
What is the goal of creating humanized and human mAbs?
Which of the following mAbs is a human mAb?
Which of the following mAbs is a human mAb?
