Chemistry Fundamentals

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Questions and Answers

Which hydrocarbon formula indicates the presence of exactly one double bond within its carbon skeleton?

  • $C_3H_6$ (correct)
  • $C_3H_8$
  • $C_3H_4$
  • None of the above

Identify the functional group from the list that is generally considered nonpolar.

  • Carboxyl group
  • Methyl group (correct)
  • Sulfhydryl group
  • Hydroxyl group
  • None of the above

Which statement about atoms of various elements is NOT correct?

  • Atoms of different elements have different numbers of subatomic particles.
  • Neutrons and protons in the nucleus have approximately the same mass (about 1 Dalton).
  • An atom is the smallest unit of an element retaining the element's properties.
  • All atoms of a specific element have the same number of protons in their nuclei.
  • All of the above statements are correct. (correct)

Which of the following statements accurately describes a universal characteristic of all lipids?

<p>Lipids exhibit poor solubility in water. (B)</p> Signup and view all the answers

Given a set of molecules, which combination could be chemically linked to form a nucleotide?

<p>A pentose sugar, a nitrogenous base, and a phosphate group. (C)</p> Signup and view all the answers

The mass number of an element is best approximated by summing the number of which subatomic particles present in an atom of that element?

<p>protons and neutrons (A)</p> Signup and view all the answers

Consider Atom 1 (¹H) and Atom 2 (³H). Which statement accurately describes the relationship between them?

<p>They are isotopes. (D)</p> Signup and view all the answers

Which pair of molecules can undergo a dehydration reaction to form a peptide bond?

<p>Two amino acids (A)</p> Signup and view all the answers

Given that neon has an atomic number of 10, which statement about neon is NOT correct?

<p>It has an atomic mass of 10 Daltons. (B)</p> Signup and view all the answers

How is a triacylglycerol (fat) formed through dehydration reactions?

<p>One glycerol molecule and three fatty acid molecules combine. (C)</p> Signup and view all the answers

What structural feature is depicted when monomers are linked via 1-4 glycosidic linkages?

<p>The 1-4 linkage of the $\alpha$ glucose monomers of starch. (E)</p> Signup and view all the answers

Which of the following statements about liquid water is entirely correct?

<p>All of the above are correct (D)</p> Signup and view all the answers

DNA is a polymer comprised of _____ linked by _____ bonds, and in double-stranded DNA, they are also bonded to the opposite strand via _____ bonds.

<p>Nucleotides; covalently bonded; hydrogen-bonded (C)</p> Signup and view all the answers

What type of attraction occurs between the slight negative charge of one water molecule and the slight positive charge of another?

<p>a hydrogen bond (A)</p> Signup and view all the answers

To create 1 liter of a 2 M solution of calcium chloride (CaClâ‚‚), how should you proceed, given the following atomic masses: Ca = 40, Cl = 35?

<p>220 grams of CaClâ‚‚ then add water to make a total volume of 1 liter (A)</p> Signup and view all the answers

Consider Figure 4.7 (not provided). Which of the molecules listed contains an amine group?

<p>A (C)</p> Signup and view all the answers

Which type of bond is crucial for maintaining the specific three-dimensional shape of a polypeptide?

<p>Disulfide bond (D)</p> Signup and view all the answers

Which statement about protein structure is incorrect?

<p>The hydrogen atom that is responsible for α helices and β pleated sheets is covalently attached to the amino nitrogen. (D)</p> Signup and view all the answers

In individuals with celiac disease and a 'leaky gut,' defects in which structure of the intestinal epithelium are most likely to cause partially digested gluten to leak out?

<p>Tight junctions (C)</p> Signup and view all the answers

Which of the following microscopy techniques is least suitable for specifically localizing a small molecule like actin within a skin cell?

<p>Brightfield microscopy (C)</p> Signup and view all the answers

Gaucher disease, a genetic disorder, results from the deficiency of an enzyme that breaks down lipids. Where would fatty material NOT accumulate in someone with this disease?

<p>Heart (A)</p> Signup and view all the answers

Which component of the cell is NOT directly involved in the degradation process that is impaired in Gaucher disease?

<p>Ribosomes (D)</p> Signup and view all the answers

An experiment requires visualizing the detailed arrangement of smooth and rough endoplasmic reticulum (ER) within a cell. Which microscopy technique is most appropriate?

<p>Transmission electron microscopy (B)</p> Signup and view all the answers

Which of the following does NOT contribute to the folding and stability of a protein?

<p>Phosphodiester bonds (A)</p> Signup and view all the answers

In Gaucher disease, which organelle is most likely affected due to a deficiency in lipid breakdown?

<p>Lysosomes, due to a lack of necessary enzymes. (D)</p> Signup and view all the answers

Why do animal cells NOT require plasmodesmata, unlike plant cells?

<p>Animal cells do not have cell walls. (A)</p> Signup and view all the answers

In a vesicle transport experiment using microtubular tracks, vesicles, and ATP, researchers observed no movement. Which component was most likely missing?

<p>Motor proteins such as kinesin. (D)</p> Signup and view all the answers

Which of the following is closest to a micrometer ($\mu m$) in size?

<p>A typical bacterial cell. (A)</p> Signup and view all the answers

Which statement accurately compares chloroplasts and mitochondria?

<p>Chloroplasts and mitochondria have their own DNA and are capable of translating those genes into proteins using their own ribosomes. (D)</p> Signup and view all the answers

A pathologist needs to examine the internal structure of peroxisomes in liver cells. Which type of microscope is most suitable for this?

<p>Transmission electron microscope. (D)</p> Signup and view all the answers

How does the presence of cholesterol affect the fluidity of the animal cell membrane?

<p>Cholesterol decreases membrane fluidity at high temperatures but increases it at low temperatures. (A)</p> Signup and view all the answers

During receptor-mediated endocytosis, what primarily determines the specificity of the molecules that are transported into the cell?

<p>The affinity between receptors on the cell surface and specific ligands. (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic of phospholipids?

<p>Cannot engage in hydrophobic interactions. (A), Cannot associate with cholesterol. (C), Do not have polar heads. (D)</p> Signup and view all the answers

Radishes that have lost their crispness are placed in water and regain their turgor. What best describes this phenomenon?

<p>flaccid; into; increased (A)</p> Signup and view all the answers

As fish migrate to warmer waters, how do they adjust their membrane composition to maintain fluidity?

<p>phospholipids with unsaturated fatty acids (A)</p> Signup and view all the answers

Which statement accurately describes membrane transport processes?

<p>The sodium-potassium pump hydrolyzes ATP and results in a net positive charge outside the cell membrane. (C)</p> Signup and view all the answers

A new anticancer drug is large and polar, preventing its passage across the plasma membrane. Which mechanism could be used to transport the drug into cancer cells?

<p>receptor mediated endocytosis (C)</p> Signup and view all the answers

Which factor does NOT directly contribute to the fluidity of a cell membrane?

<p>The presence of integral proteins that span the membrane. (D)</p> Signup and view all the answers

Which of the following is NOT typically a direct role of integral membrane proteins?

<p>Producing energy in the form of ATP. (A)</p> Signup and view all the answers

Selective permeability is crucial for plasma membrane function. Which statement CORRECTLY describes its determinants?

<p>A and B are both correct. (E)</p> Signup and view all the answers

Complete the following sentence: Diffusion...

<p>Occurs due to the random movement of molecules. (C)</p> Signup and view all the answers

If an animal cell is observed to be shriveled, it is most likely in which type of environment?

<p>Hypertonicity (B)</p> Signup and view all the answers

What electrochemical force is created by differences in the distribution of positive and negative ions across a membrane?

<p>Membrane potential (D)</p> Signup and view all the answers

Which statement BEST describes the process of endocytosis?

<p>The process by which cells take in large molecules or particles by engulfing them. (C)</p> Signup and view all the answers

Which of the following statements BEST describes the structure of a membrane based on the fluid mosaic model?

<p>The membrane is composed of a fluid bilayer of phospholipids with embedded amphipathic proteins. (B)</p> Signup and view all the answers

Flashcards

Primary Structure

The specific sequence of amino acids linked together in a polypeptide chain.

Tertiary Structure

The unique, three-dimensional folded shape of a polypeptide, critical for its function.

Disulfide Bond

A strong covalent link between sulfur atoms of cysteine amino acids, stabilizing protein structure.

Peptide Bond

Covalent bond between the carboxyl carbon of one amino acid and the amino nitrogen of a second amino acid.

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Tight Junctions

They seal the space between cells. Defects cause 'leaky gut' by allowing molecules to pass between epithelial cells.

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Scanning Electron Microscopy

Uses electron beams to visualize fine surface details.

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Fluorescence Light Microscopy

Uses fluorescent markers to visualize specific molecules.

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Transmission Electron Microscopy

Uses electron beams to visualize internal cell structures.

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Atomic Differences

Atoms of different elements vary in their number of subatomic particles (protons, neutrons, and electrons).

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Mass Number

The sum of protons and neutrons in an atom's nucleus, approximating the atom's mass.

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Isotopes

Atoms of the same element with different numbers of neutrons.

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Inert Element

Having a full outer electron shell, making it stable and unreactive.

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Properties of Water

Water has a higher density as a liquid than as a solid (ice). It is also polar and has a high heat of vaporization.

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Hydrogen Bond

An attraction between the slight positive charge on a hydrogen atom and the slight negative charge of an electronegative atom (like oxygen or nitrogen).

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2M CaCl2 Solution

To make 1 liter of a 2M solution of CaCl2 you need 220 grams of CaCl2.

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Amine Group

A chemical group consisting of a nitrogen atom bonded to two hydrogen atoms (-NH2).

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Gaucher Disease Impact on Organelles

Lysosomes lack necessary enzymes for lipid breakdown, leading to accumulation of undigested lipids.

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Why Animal Cells Lack Plasmodesmata

Animal cells have direct contact between adjacent cells, facilitating communication without requiring channels through cell walls.

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Vesicular Transport Missing Component

Movement along microtubular tracks requires motor proteins like kinesin to facilitate vesicular transport.

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Size of a Bacterial Cell

A typical bacterial cell is around 1 micrometer in size.

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Chloroplast and Mitochondria DNA/Ribosomes

Chloroplasts and mitochondria have their own DNA and ribosomes, enabling them to synthesize proteins.

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Microscopy for Internal Structure Defects

Scanning electron microscopy is suited for detailed surface examination of a cell.

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Hydrocarbon with One Double Bond

C3H6 contains one double bond in its carbon skeleton.

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Nonpolar Functional Group

A methyl group (CH3) is nonpolar because of the equal sharing of electrons between carbon and hydrogen.

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Lipid Solubility

Lipids do not dissolve well in water due to their hydrophobic nature.

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Nucleotide Components

A nucleotide is formed by linking a phosphate group, a sugar, and a nitrogenous base.

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Peptide Bond Formation

Peptide bonds link amino acids via a dehydration reaction.

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Fat (Triacylglycerol) Formation

A fat (triacylglycerol) is formed from one glycerol molecule and three fatty acid molecules through dehydration reactions.

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Cellulose Structure

The figure shows the 1-4 linkage of β glucose monomers in cellulose.

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DNA Structure and Bonding

DNA is a polymer of nucleotides; these subunits are covalently bonded to each other through a phosphodiester bond. In double-stranded DNA, they are also hydrogen-bonded to nucleotides on the opposite strand.

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Phospholipid Polarity

Phospholipids have a polar (hydrophilic) head and nonpolar (hydrophobic) tails.

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Radish Crispness

Radish cells were limp (flaccid). Water entered, increasing turgor pressure.

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Fish Membrane Adaptation

Fish adapt by increasing unsaturated fatty acids. These maintain membrane fluidity at lower temperatures.

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Sodium-potassium pump

The sodium-potassium pump moves ions against their concentration gradients, creating a net positive charge outside the cell.

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CO2 Membrane Transport

Carbon dioxide (CO2) crosses the plasma membrane by simple diffusion down its concentration gradient.

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Drug Delivery to Cells

Receptor mediated endocytosis

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Endocytosis

The uptake of large molecules into a cell by inward folding of the plasma membrane to form a vesicle.

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Exocytosis

The fusion of vesicles with the plasma membrane to release their contents outside of the cell.

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Selective Permeability

A property of plasma membranes where they allow some substances to cross more easily than others.

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Diffusion

The random movement of molecules from an area of high concentration to an area of low concentration.

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Hypertonic Solution

A solution with a higher solute concentration compared to another solution.

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Membrane Potential

The voltage across a cell's plasma membrane due to the unequal distribution of ions.

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Electrochemical Gradient

Differences in the distribution of positive and negative ions across a membrane.

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Fluid mosaic model

A membrane is a fluid bilayer of phospholipids with embedded amphipathic proteins.

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Triacylglycerols (fats) and Lipid Bilayers

They lack a polar head group. They are primarily hydrophobic.

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Study Notes

Chapter 2

  • Atoms of different elements vary in the number of subatomic particles they contain.
  • Neutrons and protons located in the nucleus of an atom have nearly identical mass, approximately 1 Dalton each.
  • An atom forms the smallest unit of an element and retains the element's properties.
  • Atoms of an element contain the same number of protons in their nuclei.
  • An element's mass number is the sum of its protons and neutrons in an atom.
  • Isotopes are atoms with the same number of protons but different numbers of neutrons.
  • Neon's atomic number is 10, therefore it has 10 protons.

Chapter 3

  • Liquid water is denser than ice.
  • Water is polar.
  • Water requires a high heat of vaporization compared to other substances.
  • A hydrogen bond forms between the slight negative charge of one water molecule and the slight positive charge of another.

Chapter 4

  • To create 1 liter of a 2 M calcium chloride (CaCl2) solution, place 220 grams of CaCl2 in a container and add water to bring the total volume to 1 liter.
  • Molecule E contains an amine group (check structure in provided material for reference).
  • C3H6 possesses one double bond in its carbon backbone by definition of the chemical formula (check structure in provided material for reference).
  • Methyl group is not polar

Chapter 5

  • All lipids do not dissolve well in water, and tend to assemble into bilayers when mixed with aqueous solutions.
  • Molecules 11, 12, and 13 can combine to make a nucleotide (check structure in provided material for reference).
  • Molecules 3 and 7 can join together by a peptide bond because of a dehydration reaction (check structure in provided material for reference).
  • A fat (triacylglycerol) results from a dehydration reaction between one molecule of 9 and three molecules of 10.(check structure in provided material for reference).
  • The structure depicted in Figure 5.7 shows the double helical structure of a DNA molecule.
  • DNA, a polymer of nucleotides, connects via phosphodiester bonds; in double-stranded DNA, the strands also link covalently to nucleotides on the opposite strand.
  • Saturated fat has the highest concentration of C-H bonds.

Chapter 6

  • Tertiary protein structure features a unique 3D shape within a fully folded polypeptide.
  • A disulfide bond between amino acids maintains a polypeptide's three-dimensional shape.
  • A false statement regarding protein structure: In properly folded cytoplasmic proteins, amino acids with hydrophilic R groups are typically tucked inside the protein.
  • Celiac disease results from defects in the tight junctions of the intestinal epithelium.
  • Brightfield microscopy is not well suited to specifically localize a small molecule like actin, therefore, the answer is B.
  • In Gaucher disease, lysosomes likely lack enzymes for lipid breakdown.
  • Animal cells do not need plasmodesmata because they lack cell walls.
  • Vesicular transport was missing motor proteins such as kinesin.
  • A typical bacterial cell is closest to a micrometer in size.
  • Both chloroplasts and mitochondria contain their own DNA and can translate it into proteins using their own ribosomes.
  • A pathologist would likely use a TEM, transmission electron microscope, or TEM, to examine the internal structure defect within peroxisomes.

Chapter 7

  • The existence of integral membrane proteins spanning the membrane, is not a factor contributing to fluidity of the cell membrane
  • Integral membrane proteins transport molecules across the cell membrane, act as signal transduction receptors, facilitate cell-cell recognition.
  • Selective permeability relates to both which molecules can transit the lipid bilayer unaided and transport proteins assisting molecule movement across a lipid bilayer.
  • Diffusion occurs due to random particle motion.
  • Animal cells that appear shriveled may be suffering from hypertonicity.
  • An electrochemical gradient is created by uneven distribution of positive and negative ions across a membrane.
  • Endocytosis describes the process by which cells engulf large molecules or particles.
  • In the fluid mosaic model, a membrane features a fluid bilayer of phospholipids with embedded amphipathic proteins.
  • Triacylglycerols cannot form lipid bilayers because they lack polar heads.
  • Radish cells likely became flaccid, water moved into the cells, and therefore turgor pressure increased due to the change.
  • To adapt to warmer waters, fish must increase the proportion of phospholipids with unsaturated fatty acids in their plasma membranes.
  • The sodium-potassium pump hydrolyzes ATP, yielding a net positive charge outside the cell membrane.
  • Carbon dioxide crosses the plasma membrane via simple diffusion.
  • Anticancer drugs that are large and contain many polar groups require receptor-mediated endocytosis to enter cancer cells.

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