Chemistry Equilibrium and Acids Quiz
91 Questions
2 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

If the equilibrium constant (K) for a reaction is very large, which of the following is true?

  • The reaction is very slow.
  • The reaction favors the formation of products. (correct)
  • The reaction favors the formation of reactants.
  • The reaction is at equilibrium.
  • Which of the following is NOT considered in the equilibrium constant expression?

  • Concentration of products
  • Concentration of pure solids (correct)
  • Concentration of pure liquids
  • Concentration of reactants
  • What happens to the equilibrium constant (K) when a reaction is reversed?

  • K becomes the reciprocal of the original K. (correct)
  • K becomes halved.
  • K becomes doubled.
  • K remains the same.
  • According to the Brønsted definition, which of the following is a base?

    <p>A species that accepts a hydrogen ion (H+). (A)</p> Signup and view all the answers

    What is a conjugate acid-base pair?

    <p>Two species that differ only by the presence of a hydrogen ion (H+). (D)</p> Signup and view all the answers

    What is an amphiprotic species?

    <p>A species that can act as both an acid and a base. (D)</p> Signup and view all the answers

    Which of the following is an example of a strong acid?

    <p>Hydrochloric acid (HCl) (C)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of a strong base?

    <p>It is a weak electrolyte. (D)</p> Signup and view all the answers

    What is the relationship between the solubility of a solute and temperature if the enthalpy of solution (ΔHsoln) is negative?

    <p>Solubility decreases with increasing temperature (D)</p> Signup and view all the answers

    According to Le Châtelier's Principle, what will happen to the equilibrium of a reaction if more reactants are added?

    <p>The equilibrium will shift to the right, favoring the products (D)</p> Signup and view all the answers

    How does pressure affect the solubility of a gaseous solute in a liquid solvent?

    <p>Pressure increases the solubility of a gaseous solute (B)</p> Signup and view all the answers

    What is the quantitative relationship between pressure and solubility as described by Henry's Law?

    <p>Solubility is directly proportional to pressure (A)</p> Signup and view all the answers

    What is the primary application of Henry's Law in the field of anesthesia?

    <p>Calculating the amount of dissolved oxygen and carbon dioxide in the blood (A)</p> Signup and view all the answers

    What is the process called when the concentration of a volatile anesthetic in a patient is significantly increased to speed up uptake?

    <p>Overpressurization (C)</p> Signup and view all the answers

    If the partial pressure of oxygen (PaO2) in arterial blood is 300 mmHg, how much oxygen is dissolved in 100 ml of blood?

    <p>0.9 ml O2 (A)</p> Signup and view all the answers

    How much does the dissolved oxygen in the blood increase when the partial pressure of oxygen (PaO2) increases from 100 mmHg to 500 mmHg?

    <p>1.2 ml O2/100 ml blood (D)</p> Signup and view all the answers

    What is the primary characteristic of isotonic solutions?

    <p>They contain equal concentrations of particles. (B)</p> Signup and view all the answers

    What role does oncotic pressure play in the vascular system?

    <p>It balances hydrostatic pressure pushing water into capillaries. (D)</p> Signup and view all the answers

    What is the effect of increasing solute concentration on osmotic pressure?

    <p>It increases osmotic pressure. (B)</p> Signup and view all the answers

    Why is nitrous oxide contraindicated in patients with pneumothorax?

    <p>It can cause mucosal damage when expanding. (A)</p> Signup and view all the answers

    What is the primary factor that drives the process of diffusion?

    <p>Entropy. (B)</p> Signup and view all the answers

    Which substance does not penetrate the capillary wall but provides osmotic pressure?

    <p>Albumin. (D)</p> Signup and view all the answers

    What is the primary function of a semipermeable membrane in osmosis?

    <p>It is permeable to water only. (C)</p> Signup and view all the answers

    In the context of capillary dynamics, what happens to fluid upon the delivery of colloids?

    <p>Fluid is retained within the vascular system. (C)</p> Signup and view all the answers

    What is the primary function of a pH buffer solution?

    <p>To resist changes in pH (C)</p> Signup and view all the answers

    What is the result of adding a strong base to a buffered solution?

    <p>The weak acid in the buffer reacts to form water and a weak base (C)</p> Signup and view all the answers

    What happens to the unionized fraction of a weak base when placed in an environment with pH greater than its pKa?

    <p>It predominates (C)</p> Signup and view all the answers

    Which molecules primarily consist of buffers in the human body?

    <p>Bicarbonate, phosphate, and proteins (D)</p> Signup and view all the answers

    How does blood pH affect enzyme activity?

    <p>It can alter enzyme activity and metabolic functions (B)</p> Signup and view all the answers

    What kind of reaction occurs when a strong acid is added to a buffered solution?

    <p>The weak base reacts with H+ ions to form a weak acid (B)</p> Signup and view all the answers

    What role does the respiratory system play in pH balance?

    <p>It eliminates carbon dioxide to alter blood pH (A)</p> Signup and view all the answers

    If the pKa of a weak acid is greater than the pH of the solution, what fraction predominates?

    <p>Ionized fraction (D)</p> Signup and view all the answers

    What is the primary function of metabolism in cells?

    <p>To allow cells to continue living by obtaining chemical energy from foods (C)</p> Signup and view all the answers

    Which type of reaction is dehydration synthesis?

    <p>It is a process where energy is absorbed to form a covalent bond. (A)</p> Signup and view all the answers

    Which of the following statements about ATP is true?

    <p>The energy released from each high-energy bond per mole of ATP is approximately 12,000 calories. (B)</p> Signup and view all the answers

    What role does insulin play in glucose transport?

    <p>It enables active co-transport or facilitated diffusion of glucose using carrier proteins. (C)</p> Signup and view all the answers

    What is the common pathway for the transport of carbohydrates into cells?

    <p>Glucose (D)</p> Signup and view all the answers

    During the process of phosphorylation, what compound is formed when glucose enters the cell?

    <p>Glucose-6-phosphate (D)</p> Signup and view all the answers

    What differentiates aerobic metabolism from anaerobic metabolism in terms of ATP production?

    <p>Aerobic metabolism produces much more ATP than anaerobic metabolism. (A)</p> Signup and view all the answers

    Which of the following best describes catabolism?

    <p>The breakdown of complex molecules, releasing energy. (A)</p> Signup and view all the answers

    What describes the behavior of weak acids when dissolved in water?

    <p>They establish a dynamic equilibrium between the molecular and ionized forms. (C)</p> Signup and view all the answers

    How do polyprotic acids, like diprotic acids, behave in terms of donating hydrogen ions?

    <p>They can behave as an acid twice. (C)</p> Signup and view all the answers

    What is the conjugate base of a strong acid typically characterized by?

    <p>No base strength. (C)</p> Signup and view all the answers

    In an acid-base reaction, what happens to the acid and base?

    <p>The acid converts into its conjugate base. (B)</p> Signup and view all the answers

    Which statement about weak bases is correct?

    <p>They establish a dynamic equilibrium in their molecular and ionized forms. (D)</p> Signup and view all the answers

    When comparing the strength of conjugate acid-base pairs, which relationship is accurate?

    <p>A strong acid has a weak conjugate base. (D)</p> Signup and view all the answers

    Which of the following is true regarding the charges of acids and bases in a reaction?

    <p>The base almost always has a lower (more negative) charge than the acid. (A)</p> Signup and view all the answers

    Which characteristic does not apply to polyprotic acids?

    <p>The number of acidic protons determines the total number of hydrogens. (C)</p> Signup and view all the answers

    Which of the following factors can affect chemical equilibrium?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following factors can affect the position of equilibrium in a chemical reaction?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following statements correctly describes the equilibrium constant (K) when it decreases?

    <p>The reaction favors the starting materials. (A)</p> Signup and view all the answers

    What is the relationship between pH and pOH in an aqueous solution at 25°C?

    <p>pH + pOH = 14.00 (C)</p> Signup and view all the answers

    What is the effect of dissolving carbon dioxide in water on the pH of the solution?

    <p>The pH decreases. (D)</p> Signup and view all the answers

    Which of the following is NOT true about the pH scale?

    <p>A pH of 14 indicates the most acidic solution. (C)</p> Signup and view all the answers

    What is the primary reason for the slight alteration in hemoglobin structure in cellular tissue with high carbon dioxide concentration?

    <p>To facilitate the release of oxygen from hemoglobin. (A)</p> Signup and view all the answers

    What is the relationship between pKa and pKb for a conjugate acid-base pair?

    <p>pKa + pKb = 14.00 (D)</p> Signup and view all the answers

    What is the primary role of nonmetal oxides in the context of acidity?

    <p>They form acidic solutions when dissolved in water. (A)</p> Signup and view all the answers

    Which of the following statements accurately describes the behavior of carbonic acid (H2CO3) in an aqueous solution?

    <p>Carbonic acid is a weak acid that partially dissociates in water. (C)</p> Signup and view all the answers

    How does the buildup of carbon dioxide in the blood contribute to acidosis?

    <p>Carbon dioxide reacts with water to form carbonic acid, increasing hydrogen ion concentration. (A)</p> Signup and view all the answers

    Which type of phospholipid is a component of myelin sheaths surrounding nerve cells?

    <p>Sphingomyelins (B)</p> Signup and view all the answers

    What is a primary consequence of atherosclerosis in large arteries?

    <p>Deposition of fatty lesions (B)</p> Signup and view all the answers

    Which substance is essential for the synthesis of cholesterol and is inhibited by statins?

    <p>HMG-CoA reductase (D)</p> Signup and view all the answers

    Which factor is NOT associated with leading to atherosclerosis?

    <p>High fiber diet (D)</p> Signup and view all the answers

    Which of the following hormones can be synthesized from cholesterol?

    <p>Cortisol (B)</p> Signup and view all the answers

    What is a significant feature of regulatory proteins like G Protein Coupled Receptors?

    <p>They transmit signals across the cell membrane. (B)</p> Signup and view all the answers

    Which of the following dietary changes is considered most important in the prevention of atherosclerosis?

    <p>Maintain a low-fat diet (D)</p> Signup and view all the answers

    What is the process by which fatty acids are converted to Acetyl-CoA?

    <p>Beta-oxidation (A)</p> Signup and view all the answers

    What percentage of body solids are made up of proteins?

    <p>75% (D)</p> Signup and view all the answers

    What are ketone bodies primarily produced from during periods of carbohydrate scarcity?

    <p>Fat oxidation (B)</p> Signup and view all the answers

    What role does lipoprotein lipase play in the metabolism of triglycerides?

    <p>Hydrolysis of triglycerides (D)</p> Signup and view all the answers

    What happens to triglycerides in fat cells when there is an increased need for lipids in the body?

    <p>They are hydrolyzed to fatty acids and glycerol (D)</p> Signup and view all the answers

    Which hormone is responsible for activating triglyceride lipase to increase free fatty acids in the blood?

    <p>Epinephrine (C)</p> Signup and view all the answers

    What is the primary storage form of fat in adipose tissue?

    <p>Triglycerides (C)</p> Signup and view all the answers

    What percentage of calories from fats is typical in the American diet?

    <p>30-50% (B)</p> Signup and view all the answers

    What metabolic pathway does glycerol enter after being converted from triglycerides?

    <p>Glycolytic pathway (B)</p> Signup and view all the answers

    What is the primary role of albumin in the bloodstream?

    <p>Regulating colloid osmotic pressure (C)</p> Signup and view all the answers

    Which type of amino acids must be obtained from the diet due to the body's inability to synthesize them?

    <p>Essential amino acids (B)</p> Signup and view all the answers

    What occurs during the process of deamination?

    <p>Removal of an amino group from an amino acid (B)</p> Signup and view all the answers

    What happens to amino acids when their concentrations exceed the renal threshold for reabsorption?

    <p>They are excreted in urine (A)</p> Signup and view all the answers

    What is the consequence of consuming less than 20-30 g of protein per day?

    <p>Starvation and muscle wasting (D)</p> Signup and view all the answers

    Which enzymes are primarily responsible for the deamination of amino acids?

    <p>Aminotransferases (B)</p> Signup and view all the answers

    What is ketogenesis?

    <p>Conversion of amino acids into keto acids or fatty acids (C)</p> Signup and view all the answers

    What stimulates the transport of amino acids into cells?

    <p>Insulin (B)</p> Signup and view all the answers

    What is the primary function of glycogenolysis?

    <p>Break down glycogen to release glucose (A)</p> Signup and view all the answers

    How many ATP molecules are produced during glycolysis from one mole of glucose?

    <p>2 (C)</p> Signup and view all the answers

    Which compound is formed when Acetyl-CoA combines with oxaloacetic acid in the Citric Acid Cycle?

    <p>Citric acid (B)</p> Signup and view all the answers

    What occurs during the process of oxidative phosphorylation?

    <p>Electrons are transferred through the Electron Transport Chain (D)</p> Signup and view all the answers

    In glycolysis, glucose is split into how many molecules of pyruvic acid?

    <p>2 (A)</p> Signup and view all the answers

    What is the efficiency of ATP formation per mole of glucose during glycolysis?

    <p>43% (C)</p> Signup and view all the answers

    What is the net reaction produced in the Citric Acid Cycle per molecule of glucose?

    <p>2 Acetyl-CoA + 6 H2O → 4 CO2 + 16 H + 2 CoA + 2 ATP (C)</p> Signup and view all the answers

    What is the approximate number of calories released from one gram-mole of glucose during its oxidation?

    <p>686,000 calories (B)</p> Signup and view all the answers

    Flashcards

    Metabolism

    The chemical processes that allow cells to live by converting food energy into usable forms.

    Anabolism

    A metabolic process that involves the synthesis of complex molecules from simpler ones, requiring energy input.

    Catabolism

    A metabolic process that involves the breakdown of complex molecules into simpler ones, releasing energy.

    Dehydration Synthesis

    An anabolic reaction where two monomers bind together, releasing water and storing energy.

    Signup and view all the flashcards

    Hydrolysis

    A catabolic reaction in which polymers are broken down into monomers by the addition of water, releasing energy.

    Signup and view all the flashcards

    ATP

    Adenosine Triphosphate; the energy currency of the cell, used in many biochemical reactions.

    Signup and view all the flashcards

    Glucose Transport

    The process by which glucose moves into cells, facilitated by insulin and requires a carrier protein.

    Signup and view all the flashcards

    Phosphorylation

    The process of adding a phosphate to glucose upon entry into the cell, forming glucose-6-phosphate for energy use or storage.

    Signup and view all the flashcards

    ΔHsoln

    The change in enthalpy during a solution process. Negative indicates exothermic, positive indicates endothermic.

    Signup and view all the flashcards

    Le Châtelier’s Principle

    A principle stating that if a system in equilibrium is disturbed, it will shift to counteract the change.

    Signup and view all the flashcards

    Effect of Pressure on Gas Solubility

    Gas solubility in a liquid increases with increasing pressure, especially for gaseous solutes.

    Signup and view all the flashcards

    Henry's Law

    At constant temperature, gas solubility is proportional to its partial pressure above the liquid.

    Signup and view all the flashcards

    Overpressurizing

    Increasing the concentration of a volatile anesthetic to enhance its uptake in the blood.

    Signup and view all the flashcards

    Dissolved O2 Calculation

    The amount of O2 in blood is calculated by multiplying partial pressure by 0.003 ml/100 ml blood/mmHg.

    Signup and view all the flashcards

    Total O2 Dissolved Increase

    To find the increase in dissolved O2, calculate the difference based on PaO2 levels.

    Signup and view all the flashcards

    Gas Compressibility

    Gases are more compressible than solids or liquids, affecting their solubility under pressure.

    Signup and view all the flashcards

    Tonicity

    The relative concentration of solutes in solutions.

    Signup and view all the flashcards

    Isotonic Solutions

    Two solutions with equal concentrations of particles.

    Signup and view all the flashcards

    Osmosis

    Movement of water across a semipermeable membrane to equalize concentration.

    Signup and view all the flashcards

    Osmotic Pressure

    The force needed to stop osmosis from occurring, related to solute concentration.

    Signup and view all the flashcards

    Oncotic Pressure

    Osmotic pressure exerted by plasma proteins in capillaries, important for fluid balance.

    Signup and view all the flashcards

    Colligative Properties

    Properties that depend on the number of solute particles in a solution, affecting osmotic pressure.

    Signup and view all the flashcards

    Diffusion

    The passive movement of particles from an area of higher concentration to lower concentration.

    Signup and view all the flashcards

    Apneic Oxygenation

    Oxygenation during apnea, utilizes diffusion to maintain oxygen levels.

    Signup and view all the flashcards

    Equilibrium Constant (K)

    Numerical description of balance in a reaction; indicates favorability of products or reactants.

    Signup and view all the flashcards

    Kforward and Kreverse

    Kforward is the reciprocal of Kreverse when a reaction is reversed.

    Signup and view all the flashcards

    Arrhenius Acid Definition

    An acid increases hydronium ion (H3O+) concentration in solution.

    Signup and view all the flashcards

    Arrhenius Base Definition

    A base increases hydroxide ion (OH-) concentration in solution.

    Signup and view all the flashcards

    Brønsted Acid

    Species that donates a hydrogen ion (H+) to a base.

    Signup and view all the flashcards

    Brønsted Base

    Species that accepts a hydrogen ion (H+) from an acid.

    Signup and view all the flashcards

    Conjugate Acid-Base Pair

    The conjugate acid has a charge one greater than its conjugate base.

    Signup and view all the flashcards

    Strong Acids

    Acids that are almost 100% ionized in water, converting all into products.

    Signup and view all the flashcards

    Weak Acids

    Acids that partially dissociate in water and establish equilibrium between molecular and ionized forms.

    Signup and view all the flashcards

    Weak Bases

    Bases that partially accept hydrogen ions and do not completely ionize in water, creating equilibrium between molecular and ionized forms.

    Signup and view all the flashcards

    Polyprotic Acids

    Acids that can donate more than one hydrogen ion; diprotic has two, triprotic has three.

    Signup and view all the flashcards

    Acid-Base Reactions

    Reactions that involve the transfer of hydrogen ions from acids to bases.

    Signup and view all the flashcards

    Dynamic Equilibrium

    A state where the forward and reverse reactions occur at the same rate, leading to stable concentrations.

    Signup and view all the flashcards

    Diprotic Acid

    An acid capable of donating two protons during a reaction.

    Signup and view all the flashcards

    Triprotic Acid

    An acid capable of donating three protons in a reaction.

    Signup and view all the flashcards

    pH Buffer

    A solution that resists changes in pH, containing a weak acid and its conjugate base.

    Signup and view all the flashcards

    Weak Acid and Conjugate Base

    A weak acid (HA) reacts with a strong base (OH−) to maintain pH by creating water and a weak base (A−).

    Signup and view all the flashcards

    Henderson–Hasselbalch Equation

    A formula used to estimate the pH of a buffer system based on pKa and concentrations of acid and base.

    Signup and view all the flashcards

    Ionized vs Unionized

    Ionization depends on pH relative to pKa; weak base becomes ionized if pH < pKa, and weak acid if pH > pKa.

    Signup and view all the flashcards

    Respiratory System and pH Balance

    The respiratory system helps maintain blood pH by managing CO2 levels, working with kidneys and buffers.

    Signup and view all the flashcards

    Role of Buffers

    Buffers like bicarbonate, phosphate, and proteins keep pH within the physiological range.

    Signup and view all the flashcards

    Hydrogen Ion Interaction

    Hydrogen ions alter the structure of proteins, affecting their behavior and enzymatic activity.

    Signup and view all the flashcards

    Acid-Base Disturbances

    Observed through PaCO2 and HCO3 levels to determine if changes are respiratory or metabolic.

    Signup and view all the flashcards

    Study Notes

    Chemical Reactions and Metabolism

    • Metabolism describes the chemical processes that keep cells alive.
    • Anabolism is the synthesis of molecules, whereas catabolism is the breakdown of molecules.
    • Energy production involves oxidation of proteins, carbohydrates, and fats to make ATP.
    • Energy usage involves processes like active transport, muscle contraction, synthesis of molecules, and cell growth.
    • Chemical energy in food must be released slowly to fuel cellular processes like membrane pumps, protein synthesis, and muscle contractions.

    Carbohydrate Metabolism and Formation of ATP

    • Glucose (C6H12O6) is the most important carbohydrate for energy transport into cells.
    • After absorption, most fructose and galactose convert to glucose in the liver.
    • Glucose enters the cell through facilitated diffusion with a carrier protein via cotransport or facilitated diffusion.
    • Phosphorylation converts glucose to glucose-6-phosphate (immediately used or stored as glycogen).
    • Glycogenesis forms glycogen (a starch).
    • Glycogenolysis breaks glycogen into glucose.
    • Glycolysis splits glucose into two pyruvate molecules, producing 2 ATP + 4 H.
    • Efficiency of ATP formation during glycolysis is 43%.
    • Pyruvate molecules combined with Coenzyme A to form Acetyl-CoA.
    • Krebs Cycle, also known as Citric Acid Cycle, starts with Acetyl CoA combines with oxaloacetic acid to form citric acid.
    • Krebs Cycle releases 24 hydrogen atoms per molecule of glucose, forming up to 24 ATP later.
    • Oxidative phosphorylation, consisting of Electron Transport Chain & chemiosmosis, is oxygen-dependent, generating 34 more ATPs.
    • Aerobic metabolism yields much more ATP than anaerobic.
    • Total ATP production from glucose: 38 ATP.

    Energy Foods

    • Fats, carbohydrates, and proteins can be oxidized by cells to release large amounts of energy.
    • Phosphate bonds in ATP have high energy content.

    Coupled Reactions

    • Chemical energy in foods must be released slowly.
    • Energy release is coupled with cellular processes like membrane pumps and protein synthesis.

    ATP - Adenosine Triphosphate

    • ATP transfers energy between coupled reactions.
    • Present throughout the cell, storing energy in high-energy bonds.
    • Each high-energy bond in a mole of ATP stores 12,000 calories.

    Glucose (Dextrose)

    • After absorption from the GI tract, fructose and galactose are converted to glucose in the liver.
    • Glucose is the final common pathway for carbohydrate transport into cells.

    Transport of Glucose Through Cell Membrane

    • Active co-transport or facilitated diffusion with a carrier protein is necessary.
    • Insulin facilitates this process.

    Phosphorylation

    • Immediately upon entering cells, glucose combines with a phosphate radical to form glucose-6-phosphate.
    • Glucose-6-phosphate is used immediately for cellular energy or stored as glycogen.

    Glycogenesis

    • Formation of glycogen, a starch.

    Glycogenolysis

    • Breakdown of glycogen to glucose in the liver.
    • Makes glucose available, using phosphorylation via phosphorylase.
    • Hormones (epinephrine and glucagon) activate phosphorylase.

    Release of Energy from Glucose

    • Glycolysis, the citric acid cycle, and the electron transport chain release energy from glucose.

    Glycolytic Pathway

    • One gram-mole of glucose releases 686,000 calories, and only 12,000 calories are needed to form one gram-mole of ATP.
    • Enzymes oxidize glucose in small steps, maximizing energy capture as ATP.
    • Energy is released in packets, yielding 38 ATP per mole of glucose.

    Glycolysis

    • The most important process for releasing energy from glucose
    • Involves 10 steps
    • Ends with the formation of 2 pyruvic acid molecules + 2 ATP + 4 H.
    • Happens in cytoplasm.
    • 2 Pyruvic acid molecules combine with Coenzyme A to form Acetyl-CoA.

    Citric Acid Cycle (Krebs Cycle)

    • Occurs in the matrix of mitochondria.
    • Acetyl CoA combines with oxaloacetic acid to form citric acid.
    • The cycle begins and ends with oxaloacetic acid production.
    • Releases 24 hydrogen atoms per glucose molecule, leading to ATP generation.

    Citric Acid Cycle (Krebs Cycle) (Hydrogen atoms)

    • 20 hydrogen atoms combine with NAD+ via dehydrogenase.
    • Carbon dioxide and hydrogen atoms are released during the next stages.
    • 2 molecules of ATP are produced.

    Net Reaction per Molecule of Glucose in Citric Acid Cycle

    • The reaction can be summarized as: 2 Acetyl-CoA + 6 H2O + 2 ADP → 4 CO2 + 16 H+ + 2 CoA + 2 ATP.

    Oxidative Phosphorylation

    • Oxygen is needed.
    • NADH splits into NAD+, H+, and e- by hydrogen oxidation.
    • Electrons enter the electron transport chain.
    • Energy released is captured as a proton gradient to create ATP.
    • The entire process is called chemiosmosis.

    Summary of ATP Formation

    • Glycolysis yields 4 ATP (2 used), and 2 ATP from the Krebs Cycle, 34 ATP from the Electron Transport Chain.
    • In total 38 ATP from one glucose molecule.
    • Glucose oxidation is approximately 66% efficient (in comparison to total energy released).
    • Feedback controls start or stop ATP formation.

    Anaerobic Glycolysis

    • Results from a lack of oxygen.
    • Pyruvic acid + NADH + H+ → lactic acid.
    • Measuring lactic acid in the OR reflects cell oxygen usage.
    • When oxygen is available, lactic acid re-enters the glucose pathway to produce energy.

    Storage of Glucose

    • Glycogen stores fill up first, followed by fat storage.

    Gluconeogenesis

    • When glucose isn't available, it's synthesized from fats (glycerol) and proteins (amino acids).
    • Low blood glucose triggers the release of cortisol.
    • Cortisol promotes protein breakdown to amino acids, suitable for liver glucose conversion.
    • This is a catabolic process.

    Lipid Metabolism

    • Lipids are cellular fuels, with high energy content.
    • Lipids are the most efficient form of cellular energy storage.
    • Major lipids include triglycerides, phospholipids, and cholesterol.

    Fatty Acids

    • Fatty acids are simple, long-chain hydrocarbon carboxylic acids.
    • They contain the carboxyl group (-COOH).
    • Examples of fatty acids include Palmitic acid (CH3(CH2)14COOH).

    Triglycerides

    • Triglycerides are three long-chain fatty acid molecules attached to a glycerol molecule.
    • Glycerol is a triple alcohol (OH).
    • Tristearin is an example.

    Absorption of Fats

    • Dietary triglycerides are broken down into monoglycerides and fatty acids in the intestines.
    • These are repackaged as chylomicrons, absorbed into the lymphatic system.
    • Plasma becomes turbid following a high-fat meal.

    Uptake Into Cells

    • Lipoprotein lipase within capillary endothelium (liver cells) hydrolyzes triglycerides into fatty acids and glycerol.
    • Fatty acids diffuse into cells.
    • Once inside, fatty acids are resynthesized into triglycerides for storage.

    Transport Through Body

    • Fat cells hydrolyze triglycerides into fatty acids and glycerol when lipids are needed.
    • These components enter the bloodstream and combine with albumin to form free fatty acids.

    Fat Deposits

    • Adipose tissue is called fat deposits or simple tissue fat.
    • Fats are also stored in the liver (potentially leading to non-alcoholic steatohepatitis (NASH)).
    • Adipose tissue fat cells are typically 80–95% triglycerides.
    • Fat deposits are responsive to hormonal and other factors.

    Use of Triglycerides for Energy

    • Up to 50% of the calories in the typical American diet come from fats.
    • Triglycerides are hydrolyzed into fatty acids and glycerol.
    • Glycerol is transformed into glycerol-3-phosphate and enters the glycolytic pathway for glucose utilization.
    • Fatty acids enter mitochondria for oxidation.

    Beta-Oxidation

    • Fatty acids are converted to acetyl-CoA through beta-oxidation, a multi-step process.
    • Acetyl-CoA enters the citric acid cycle in carbohydrate metabolism.
    • Beta-oxidation of stearic acid produces 148 molecules of ATP (after initial 2 ATP use, leaving a 146 net gain).

    Ketosis

    • Fats are oxidized to fuel the body when carbohydrates are unavailable (like in the Atkins diet).
    • High concentrations of B-hydroxybutyric acid, acetoacetic acid, and acetone form ketone bodies.
    • Causes include starvation, diabetes mellitus, and high-fat, low-carb diets.

    Regulation of Fat Utilization

    • Epinephrine and norepinephrine activate triglyceride lipase, increasing free fatty acid production.
    • Corticotropin and glucocorticoid release (from the anterior pituitary and adrenal cortex) increase fatty acid use.
    • Insulin release decreases.

    Phospholipids

    • Phospholipids contain a fatty acid molecule, phosphoric acid radical, and a nitrogenous base.
    • Three types are lecithins, cephalins, and sphingomyelins.

    Uses of Phospholipids

    • Essential components of cell membranes.
    • Found in lipoproteins.
    • Involved in clotting (thromboplastin).
    • Constituents of myelin sheaths in nerve cells.
    • Act as phosphate radical donors.

    Uses of Cholesterol

    • Forms cholic acid (bile) for fat digestion.
    • Converted into adrenocortical hormones like cortisol.
    • Precursor for sex hormones (estrogen, progesterone, and testosterone).
    • Forms a waterproof layer in the skin (corneum).

    Atherosclerosis

    • A disease characterized by fatty lesions (atheromatous plaques) accumulating in large arteries.
    • Arterosclerosis leads to vessel thickening and stiffening.
    • Plaques are mainly composed of cholesterol.
    • Connective tissue within plaques causes vessel wall stiffening (sclerotic).
    • Plaque can occlude vessels, causing rupture.

    Factors that Lead to Atherosclerosis

    • Physical inactivity and obesity.
    • Familial history.
    • Diabetes mellitus.
    • High blood pressure (hypertension).
    • High blood lipids (hyperlipidemia).
    • Smoking.

    Prevention of Atherosclerosis

    • Consume a low-fat diet (most important).
    • Do not smoke.
    • Exercise regularly.
    • Manage blood pressure.
    • Manage blood glucose levels.
    • Include oat bran in diet to bind bile acids in the gut.
    • Statins inhibit HGM-CoA reductase and reduce cholesterol synthesis.

    Protein Metabolism

    • Proteins, comprising 3/4th of body solids, are made from 20 amino acids linked by peptide bonds and hydrogen bonds.
    • Structural components, enzymes, oxygen transport, nucleoproteins, muscle contraction, and cellular functions are protein-dependent.

    Regulatory Protein

    • Regulatory proteins transmit messages from a chemical signal to other parts of cells.
    • G protein-coupled receptors transmit messages through cell membranes.
    • Ligands bind to receptors, activating G protein-linked intracellular events.
    • These messages lead to communication between cells.

    Transport of Amino Acids

    • Proteins are digested into amino acids in the gastrointestinal tract.
    • Protein digestion/absorption takes 2-3 hours.
    • Active transport and facilitated diffusion move amino acids into cells.
    • Excess amino acids exceed renal threshold and excretion occurs in urine.

    Storage of Amino Acids

    • Amino acids immediately enter cells after digestion, becoming new proteins.
    • Low blood amino acid levels trigger their transport out of the cells.

    Major Plasma Proteins

    • Albumin - colloid osmotic pressure
    • Globulins - enzymes, immune system
    • Fibrinogen - coagulation

    Dietary Amino Acids

    • 10 essential amino acids must be ingested, as the body cannot synthesize them.
    • 10 other (nonessential) amino acids can be synthesized by the body, but adequate amounts are needed for protein synthesis.

    Use of Proteins for Energy

    • Protein breakdown, or deamination, occurs in the liver.
    • Removal of the amino group (NH2) from amino acids.
    • Aminotransferases are enzymes responsible for deamination.

    Urea

    • Ammonia, a neurotoxin from deamination, is converted to urea in the liver for removal from the blood.
    • Urea is excreted by the kidneys.

    Oxidation of Deaminated Amino Acids

    • Deaminated keto acids are degraded into substances that can enter the citric acid cycle.
    • These substances are oxidized to produce ATP.
    • This conversion to keto acids or fatty acids is called ketogenesis.

    Obligatory Degradation of Proteins

    • 20-30 g of protein is degraded to amino acids and oxidized daily.
    • Protein intake less than that level leads to starvation. - Carbohydrates are protein sparers.

    Hormonal Regulation of Protein Metabolism

    • Growth hormone promotes amino acid transport into cells for protein synthesis.
    • Insulin increases amino acid transport into cells.
    • Glucocorticoids increase the breakdown of extrahepatic proteins.
    • Testosterone promotes protein deposition in muscle tissue.
    • Thyroxine (T4) increases the rate of metabolism.

    Aqueous Solutions & Concentrations: Solubility, Diffusion, and Osmosis

    • Definitions and types of solutions.
    • Solubility is the amount of one substance that dissolves in another at a particular temperature.
    • Diffusion is the net movement of molecules down their concentration gradient.
    • Osmosis is the movement of water across a semipermeable membrane in response to concentration.

    Solution Concentrations

    • Molarity: moles of solute per liter of solution.
    • Molality: moles of solute per kilogram of solvent.
    • Percent by weight to volume (%w/v): grams of solute per 100 mL solution.
    • Percent by volume (%v/v): milliliters of solute per 100 ml of solution.
    • Normality (acid-base): equivalents of solute per liter of solution; analogous to molarity (but based on chemical reactivity, not mass).
    • Parts per million (ppm): grams of solute per 1,000,000 grams of solution.

    Solubility

    • Solubility is enhanced by similar intermolecular interactions between substances.
    • "Like dissolves like" (polar dissolves polar; nonpolar dissolves nonpolar).
    • Factors affecting solubility include intermolecular interactions, temperature, and pressure.
    • A saturated solution contains the maximum amount of a solute in a given solvent at a given temperature.

    Solubility & Temperature

    • Solubility typically increases with increasing temperature for solids and liquids but decreases for gases.

    Energy Changes & the Solution Process

    • Breaking bonds requires energy (endothermic); Forming bonds releases energy (exothermic).
    • Heat of solution is the energy change during solute dissolving in a solvent.
    • The enthalpy of solution (ΔHsoln) is numerically equal to the heat change, if the pressure remains constant.

    Energy Changes & the Solution Process

    • The solution process can be endothermic or exothermic, depending on the relative energies of bond breaking and bond formation.
    • Le Châtelier's principle states that systems at equilibrium respond to stress by shifting to restore equilibrium.

    Colligative Properties of Solutions

    • Vapor pressure depression describes how solute particles hinder solvent molecule escape, decreasing solution vapor pressure.
    • Boiling point elevation is the resultant increase in boiling temperature caused by solute presence.
    • Freezing point depression is the drop in freezing temperature due to solute interference.
    • Diffusion is the net movement of molecules to minimize concentration gradients.
    • Fick's law quantifies gas diffusion across membranes, considering partial pressure gradients, membrane solubility, area, thickness, and molecular weight.
    • Osmosis is water movement across semipermeable membranes due to solute concentration differences.
    • Osmotic and oncotic pressures balance fluid forces in capillary exchange. Differences in these pressures regulate fluid movement between blood and tissues.

    Other Acidic Species

    • Nonmetal oxides dissolved in water forms acidic solutions.
    • CO2 is a critical example, forming carbonic acid (H2CO3) when dissolved in water, impacting blood pH and oxygen transport.

    Buffers

    • A buffer solution maintains a stable pH when acids or bases are added.
    • It contains a weak acid and its conjugate base or a weak base and its conjugate acid.
    • Buffers resist changes in pH by neutralizing added acids or bases.

    Henderson-Hasselbalch Equation

    • The Henderson-Hasselbalch equation calculates the pH of a buffer solution considering the pKa of the weak acid and the ratio of the concentrations of the weak acid and its conjugate base.
    • The pH relative to the pKa determines whether the ionized or unionized form of a weak acid or base predominates.
    • The degree of ionization of a molecule increases as the pKa moves further from the physiological pH.

    Acid-Base Balance & Respiratory System

    • The respiratory system and kidneys work together to maintain normal blood pH.
    • The primary buffers are bicarbonate, phosphate, and proteins.
    • Key variables for assessing acid-base balance are blood pH, PaCO2 (partial pressure of carbon dioxide) and HCO3 (bicarbonate).
    • The respiratory system compensates for metabolic acid/base disturbances by altering ventilation.

    Other Important Concepts

    • Anion gap calculation helps evaluate the cause of metabolic acidosis.
    • Interpretation of blood gases (ABGs) clarifies acid-base imbalances.
    • Treatment for blood gas abnormalities involves adjusting ventilation for respiratory issues and addressing circulatory problems for metabolic issues.

    Diffusion/Anesthesia

    • Diffusion is a passive process driven by entropy.
    • Gases/liquids distribute uniformly over time.
    • Diffusion rates depend on the medium.
    • Nitrous oxide's diffusion into air-filled cavities is relevant clinically and can cause tissue damage.
    • Fick's Law describes gas diffusion across biological tissues, impacted by partial pressure, membrane solubility, area, thickness, and molecular weight.
    • Understanding Fick's law is crucial for a variety of medical scenarios.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Description

    Test your understanding of equilibrium constants, acid-base theories, and solubility principles in this comprehensive chemistry quiz. It covers key concepts such as the Brønsted definition, Le Châtelier's Principle, and Henry's Law. Evaluate your knowledge of strong acids, bases, and the effects of temperature and pressure on solubility.

    More Like This

    Equilibrium Constants Quiz
    15 questions
    Brønsted-Lowry Acid-Base Concepts
    5 questions
    Equilibrium Constants in Chemical Reactions
    34 questions
    Use Quizgecko on...
    Browser
    Browser