Chemistry: Bio-organic and Medicinal Chemistry Unit-III
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Questions and Answers

Which functional groups play a significant role in the structure-activity relationships of drug molecules?

  • -COOH group and -SH group
  • Aldehyde group and ester group
  • -OH group and -NH2 group (correct)
  • Triple bond and halogen groups

What is the classification of amino acids based on their zwitter ion structure?

  • Hydrophobic, hydrophilic, amphipathic
  • Neutral, acidic, basic (correct)
  • Primary, secondary, tertiary
  • Aliphatic, aromatic, polar

Which method is used to determine the N-terminal amino acid of a peptide?

  • DNFB method
  • Edman method (correct)
  • Thiohydantoin method
  • Carboxypeptidase enzyme method

Which structure of proteins involves the arrangement of multiple folded polypeptide chains?

<p>Quaternary structure (C)</p> Signup and view all the answers

What is the mechanism of enzyme action primarily based on?

<p>Lock-and-key or induced fit model (C)</p> Signup and view all the answers

In enzyme inhibition, what type of inhibition occurs when the inhibitor binds to a site other than the active site?

<p>Allosteric inhibition (B)</p> Signup and view all the answers

What is the mechanism that explains the conversion between alpha and beta forms of glucose?

<p>Lobry de Bruyn- van Ekenstein rearrangement (B)</p> Signup and view all the answers

Which of the following is a reducing sugar?

<p>Fructose (A)</p> Signup and view all the answers

What is the type of bond that links monosaccharides to form disaccharides?

<p>Glycosidic bond (A)</p> Signup and view all the answers

Which of the following is not a constituent of nucleic acids?

<p>Uracyl (C)</p> Signup and view all the answers

What is the primary function of DNA and RNA in biological systems?

<p>Genetic information storage and transmission (C)</p> Signup and view all the answers

In drug discovery, what does the Retrosynthetic approach primarily involve?

<p>Starting with the target compound and working backwards to simpler molecules (A)</p> Signup and view all the answers

Which law states that the interfacial angles in crystals remain constant?

<p>Law of constancy of interfacial angles (B)</p> Signup and view all the answers

What is the primary focus of Laue's method in determining crystal structures?

<p>Crystal structure determination (B)</p> Signup and view all the answers

Which type of polymers are characterized by being cross-linked or networked?

<p>Cross-linked polymers (A)</p> Signup and view all the answers

What is the primary bonding force in polymers known as?

<p>Secondary bond force (A)</p> Signup and view all the answers

Which method is used to determine the Weight Average Molecular Mass (Mw) of polymers?

<p>Gel permeation chromatography (C)</p> Signup and view all the answers

What is the primary focus of Ziegler-Natta polymerization?

<p>Chain-growth polymerization (A)</p> Signup and view all the answers

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