Chelation Therapy for Heavy Metal Toxicity

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18 Questions

Which adverse effect is associated with the administration of Dimercaprol?

Thrombocytopenia

What is the mechanism of action of Dimercaprol in treating metal poisoning?

Chelation of heavy metals

Which organ is primarily responsible for the excretion of Dimercaprol from the body?

Kidneys

What is a potential risk associated with the redistribution of arsenic and mercury to the central nervous system by Dimercaprol?

Neurotoxicity

How does Dimercaprol contribute to the reversal of metal-induced inhibition of sulfhydryl-containing enzymes?

By chelating metal ions

Which clinical finding is NOT commonly associated with the use of Dimercaprol?

Bradypnea

What is a common clinical finding associated with chronic inorganic arsenic poisoning?

Hyperpigmentation and hyperkeratosis of hands and feet

What is a key pharmacokinetic property of mercury?

Most concentrated in the kidneys

How is mercury commonly absorbed into the human body?

Inhalation of mercury vapors

What is a toxic effect of chronic exposure to inorganic arsenic on children?

Developmental delays and learning disabilities

Which of the following is NOT a mechanism of action of arsenic toxicity?

Cell apoptosis induction

What is a significant source of environmental release contributing to mercury bioaccumulation in fishes?

Burning of fossil fuels

Which factor determines the effectiveness of chelation therapy in removing a metal from a particular organ?

The half-life of the metal in that organ

What is a unique characteristic of the heavy metals that can be chelated by therapeutic agents?

They are always divalent cations

Why are chelators only effective when in their ionized form?

Ionized chelators have higher affinity for heavy metals

What is the main function of chelation therapy in the context of heavy metal toxicity?

To accelerate the elimination of heavy metals from the body

How does a therapeutic chelating agent affect the distribution of heavy metals to vital organs?

It may increase distribution to vital organs

In what form are chelators administered to effectively bind with heavy metals?

With a masking group that prevents binding initially

Explore drugs used to prevent or reverse the toxic effects of heavy metals on enzymes and cells, accelerating their elimination from the body. Learn how chelating agents prevent metal binding, disrupt cellular membranes, and redistribute metals to vital organs.

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