Chelation Therapy for Heavy Metal Toxicity

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Questions and Answers

Which adverse effect is associated with the administration of Dimercaprol?

  • Hypokalemia
  • Hypotension
  • Bradycardia
  • Thrombocytopenia (correct)

What is the mechanism of action of Dimercaprol in treating metal poisoning?

  • Enhancement of metal absorption
  • Chelation of heavy metals (correct)
  • Inhibition of free radical production
  • Neutralization of metal ions

Which organ is primarily responsible for the excretion of Dimercaprol from the body?

  • Lungs
  • Kidneys (correct)
  • Liver
  • Intestines

What is a potential risk associated with the redistribution of arsenic and mercury to the central nervous system by Dimercaprol?

<p>Neurotoxicity (B)</p> Signup and view all the answers

How does Dimercaprol contribute to the reversal of metal-induced inhibition of sulfhydryl-containing enzymes?

<p>By chelating metal ions (D)</p> Signup and view all the answers

Which clinical finding is NOT commonly associated with the use of Dimercaprol?

<p>Bradypnea (D)</p> Signup and view all the answers

What is a common clinical finding associated with chronic inorganic arsenic poisoning?

<p>Hyperpigmentation and hyperkeratosis of hands and feet (C)</p> Signup and view all the answers

What is a key pharmacokinetic property of mercury?

<p>Most concentrated in the kidneys (D)</p> Signup and view all the answers

How is mercury commonly absorbed into the human body?

<p>Inhalation of mercury vapors (D)</p> Signup and view all the answers

What is a toxic effect of chronic exposure to inorganic arsenic on children?

<p>Developmental delays and learning disabilities (A)</p> Signup and view all the answers

Which of the following is NOT a mechanism of action of arsenic toxicity?

<p>Cell apoptosis induction (D)</p> Signup and view all the answers

What is a significant source of environmental release contributing to mercury bioaccumulation in fishes?

<p>Burning of fossil fuels (B)</p> Signup and view all the answers

Which factor determines the effectiveness of chelation therapy in removing a metal from a particular organ?

<p>The half-life of the metal in that organ (C)</p> Signup and view all the answers

What is a unique characteristic of the heavy metals that can be chelated by therapeutic agents?

<p>They are always divalent cations (A)</p> Signup and view all the answers

Why are chelators only effective when in their ionized form?

<p>Ionized chelators have higher affinity for heavy metals (C)</p> Signup and view all the answers

What is the main function of chelation therapy in the context of heavy metal toxicity?

<p>To accelerate the elimination of heavy metals from the body (A)</p> Signup and view all the answers

How does a therapeutic chelating agent affect the distribution of heavy metals to vital organs?

<p>It may increase distribution to vital organs (A)</p> Signup and view all the answers

In what form are chelators administered to effectively bind with heavy metals?

<p>With a masking group that prevents binding initially (B)</p> Signup and view all the answers

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