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Questions and Answers
What is the mode of action of chelating agents in treating heavy metal poisoning?
What is the mode of action of chelating agents in treating heavy metal poisoning?
- Converting the metal in the body's tissues into harmless compounds which are then excreted through feces
- Interacting with the metal in the body's tissues to neutralize its toxic effects
- Forming a chelate with the metal in the body's tissues and then excreting it through the skin (correct)
- Binding to the metal in the body's tissues and forming a complex which is then excreted through the lungs
Which chelating agent is recommended for the removal of excess copper in patients with Wilson’s disease?
Which chelating agent is recommended for the removal of excess copper in patients with Wilson’s disease?
- Dimercaprol
- Calcium disodium edetate
- Penicillamine (correct)
- British anti-Lewisite
Which heavy metals are effectively treated using chelation therapy?
Which heavy metals are effectively treated using chelation therapy?
- Nickel and chromium
- Lead, mercury, and arsenic (correct)
- Cadmium and copper
- Iron and aluminum
How are chelating agents administered to patients for treating heavy metal poisoning?
How are chelating agents administered to patients for treating heavy metal poisoning?
What is the most common chelating agent used in the treatment of heavy-metal poisoning?
What is the most common chelating agent used in the treatment of heavy-metal poisoning?
Why is it very difficult to treat cadmium poisoning using chelation therapy?
Why is it very difficult to treat cadmium poisoning using chelation therapy?
Which chelating agent is used for the treatment of acute and chronic lead poisoning in both pediatrics and adult populations?
Which chelating agent is used for the treatment of acute and chronic lead poisoning in both pediatrics and adult populations?
Which chelating agent can be used as an antidote for arsenic, lead, gold, and mercury poisoning?
Which chelating agent can be used as an antidote for arsenic, lead, gold, and mercury poisoning?
Which chelating agent contains a disulfide group that can be transformed in the body to a dithiol group?
Which chelating agent contains a disulfide group that can be transformed in the body to a dithiol group?
Which chelating agent is indicated for the treatment of lead, arsenic, and mercury poisoning?
Which chelating agent is indicated for the treatment of lead, arsenic, and mercury poisoning?
Which chelating agent is a modification of BAL containing two thiol groups and two carboxylic acid groups?
Which chelating agent is a modification of BAL containing two thiol groups and two carboxylic acid groups?
Which chelating agent has an affinity for divalent and trivalent metals, forming stable, soluble complexes that are then excreted by the kidneys?
Which chelating agent has an affinity for divalent and trivalent metals, forming stable, soluble complexes that are then excreted by the kidneys?
Which chelating agent competes with enzymes for the coordination of heavy metals and forms a chelated complex that is then excreted in the urine?
Which chelating agent competes with enzymes for the coordination of heavy metals and forms a chelated complex that is then excreted in the urine?
'Edetate' refers to the calcium disodium salt of which chelating agent?
'Edetate' refers to the calcium disodium salt of which chelating agent?
'2,3-dimercapto-1-propanol' is the chemical name for which chelating agent used for lead poisoning along with Disodium edetate?
'2,3-dimercapto-1-propanol' is the chemical name for which chelating agent used for lead poisoning along with Disodium edetate?
Which chelating agent forms strong complexes with lead, zinc, cadmium, manganese, iron, and mercury?
Which chelating agent forms strong complexes with lead, zinc, cadmium, manganese, iron, and mercury?
Study Notes
Chelating Agents in Heavy Metal Poisoning
- Chelating agents work by forming stable, soluble complexes with heavy metals, which are then excreted by the kidneys, thereby removing the toxic metal from the body.
Chelating Agents for Specific Heavy Metals
- For Wilson's disease, penicillamine is recommended for removing excess copper.
- Chelation therapy is effective for treating lead, mercury, arsenic, and gold poisoning.
Administration of Chelating Agents
- Chelating agents are administered to patients to treat heavy metal poisoning, and the route of administration depends on the specific agent and patient needs.
Common Chelating Agents
- Dimercaprol (BAL) is the most commonly used chelating agent for treating heavy-metal poisoning.
- DMSA is used for the treatment of acute and chronic lead poisoning in both pediatric and adult populations.
- DMSA can also be used as an antidote for arsenic, lead, gold, and mercury poisoning.
- EDTA is a chelating agent that has an affinity for divalent and trivalent metals, forming stable, soluble complexes that are then excreted by the kidneys.
- EDTA competes with enzymes for the coordination of heavy metals and forms a chelated complex that is then excreted in the urine.
Properties of Chelating Agents
- DMSA contains a disulfide group that can be transformed in the body to a dithiol group.
- DMSA is indicated for the treatment of lead, arsenic, and mercury poisoning.
- EDTA is a modification of BAL containing two thiol groups and two carboxylic acid groups.
- DTPA forms strong complexes with lead, zinc, cadmium, manganese, iron, and mercury.
Specific Chelating Agents
- 'Edetate' refers to the calcium disodium salt of EDTA.
- '2,3-dimercapto-1-propanol' is the chemical name for BAL used for lead poisoning along with Disodium edetate.
Challenges of Chelation Therapy
- Cadmium poisoning is difficult to treat using chelation therapy due to the complexity of cadmium's chemical properties.
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Description
Learn about the chelating agents used to treat heavy metal poisoning such as lead, mercury, arsenic, and cadmium. Understand the administration and effectiveness of chelation therapy as a treatment option.
