Characterisation of Broadly Neutralizing Therapies Quiz-dr templeton
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Questions and Answers

What is the primary method used to propagate influenza virus for the production of split virion vaccines?

  • Propagation in chicken eggs (correct)
  • Cell-based propagation
  • Propagation in plants
  • Propagation in mammalian cells

    • What is the main purpose of disrupting virus particles with detergents in the creation of split virion vaccines?

  • To release haemagglutinin and neuraminidase glycoproteins (correct)
  • To destroy the virus particles
  • To decrease the side effects of the vaccine
  • To increase the potency of the vaccine

    • Why were routine influenza vaccines extended to children in the mid-2010s?

  • Children were at a higher risk of severe infection
  • Children demanded vaccination
  • Existing vaccines were ineffective in adults
  • Children were more likely to spread the infection (correct)

    • Which population is NOT typically considered 'at risk' for routine influenza vaccination?

    <p>Healthy adults aged 25-40</p> Signup and view all the answers

    What is the primary factor determining the strains included in new influenza vaccines each year?

    <p>Assessment of strains circulating during the Winter season in the opposing hemisphere</p> Signup and view all the answers

    Why were routine vaccination recommendations extended to individuals 50yrs+?

    <p>Concern over potential co-infections with COVID19 during the pandemic</p> Signup and view all the answers

    Which type of influenza vaccine is administered via nasal spray and is recommended for healthy individuals?

    <p>Live attenuated influenza vaccine (LAIV)</p> Signup and view all the answers

    Which of the following is NOT a benefit of a universal flu vaccine?

    <p>Reduce the severity of symptoms in infected individuals</p> Signup and view all the answers

    Which type of antibody is not directly correlated with protection against SARS-CoV-2 reinfection before vaccination?

    <p>Anti-SARS-CoV-2 nucleocapsid (anti-N)</p> Signup and view all the answers

    Which of the following is the LEAST likely reason for the development of a universal flu vaccine?

    <p>Increase the risk of vaccine mismatch</p> Signup and view all the answers

    Which of the following is NOT a method used to determine correlates of immunity against SARS-CoV-2?

    <p>PCR testing</p> Signup and view all the answers

    Which type of influenza vaccine contains 2 Flu B strains?

    <p>Quadrivalent inactivated vaccine (QIV)</p> Signup and view all the answers

    Which vaccine platform uses genetic material from a different, harmless virus to deliver instructions for making the spike protein found on the surface of the COVID-19 virus?

    <p>Viral vector vaccine</p> Signup and view all the answers

    Which vaccine technology requires a two-dose regimen with an interval of 21 days and uses mRNA to instruct cells to produce spike proteins?

    <p>BNT162b2 vaccine</p> Signup and view all the answers

    Which vaccine platform demonstrated high efficacy in Phase 3 trials and does not involve the use of genetic material from the COVID-19 virus?

    <p>Protein subunit platform</p> Signup and view all the answers

    Which vaccine platform has a single-dose regimen and uses a harmless virus to deliver genetic material from the COVID-19 virus?

    <p>AZD1222 vaccine</p> Signup and view all the answers

    Which vaccine platform uses mRNA to instruct cells to produce spike proteins and has examples such as Pfizer and Moderna vaccines?

    <p>mRNA vaccine</p> Signup and view all the answers

    Which vaccine platform uses a harmless virus to deliver genetic material from the COVID-19 virus and has an example such as the Johnson & Johnson's Janssen COVID-19 vaccine?

    <p>Viral vector vaccine</p> Signup and view all the answers

    In the context of a random effects model, what is the value of I² for heterogeneity?

    <p>37%</p> Signup and view all the answers

    Which study has the largest sample size according to the given data?

    <p>Nguyen et al. 2022</p> Signup and view all the answers

    What is the correlation coefficient for cluster 5 in the given data?

    <p>0.82</p> Signup and view all the answers

    Which study has the highest weight in the random effects model?

    <p>Wohlgemuth et al. 2021</p> Signup and view all the answers

    What is the pooled correlation of the 50 Pearson's correlation coefficients?

    <p>0.86</p> Signup and view all the answers

    Which type of COVID-19 vaccine contains harmless S proteins?

    <p>Protein subunit vaccine</p> Signup and view all the answers

    What is the p-value for the correlation between PV Core and Pearson's correlation?

    <p>0.306</p> Signup and view all the answers

    What is the 95% confidence interval for the correlation coefficient of cluster 2?

    <p>[0.84; 1.00]</p> Signup and view all the answers

    Which sample type has the smallest number of observations in the given data?

    <p>Human mAbs</p> Signup and view all the answers

    What is the correlation coefficient for cluster 10?

    <p>0.86</p> Signup and view all the answers

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