10 Questions
What is the primary reason that ABO incompatibility rarely causes hemolytic disease of the fetus and newborn (HDFN)?
IgM antibodies against A and B antigens do not cross the placenta.
What is the primary reason why the D antigen is considered the most immunogenic after A and B antigens?
The number of epitopes present on the D antigen.
Why is RhD testing considered sufficient for most clinical purposes?
RhD is the most important immunogenic antigen in the Rh system.
What is a key factor affecting the immunogenicity of an antigen?
Antigen size and shape.
Why are RBCs from individuals homozygous for a specific allele more reactive to antibodies?
Increased number of epitopes present due to zygosity.
What is one notable difference between ABO and Rh blood group systems in terms of immunogenicity?
Immunogenicity does not correlate with hemolytic potential in ABO system.
What is the significance of A and B transferases having only four amino acid differences in their catalytic domain?
Affects substrate specificity and antigen expression.
Why is passive immunization against D recommended for mothers at risk during pregnancy?
'D' sensitization poses a risk to subsequent pregnancies.
What defines an antithetical antigen?
Different alleles that lead to increased dosage effect
Why are C, c, E, and e antigens considered less immunogenic?
The number of epitopes they present
Explore the definition and history of blood group systems, including genetically discrete blood groups and different categories of blood group antigens. Learn about inherited carbohydrates or proteins located on the outside surface of red blood cells.
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