Podcast
Questions and Answers
What is the primary reason that ABO incompatibility rarely causes hemolytic disease of the fetus and newborn (HDFN)?
What is the primary reason that ABO incompatibility rarely causes hemolytic disease of the fetus and newborn (HDFN)?
- IgM antibodies against A and B antigens do not cross the placenta. (correct)
- ABO antigens are not expressed on the fetus's red blood cells.
- H antigen is present on all erythrocytes.
- ABO antibodies are not produced during pregnancy.
What is the primary reason why the D antigen is considered the most immunogenic after A and B antigens?
What is the primary reason why the D antigen is considered the most immunogenic after A and B antigens?
- The location of the D antigen on the RBC membrane.
- The shape of the D antigen.
- Structural rigidity of the D antigen.
- The number of epitopes present on the D antigen. (correct)
Why is RhD testing considered sufficient for most clinical purposes?
Why is RhD testing considered sufficient for most clinical purposes?
- RhD status correlates with RhCE presence.
- RhD is the most frequently encountered Rh antigen.
- RhD is the only immunogenic Rh antigen.
- RhD is the most important immunogenic antigen in the Rh system. (correct)
What is a key factor affecting the immunogenicity of an antigen?
What is a key factor affecting the immunogenicity of an antigen?
Why are RBCs from individuals homozygous for a specific allele more reactive to antibodies?
Why are RBCs from individuals homozygous for a specific allele more reactive to antibodies?
What is one notable difference between ABO and Rh blood group systems in terms of immunogenicity?
What is one notable difference between ABO and Rh blood group systems in terms of immunogenicity?
What is the significance of A and B transferases having only four amino acid differences in their catalytic domain?
What is the significance of A and B transferases having only four amino acid differences in their catalytic domain?
Why is passive immunization against D recommended for mothers at risk during pregnancy?
Why is passive immunization against D recommended for mothers at risk during pregnancy?
What defines an antithetical antigen?
What defines an antithetical antigen?
Why are C, c, E, and e antigens considered less immunogenic?
Why are C, c, E, and e antigens considered less immunogenic?
