Blood Group Systems and Inheritance
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Questions and Answers

Which chromosomes are most blood group genes located on?

  • Both sex and autosomal chromosomes
  • Mitochondrial chromosomes
  • Sex chromosomes
  • Autosomal chromosomes (correct)
  • What type of inheritance do most blood group alleles demonstrate?

  • Codominance (correct)
  • Polygenic inheritance
  • Incomplete dominance
  • Epistasis
  • What is the result of paired chromosomes carrying the same silent allele?

  • Recessive phenotype
  • Null phenotype (correct)
  • Intermediate phenotype
  • Dominant phenotype
  • What can null phenotype RBCs be helpful for?

    <p>Identifying high-prevalence antigens</p> Signup and view all the answers

    Do regulator or modifying genes necessarily have to be located at the same locus as the blood group genes they affect?

    <p>No</p> Signup and view all the answers

    Which of the following accurately describes the naming conventions for blood group antigens?

    <p>Antigen names are written in regular type without italics or underlining, while genes are written in italics or underlined.</p> Signup and view all the answers

    What does the plus sign or minus sign written on the same line as an antigen indicate?

    <p>The presence or absence of the antigen</p> Signup and view all the answers

    When testing for both antithetical antigens, how are the results written?

    <p>Both results are written within parentheses</p> Signup and view all the answers

    What is a phenotype in the context of blood group antigens?

    <p>The presence or absence of the antigen</p> Signup and view all the answers

    How have blood group antigens been named over the last century?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is true about blood group antigens?

    <p>They are codominant and express corresponding antigens.</p> Signup and view all the answers

    Which of the following is an example of a complex structure that carries more than one antigen?

    <p>The S or s antigen.</p> Signup and view all the answers

    What is the role of regulator or modifying genes in blood group systems?

    <p>They alter antigen expression and may segregate independently of the blood group genes they affect.</p> Signup and view all the answers

    How are alloantibodies that detect blood group antigens produced?

    <p>They are produced in response to exposure to nonself RBC antigens introduced by blood transfusion or pregnancy.</p> Signup and view all the answers

    Which gene must be present for conversion to Leb?

    <p>Se</p> Signup and view all the answers

    What is the ISBT system number assigned to the Lewis blood group system?

    <p>007</p> Signup and view all the answers

    Which individuals are mostly nonsecretors of ABH?

    <p>Le(a+b–) RBCs</p> Signup and view all the answers

    Which population is the Le(a–b–) phenotype found more frequently among?

    <p>Africans</p> Signup and view all the answers

    Which tissues are Lewis antigens found on, apart from RBCs?

    <p>Pancreas and stomach</p> Signup and view all the answers

    Which enzyme treatment can enhance the reactivity of Lewis antibodies?

    <p>Ficin and papain</p> Signup and view all the answers

    Which gene is responsible for the conversion of a precursor substance to Lea?

    <p>Le</p> Signup and view all the answers

    What is the function of the Se gene in the conversion of a precursor substance to Leb?

    <p>Encodes the secretor antigen</p> Signup and view all the answers

    Which blood group system was the Lewis system named after?

    <p>Mourant</p> Signup and view all the answers

    Which population has the highest prevalence of the Le(a+b+) phenotype?

    <p>Asians</p> Signup and view all the answers

    Which of the following tissues do Lewis antigens NOT express on?

    <p>Liver</p> Signup and view all the answers

    Which Lewis antibody is the most commonly encountered?

    <p>Anti-Lea</p> Signup and view all the answers

    When do Lewis glycolipids become detectable in the plasma of newborns?

    <p>10 days after birth</p> Signup and view all the answers

    Which phenotype do individuals with lele genes exhibit throughout their lives?

    <p>Le(a–b–)</p> Signup and view all the answers

    Which antigen is expressed on all RBCs except those of the very rare p phenotype?

    <p>Pk</p> Signup and view all the answers

    Which of the following phenotypes describes RBCs that react with anti-P1 and anti-P?

    <p>P1+</p> Signup and view all the answers

    Which of the following phenotypes describes RBCs that do not react with anti-P1 but do react with anti-P?

    <p>P2</p> Signup and view all the answers

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