31 Questions
Which chromosomes are most blood group genes located on?
Autosomal chromosomes
What type of inheritance do most blood group alleles demonstrate?
Codominance
What is the result of paired chromosomes carrying the same silent allele?
Null phenotype
What can null phenotype RBCs be helpful for?
Identifying high-prevalence antigens
Do regulator or modifying genes necessarily have to be located at the same locus as the blood group genes they affect?
No
Which of the following accurately describes the naming conventions for blood group antigens?
Antigen names are written in regular type without italics or underlining, while genes are written in italics or underlined.
What does the plus sign or minus sign written on the same line as an antigen indicate?
The presence or absence of the antigen
When testing for both antithetical antigens, how are the results written?
Both results are written within parentheses
What is a phenotype in the context of blood group antigens?
The presence or absence of the antigen
How have blood group antigens been named over the last century?
All of the above
Which of the following is true about blood group antigens?
They are codominant and express corresponding antigens.
Which of the following is an example of a complex structure that carries more than one antigen?
The S or s antigen.
What is the role of regulator or modifying genes in blood group systems?
They alter antigen expression and may segregate independently of the blood group genes they affect.
How are alloantibodies that detect blood group antigens produced?
They are produced in response to exposure to nonself RBC antigens introduced by blood transfusion or pregnancy.
Which gene must be present for conversion to Leb?
Se
What is the ISBT system number assigned to the Lewis blood group system?
007
Which individuals are mostly nonsecretors of ABH?
Le(a+b–) RBCs
Which population is the Le(a–b–) phenotype found more frequently among?
Africans
Which tissues are Lewis antigens found on, apart from RBCs?
Pancreas and stomach
Which enzyme treatment can enhance the reactivity of Lewis antibodies?
Ficin and papain
Which gene is responsible for the conversion of a precursor substance to Lea?
Le
What is the function of the Se gene in the conversion of a precursor substance to Leb?
Encodes the secretor antigen
Which blood group system was the Lewis system named after?
Mourant
Which population has the highest prevalence of the Le(a+b+) phenotype?
Asians
Which of the following tissues do Lewis antigens NOT express on?
Liver
Which Lewis antibody is the most commonly encountered?
Anti-Lea
When do Lewis glycolipids become detectable in the plasma of newborns?
10 days after birth
Which phenotype do individuals with lele genes exhibit throughout their lives?
Le(a–b–)
Which antigen is expressed on all RBCs except those of the very rare p phenotype?
Pk
Which of the following phenotypes describes RBCs that react with anti-P1 and anti-P?
P1+
Which of the following phenotypes describes RBCs that do not react with anti-P1 but do react with anti-P?
P2
Test your knowledge on blood group systems and inheritance with this quiz. Learn about antigens, alleles, and Mendelian inheritance patterns. Discover how blood group genes are located on autosomal chromosomes and express corresponding antigens.
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