CFTR Mutation Pathophysiology

What is the main consequence of defective CFTR in cystic fibrosis?

Which system is the most affected in cystic fibrosis?

What is the major cause of morbidity and mortality in cystic fibrosis?

What happens to the viscosity of secretions in cystic fibrosis?

What is the most common pathogen causing disease in CF patients?

How does defective CFTR affect airway surface liquid?

What are the major long-term complications of cystic fibrosis?

What happens to sputum in cystic fibrosis that facilitates pathogen colonization?

What is the most common Burkholderia cepacia complex species found in people with cystic fibrosis?

Which Burkholderia cepacia complex species produces a melanin-like pigment that helps evade oxidative killing in the host?

What is the unique characteristic of Stenotrophomonas maltophilia among the mentioned bacteria?

What makes Burkholderia cepacia complex resistant to antibiotics according to the text?

Which bacterium is described as an environmental bacteria that lives in water, aquatic areas, and wet surfaces?

Which Burkholderia cepacia complex species contributes more to Cepacia syndrome due to its inflammatory nature?

What characteristic of B. cepacia contributes to its survival in the lungs?

Which pathogen is a common clinical pathogen causing a wide range of infections in skin, soft tissue, and deep tissues?

What is the leading cause of bloodstream and lower respiratory tract infections according to the text?

Which pathogen is a dominant pathogen in people with cystic fibrosis contributing to morbidity and mortality?

What is attributed to the adaptability and flexibility of Pseudomonas aeruginosa in causing chronic infections?

Which pathogen has been observed to undergo pathoadaptative changes in response to the stressful environment of the CF airway?

What is the main virulence factor produced by Pseudomonas aeruginosa that can break down lung tissue?

Which virulence factor of Staphylococcus aureus binds to antibodies, preventing bacterial opsonization?

What type of virulence factor does Burkholderia cepacia complex produce to scavenge iron from the host?

Which pathogen associated with CF lung disease is known for producing biofilms that protect it from the host immune response and antibiotics?

What is the specific toxin produced by Pseudomonas aeruginosa that contributes to inflammation and tissue damage in the lungs?

Which enzyme produced by Staphylococcus aureus contributes to tissue damage?

What is the primary effect of alginate produced by Pseudomonas aeruginosa?

Which bacterial group produces toxins and enzymes that contribute to tissue damage and inflammation?

What type of bacteria is Moraxella catarrhalis?

Which virulence factor is NOT produced by Stenotrophomonas maltophilia?

What infections can be caused by Moraxella catarrhalis according to the text?

Which bacterial species mentioned is fastidious and facultative aerobic?

What characteristic distinguishes Hemophilus influenza type B (HiB) from Stenotrophomonas maltophilia?

Which bacterium causes endophthalmitis among other infections?

In penicillin-resistant infections, which enzyme is commonly produced by Moraxella catarrhalis?

What distinguishes Stenotrophomonas maltophilia from Acromobacter xylosoxidans based on the text?