L23 SAQ - Cerebrospinal Fluid Quiz

CSF acts as a buoyancy aid and cushion for the brain, as well as facilitating the delivery of oxygen and nutrients to a local area.

CSF fills the subarachnoid space and allows the brain to float, reducing its effective weight.

The normal range of ICP is 120-180 mmCSF or 9-14 mmHg.

<p>ICP can be significantly raised through obstruction of the venous system, intracranial mass, or brain edema.</p> Signup and view all the answers

<p>Direct ICP recording can be done through icv, subarachnoid, or subdural CSF pressure measurement.</p> Signup and view all the answers

<p>The normal values for CSF analysis in the L3-4 interspace are: clear color, no RBCs, 0-6mm3 WBCs, 15-45 mg/100 ml protein, and 50-75 mg/100 ml glucose.</p> Signup and view all the answers

<p>High protein levels in CSF can indicate conditions such as tumour, abscess, cyst, or hydrocephalus.</p> Signup and view all the answers

<p>A cloudy appearance of CSF can indicate an increased cell count or infection.</p> Signup and view all the answers

<p>Yellow color of CSF can indicate the presence of red blood cells (RBCs), which may be due to a traumatic tap or subarachnoid hemorrhage.</p> Signup and view all the answers

<p>Circumventricular organs are sites outside the blood-brain barrier that play a role in physiological and endocrine feedback systems within the brain.</p> Signup and view all the answers

<p>The blood brain barrier is a highly regulated barrier formed by the endothelial cells of capillaries and the endfeet of astrocytes. It restricts the movement of substances from the blood into the brain, allowing only certain molecules to pass through. This barrier is important as it protects the brain from potentially harmful substances and maintains a stable environment for optimal brain function.</p> Signup and view all the answers

<p>Substances can move across the capillary membrane into the brain through passive diffusion, facilitated diffusion, active transport, vesicular transfer, transcytosis, and paracellular aqueous transfer.</p> Signup and view all the answers

<p>Passive diffusion is the movement of substances from an area of higher concentration to an area of lower concentration, without the need for energy. It is directly proportional to lipid solubility, meaning substances that are more lipid-soluble diffuse more easily. It is inversely proportional to size, with smaller molecules diffusing more easily than larger ones.</p> Signup and view all the answers

<p>Astrocytes play a crucial role in the blood brain barrier by inducing the formation of tight junctions between the endothelial cells of capillaries. These tight junctions enhance the barrier function, preventing the passage of most substances from the blood into the brain.</p> Signup and view all the answers

<p>Cerebrospinal fluid serves as a 'sink' of extracellular fluid that is filtered from the blood and supplies and drains the interstitium of the brain. It helps in maintaining a stable environment for optimal brain function.</p> Signup and view all the answers

<p>Cerebrospinal fluid is found in the ventricles (approximately 25ml), spinal cord central canal (approximately 30ml), and sub-arachnoid space (majority of volume).</p> Signup and view all the answers

<p>The systolic pulsations of the arterial system cause compression of the ventricles and subarachnoid space, creating movement of cerebrospinal fluid.</p> Signup and view all the answers

<p>The rate of production of cerebrospinal fluid is approximately 550 ml per day or 0.35 ml per minute.</p> Signup and view all the answers

<p>Cerebrospinal fluid is reabsorbed through arachnoid villi into veins via venous sinuses.</p> Signup and view all the answers

<p>Cerebrospinal fluid turnover occurs approximately 3.7 times per day.</p> Signup and view all the answers