Podcast
Questions and Answers
Which of the following is NOT a function of cerebrospinal fluid (CSF)?
Which of the following is NOT a function of cerebrospinal fluid (CSF)?
What is the approximate weight of the brain when it is floating in CSF?
What is the approximate weight of the brain when it is floating in CSF?
Which of the following can significantly raise intracranial pressure (ICP)?
Which of the following can significantly raise intracranial pressure (ICP)?
What is the normal range for CSF pressure as a guide of ICP?
What is the normal range for CSF pressure as a guide of ICP?
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What can a cloudy appearance of CSF indicate?
What can a cloudy appearance of CSF indicate?
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Which of the following is NOT a potential cause of high CSF protein levels?
Which of the following is NOT a potential cause of high CSF protein levels?
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What is the normal range for CSF glucose levels?
What is the normal range for CSF glucose levels?
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What is the purpose of circumventricular organs in the brain?
What is the purpose of circumventricular organs in the brain?
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What is the composition of extracellular fluid in the central nervous system (CNS) regulated by?
What is the composition of extracellular fluid in the central nervous system (CNS) regulated by?
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What is the purpose of the rapid venous drainage from circumventricular organs?
What is the purpose of the rapid venous drainage from circumventricular organs?
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Which body fluid compartment is cerebrospinal fluid a 'sink' of extracellular fluid filtered from blood?
Which body fluid compartment is cerebrospinal fluid a 'sink' of extracellular fluid filtered from blood?
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What is the rate of production of cerebrospinal fluid per day?
What is the rate of production of cerebrospinal fluid per day?
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How is cerebrospinal fluid reabsorbed into veins?
How is cerebrospinal fluid reabsorbed into veins?
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What type of movement of substances across the capillary membrane into the brain is directly proportional to lipid solubility and inversely proportional to size?
What type of movement of substances across the capillary membrane into the brain is directly proportional to lipid solubility and inversely proportional to size?
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What induces tight junctions between endothelial cells of capillaries and the endfeet of astrocytes?
What induces tight junctions between endothelial cells of capillaries and the endfeet of astrocytes?
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What is the main body fluid compartment where the majority of cerebrospinal fluid is located?
What is the main body fluid compartment where the majority of cerebrospinal fluid is located?
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What causes the movement of cerebrospinal fluid in the ventricles and subarachnoid space?
What causes the movement of cerebrospinal fluid in the ventricles and subarachnoid space?
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What is the turnover rate of cerebrospinal fluid per day?
What is the turnover rate of cerebrospinal fluid per day?
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What is the recommended reading for further information on cerebrospinal fluid?
What is the recommended reading for further information on cerebrospinal fluid?
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What is the role of macroglia in the movement of substances across the capillary membrane into the brain?
What is the role of macroglia in the movement of substances across the capillary membrane into the brain?
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Study Notes
Cerebrospinal Fluid (CSF) Functions
- CSF does not have a function of storing nutrients or waste products.
Brain and CSF Weight
- The brain weighs approximately 1400-1500 grams when floating in CSF.
Intracranial Pressure (ICP)
- Factors that can significantly raise ICP include brain tumors, cerebral edema, and meningitis.
CSF Pressure and ICP
- The normal range of CSF pressure as a guide of ICP is 7-15 mmHg.
CSF Appearance and Protein Levels
- A cloudy appearance of CSF can indicate the presence of white blood cells or bacteria.
- A potential cause of high CSF protein levels is multiple sclerosis.
CSF Glucose Levels
- The normal range for CSF glucose levels is 2.5-4.5 mmol/L.
Circumventricular Organs
- The purpose of circumventricular organs in the brain is to monitor the chemical composition of the blood and CSF.
- These organs regulate the composition of extracellular fluid in the central nervous system (CNS).
CSF Reabsorption and Production
- CSF is reabsorbed into veins through the arachnoid villi.
- The rate of production of CSF is approximately 500-600 mL/day.
- The turnover rate of CSF is approximately 3-4 times per day.
Capillary Membrane and Astrocytes
- The movement of substances across the capillary membrane into the brain is directly proportional to lipid solubility and inversely proportional to size.
- Tight junctions between endothelial cells of capillaries and the endfeet of astrocytes are induced by the blood-brain barrier.
CSF Location and Movement
- The main body fluid compartment where the majority of CSF is located is the subarachnoid space.
- The movement of CSF in the ventricles and subarachnoid space is caused by the pulsatile flow of cerebral arteries.
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Description
Test your knowledge on cerebrospinal fluid and its role in the body. This quiz covers topics such as transcellular fluid, the blood-brain barrier, and movement of substances into the brain. Recommended reading: Neuroscience 6/e by Purves et al.
