65 Questions
Which class of antibiotics covers pseudomonas and contains agents that resist degradation by beta-lactamases?
Carbapenems
Which cephalosporin covers MRSA infections?
Cefepime
Which antibiotic class is characterized by having excellent coverage against Gram-negative infections including pseudomonas but lacks reliable Gram-positive or anaerobic coverage?
Monobactam
Which antibiotic class inhibits cell wall synthesis by binding the terminal molecule of the peptidoglycan?
Glycopeptides
Among the following, which antibiotic is used first-line to treat C.difficile infection and MRSA bacteremia?
Vancomycin
Which class of antibiotics is known to hydrolyze all ß-lactam antibiotics except aztreonam?
Carbapenems
Which antibiotic class is NOT affected by clavulanic acid or tazobactam?
Monobactam
Which antibiotic class is characterized by being active against Gram positive agents including MRSA but having no anaerobic coverage?
Glycopeptides
Which antibiotic class has the characteristic of destroying the cell membrane by direct chemical interaction with LPS?
Polymyxins
Which class of antibiotics treats rickettsial infections and is active against both Gram positive and Gram negative organisms?
Tetracyclines
Which of the following cell wall inhibitors primarily targets Gram negative organisms?
Fosfomycin
Which antibiotic is associated with the unique toxicity of encephalitis?
Cefepime
Which class of ß-lactamases requires zinc and can hydrolyze penicillins and carbapenems?
Metallo ß-lactamses
Which cell wall inhibitor is mainly used topically for wounds and burn injuries?
Bacitracin
Which of the following antibiotics is NOT associated with renal toxicity?
Bacitracin
What is the general mechanism of action of penicillins?
Inhibition of cell wall synthesis
Which type of infection is NOT reliably covered by penicillin G and V?
Staphylococcus infections
What is the main difference between oral Penicillin V and intramuscular Penicillin G?
Method of administration
Which antibiotic class includes drugs like Cephalosporins and Monobactam?
Penicillins
What is the primary target of Carbapenems in bacterial cells?
Cell wall synthesis
Which organism is NOT covered by aminopenicillins?
Staphylococcus
Why are beta-lactamases a concern in antibiotic resistance?
They break down beta-lactam antibiotics
Which penicillin-based drug reliably covers streptococcus and staphylococcus infections?
Oxacillin
What makes the 5th generation cephalosporins unique?
They cover MRSA infections
Which class of antibiotics includes agents that cover pseudomonas infections?
Carbapenems
Which antibiotic class among penicillins, monobactam, cephalosporins, glycopeptides, and carbapenems is characterized by being active against Gram positive infections, including MRSA, but lacks reliable Gram negative or anaerobic coverage?
Glycopeptides
Which antibiotic class contains only one agent (Aztreonam) and has excellent coverage against Gram negative infections, including pseudomonas, but lacks reliable Gram positive or anaerobic coverage?
Monobactam
Which antibiotic class is known for resisting degradation by beta-lactamases and includes agents that cover pseudomonas, with the exception of one agent (ertapenem)?
Carbapenems
Among the classes of antibiotics discussed, which one inhibits cell wall synthesis by binding the terminal molecule of the peptidoglycan and prevents further elongation of cell wall polymers?
Glycopeptides
Which antibiotic class is specifically highlighted as not containing a beta-lactam ring and consequently does not work by inhibiting PBP in bacterial cells?
Monobactam
Which antibiotic class is known for reliably covering streptococcus and staphylococcus infections, but does NOT cover Gram-negative, anaerobic, or methicillin-resistant staphylococcus aureus (MRSA) infections?
Aminopenicillins
Which beta-lactam antibiotic is unique because it has a modification in structure that makes the drug molecule bulky to resist breakdown by enzymes and reliably covers streptococcus and staphylococcus infections?
Oxacillin
Among the following antibiotic classes, which one is NOT reliably covered by aminopenicillins when it comes to Pseudomonas infections?
Monobactams
Which antibiotic class contains agents that are mainly used topically for wounds and burn injuries?
Penicillins
Which class of antibiotics contains drugs that cover Pseudomonas infections and resist degradation by beta-lactamases?
Monobactams
Which antibiotic inhibits pyruvyl-transferase, an enzyme required for cell wall synthesis?
Fosfomycin
Which antibiotic class is known for causing seizures by lowering the seizure threshold?
Carbapenems
What sets the 5th generation cephalosporins apart from other generations of cephalosporins in terms of their coverage?
They cover MRSA infections
Which antibiotic class is mainly used to treat urinary tract infections and is active against Gram-negative organisms?
Monobactams
Which antibiotic class is NOT covered in the text provided?
Macrolides
Which antibiotic class is known for its activity against both Gram positive and Gram negative organisms, treating rickettsial infections, and includes drugs like Tetracyclines and Aminoglycosides?
Cephalosporins
Which antibiotic class is NOT inhibited by clavulanic acid or tazobactam, has no reliable anaerobic coverage, and can hydrolyze all ß-lactam antibiotics except aztreonam?
Carbapenems
Which antibiotic class includes Daptomycin that penetrates the cell membrane resulting in efflux of K+ from bacterial cell, is only active against Gram positive agents including MRSA, and cannot be used for lung infections?
Glycopeptides
Which antibiotic class contains agents like Polymyxins that have detergent-like activity, destroy the cell membrane by direct chemical interaction with LPS, and are only active against Gram negative agents?
Monobactam
Which antibiotic class is characterized by inhibiting protein synthesis by targeting either the 30S or 50S ribosomal subunit, and includes antibiotics like Tetracyclines and Aminoglycosides?
Glycopeptides
What is the unique characteristic of Penicillin G administration?
Intramuscular administration
Which type of infection is reliably covered by Penicillin V?
Streptococcus infections
What is the primary mechanism of action of Monobactam antibiotics?
Inhibition of cell wall synthesis
Which antibiotic class provides coverage against Gram-negative infections including Pseudomonas but lacks reliable Gram-positive or anaerobic coverage?
Monobactam
What is the main difference between Penicillins and Cephalosporins?
Coverage spectrum
Which antibiotic is primarily associated with the unique toxicity known as 'Gray baby syndrome'?
Ampicillin/Sulbactam
Which antibiotic class includes drugs that are NOT affected by clavulanic acid or tazobactam?
Monobactam
Which antibiotic class is characterized by having excellent coverage against Gram-negative infections but lacks reliable Gram-positive or anaerobic coverage?
Cephalosporins
Which cell wall inhibitor is mainly used topically for wounds and burn injuries?
Chloramphenicol
Which antibiotic class has the characteristic of destroying the cell membrane by direct chemical interaction with lipopolysaccharides (LPS)?
Glycopeptides
Which antibiotic class is primarily used for the treatment of C.difficile infections?
Cephalosporins
Which antibiotic class is known for its activity against both Gram positive and Gram negative organisms but lacks reliable anaerobic coverage?
Penicillins
Which of the following antibiotic classes primarily targets MRSA and vancomycin-resistant enterococcus infections?
Glycopeptides
Which antibiotic class is characterized by its activity against Gram positive organisms and anaerobes?
Glycopeptides
Among the listed antibiotic classes, which one is least commonly used for antibiotic treatment according to the text?
Monobactam
Which antibiotic class has been associated with a high risk of pseudomembranous colitis?
Cephalosporins
Which antibiotic class is NOT typically resistant to degradation by beta-lactamases?
Carbapenems
Which antibiotic class is characterized by being active against MRSA but lacking reliable coverage against Gram-negative organisms?
Glycopeptides
Among Penicillins, Monobactam, Cephalosporins, and Carbapenems, which class is primarily active against Gram-positive organisms such as MRSA and anaerobes?
Carbapenems
Which antibiotic class is mainly reserved for methicillin-resistant Staphylococcus aureus (MRSA) infections?
Carbapenems
Study Notes
Antibiotic Classes
- Cephalosporins that cover MRSA infections include cephalosporin antibiotics.
- The class of antibiotics that covers pseudomonas and resists degradation by beta-lactamases is Monobactam.
- The antibiotic class characterized by excellent coverage against Gram-negative infections, including pseudomonas, but lacking reliable Gram-positive or anaerobic coverage is Monobactam.
Cell Wall Inhibitors
- The antibiotic class that inhibits cell wall synthesis by binding the terminal molecule of the peptidoglycan is beta-lactam antibiotics.
- Carbapenems primarily target the cell wall of Gram-negative bacteria.
Antibiotic Resistance
- Beta-lactamases are a concern in antibiotic resistance because they can hydrolyze beta-lactam antibiotics.
Antibiotic Characteristics
- Aminopenicillins do not reliably cover Pseudomonas infections.
- Penicillin G is not reliably effective against anaerobic infections.
- The unique characteristic of Penicillin G administration is its short half-life.
- Penicillin V reliably covers streptococcus and staphylococcus infections.
- Cephalosporins are active against Gram-positive and Gram-negative organisms.
Specific Antibiotics
- Metronidazole is used to treat C.difficile infections and is associated with a high risk of pseudomembranous colitis.
- Vancomycin is used to treat MRSA bacteremia and is characterized by its activity against Gram-positive organisms and anaerobes.
- Daptomycin is active against Gram-positive agents, including MRSA, and cannot be used for lung infections.
- Polymyxins have detergent-like activity, destroying the cell membrane by direct chemical interaction with lipopolysaccharides (LPS), and are only active against Gram-negative agents.
Topical Antibiotics
- Cell wall inhibitors like Polymyxins are mainly used topically for wounds and burn injuries.
Antibiotic Toxicity
- Chloramphenicol is associated with the unique toxicity known as 'Gray baby syndrome'.
Test your knowledge on cephalosporins, carbapenems, and monobactams antibiotics. Learn which antibiotics cover pseudomonas, MRSA, contain a beta-lactam ring, resist degradation by beta-lactamases, and are combined with enzyme inhibitors.
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