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Questions and Answers
Measles Virus Receptors CD46/MCP is expressed on ______ nucleated cells
Measles Virus Receptors CD46/MCP is expressed on ______ nucleated cells
all
Measles Virus Receptors CD150/SLAM is expressed on a subset of ______ cells
Measles Virus Receptors CD150/SLAM is expressed on a subset of ______ cells
immune
Enveloped viruses can do direct plasma membrane fusion o endocytosis vs non ______
Enveloped viruses can do direct plasma membrane fusion o endocytosis vs non ______
pores
Pox use ______ o trick into thinking its an apoptic body
Pox use ______ o trick into thinking its an apoptic body
Measles Virus Receptors Nectin4/PVRL4 is normally restricted to ______ in humans
Measles Virus Receptors Nectin4/PVRL4 is normally restricted to ______ in humans
Measles Virus exits via ______ epithelium
Measles Virus exits via ______ epithelium
[Blank] is the first discovered viral receptor for influenza
[Blank] is the first discovered viral receptor for influenza
There are three different receptors for the viral entry into the host cell: 1. [Blank] 2. MCP/CD46 o compliment binding protein 3. PVRL4/Nectin 4
There are three different receptors for the viral entry into the host cell: 1. [Blank] 2. MCP/CD46 o compliment binding protein 3. PVRL4/Nectin 4
The measles virus exits the cell by fusing into ________.
The measles virus exits the cell by fusing into ________.
Nectin 4 is present between ________ in the respiratory tract.
Nectin 4 is present between ________ in the respiratory tract.
The virus within T, B, and dendritic cells will bind to ________ and gain entry into epithelial cells.
The virus within T, B, and dendritic cells will bind to ________ and gain entry into epithelial cells.
SLAM and ________ are the two receptors used by wild-type MeV to infect and exit its human host.
SLAM and ________ are the two receptors used by wild-type MeV to infect and exit its human host.
Using a pseudotype virus has the advantage of allowing researchers to work on the SARS cov2 research in a ______ facility.
Using a pseudotype virus has the advantage of allowing researchers to work on the SARS cov2 research in a ______ facility.
One limitation of using a pseudotype virus is that you don't know the role of other ______ proteins.
One limitation of using a pseudotype virus is that you don't know the role of other ______ proteins.
In the study, the spike protein of SARS cov2 demonstrated ______ activity.
In the study, the spike protein of SARS cov2 demonstrated ______ activity.
When expressing the spike protein of SARS cov2 in cells, the researchers observed cleavage into S1 and S2, providing ______ evidence of cleavage.
When expressing the spike protein of SARS cov2 in cells, the researchers observed cleavage into S1 and S2, providing ______ evidence of cleavage.
Which receptor does SARS-CoV-2 bind to?
Which receptor does SARS-CoV-2 bind to?
What is the function of the fusion peptide proximal region (FPPR) in SARS-CoV-2 membrane fusion?
What is the function of the fusion peptide proximal region (FPPR) in SARS-CoV-2 membrane fusion?
What is the post-fusion structure of S2 responsible for?
What is the post-fusion structure of S2 responsible for?
What is the purpose of the second cleavage in SARS-CoV-2 membrane fusion?
What is the purpose of the second cleavage in SARS-CoV-2 membrane fusion?
mRNA vaccines have a ______ locked state of spike in their surface so that they don’t have - Lock spike in its pre-fusion state so that when it is expressed, it is only existing in the S1/S2 complex --. There is no post fusion spike that is being made Only post fusion S2 on the surface of the vriions
mRNA vaccines have a ______ locked state of spike in their surface so that they don’t have - Lock spike in its pre-fusion state so that when it is expressed, it is only existing in the S1/S2 complex --. There is no post fusion spike that is being made Only post fusion S2 on the surface of the vriions
The S1 and S2 exists in the trimer form and are recognized by ______
The S1 and S2 exists in the trimer form and are recognized by ______
There is already a prefusion cleavage between S1 and S2 by ______ but TMPRSS2 can also cleave but it predominantly cleaves at the S2 prime site and the S2 prime site is important for S1 fall off and expose major conformational changes in S2 exposes the fusion peptide which allows the virus to engage with target cellular protein. Fusion of viral post membrane and release of contents into the cytosol
There is already a prefusion cleavage between S1 and S2 by ______ but TMPRSS2 can also cleave but it predominantly cleaves at the S2 prime site and the S2 prime site is important for S1 fall off and expose major conformational changes in S2 exposes the fusion peptide which allows the virus to engage with target cellular protein. Fusion of viral post membrane and release of contents into the cytosol
This study showed that ______ is important for cells that are TMPRSS2 + for SARS-CoV-2 to enter the cell, but TMPRSS2 - cells can't fuse through the cell membrane and inhibiting ______ results in no infection. Inhibition of cathepsin B had no major affect on the ability of SARS-CoV-2 to enter the cell
This study showed that ______ is important for cells that are TMPRSS2 + for SARS-CoV-2 to enter the cell, but TMPRSS2 - cells can't fuse through the cell membrane and inhibiting ______ results in no infection. Inhibition of cathepsin B had no major affect on the ability of SARS-CoV-2 to enter the cell
Cellular barriers to virus entry include the _______ and the _______.
Cellular barriers to virus entry include the _______ and the _______.
The major stages of virus entry include 1. ________, 2. ________, and 3. ________.
The major stages of virus entry include 1. ________, 2. ________, and 3. ________.
Enveloped viruses can undergo direct plasma membrane fusion or enter the cell through ________.
Enveloped viruses can undergo direct plasma membrane fusion or enter the cell through ________.
Which of the following is NOT a cellular receptor used by viruses?
Which of the following is NOT a cellular receptor used by viruses?
What is the primary function of the fusion protein (F) in the Measles Virus?
What is the primary function of the fusion protein (F) in the Measles Virus?
Which of the following is true about the Measles Virus life cycle?
Which of the following is true about the Measles Virus life cycle?
What are some characteristics of a useful cellular receptor for a virus?
What are some characteristics of a useful cellular receptor for a virus?
Which one of these is a cellular barrier that viruses encounter while trying to get into the cell?
Which one of these is a cellular barrier that viruses encounter while trying to get into the cell?
Which one of these is a major stage of virus entry?
Which one of these is a major stage of virus entry?
Which one of these is an example of direct fusion at the plasma membrane?
Which one of these is an example of direct fusion at the plasma membrane?
Which receptor is used by the measles virus to infect immune cells?
Which receptor is used by the measles virus to infect immune cells?
Which receptor is upregulated in cancer cells and can potentially replicate in cancer cells?
Which receptor is upregulated in cancer cells and can potentially replicate in cancer cells?
Which receptor allows the measles virus to exit the host through the respiratory epithelium?
Which receptor allows the measles virus to exit the host through the respiratory epithelium?
Which co-receptor does the measles virus use to bind to dendritic cells in the respiratory tract?
Which co-receptor does the measles virus use to bind to dendritic cells in the respiratory tract?
Which enzyme is responsible for the prefusion cleavage between S1 and S2 in SARS-CoV-2?
Which enzyme is responsible for the prefusion cleavage between S1 and S2 in SARS-CoV-2?
Which enzyme predominantly cleaves at the S2 prime site in SARS-CoV-2?
Which enzyme predominantly cleaves at the S2 prime site in SARS-CoV-2?
Which enzyme is important for cells that are TMPRSS2 positive to enter the cell?
Which enzyme is important for cells that are TMPRSS2 positive to enter the cell?
Which enzyme inhibition results in no infection in TMPRSS2 negative cells?
Which enzyme inhibition results in no infection in TMPRSS2 negative cells?
Which of the following is the correct equation for finding the area of a rectangle?
Which of the following is the correct equation for finding the area of a rectangle?
Which of the following is the correct equation for finding the circumference of a circle?
Which of the following is the correct equation for finding the circumference of a circle?
Which of the following is the correct equation for finding the slope of a line given two points?
Which of the following is the correct equation for finding the slope of a line given two points?
Which of the following is the correct equation for finding the volume of a cylinder?
Which of the following is the correct equation for finding the volume of a cylinder?
Which of the following is the correct equation for finding the area of a triangle?
Which of the following is the correct equation for finding the area of a triangle?
Which of the following is the correct equation for finding the area of a rectangle?
Which of the following is the correct equation for finding the area of a rectangle?
Which of the following is the correct formula for finding the circumference of a circle?
Which of the following is the correct formula for finding the circumference of a circle?
Which of the following is the correct equation for finding the slope of a line?
Which of the following is the correct equation for finding the slope of a line?
Which of the following is the correct formula for finding the volume of a sphere?
Which of the following is the correct formula for finding the volume of a sphere?
Which of the following is the correct equation for finding the distance between two points in a coordinate plane?
Which of the following is the correct equation for finding the distance between two points in a coordinate plane?
Which receptor does the measles virus use to infect immune cells?
Which receptor does the measles virus use to infect immune cells?
What is the correct equation for finding the volume of a cylinder?
What is the correct equation for finding the volume of a cylinder?
Which enzyme inhibition results in no infection in TMPRSS2 negative cells?
Which enzyme inhibition results in no infection in TMPRSS2 negative cells?
Measles virus exits via which epithelium?
Measles virus exits via which epithelium?
Which receptor does the measles virus bind to for exit from the cell or the host?
Which receptor does the measles virus bind to for exit from the cell or the host?
What is the role of TMPRSS2 in SARS-CoV-2 entry into cells?
What is the role of TMPRSS2 in SARS-CoV-2 entry into cells?
How many true attachment proteins are present on the surface of SARS-CoV-2?
How many true attachment proteins are present on the surface of SARS-CoV-2?
Which receptor is used by wild-type MeV to infect and exit its human host?
Which receptor is used by wild-type MeV to infect and exit its human host?
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