Cellular Signaling and Extracellular Matrix Quiz

<p>They can promote cell migration and differentiation. (B)</p> Signup and view all the answers

<p>By promoting the synthesis of cellular proteins. (B)</p> Signup and view all the answers

<p>The ECM is primarily composed of water and lipids. (B)</p> Signup and view all the answers

<p>Endocrine signaling (A)</p> Signup and view all the answers

<p>Directly killing bacteria (B)</p> Signup and view all the answers

<p>Vascular endothelial growth factor (VEGF) (B)</p> Signup and view all the answers

<p>Release of pro-inflammatory cytokines (A)</p> Signup and view all the answers

<p>Macrophages (C)</p> Signup and view all the answers

<p>Synthesis of new extracellular matrix components (C)</p> Signup and view all the answers

<p>Synthesis of collagen and other ECM components (B)</p> Signup and view all the answers

<p>Increased vascularization (A)</p> Signup and view all the answers

<p>Presence of chronic infection (D)</p> Signup and view all the answers

<p>Collagen deposition (B)</p> Signup and view all the answers

<p>To provide nutrients and oxygen to the growing tissue (D)</p> Signup and view all the answers

<p>Collagen synthesis (C)</p> Signup and view all the answers

<p>It contributes to the edematous appearance of the healing tissue (B)</p> Signup and view all the answers

<p>Dense collagen fibers (A)</p> Signup and view all the answers

<p>To synthesize collagen and other extracellular matrix components (A)</p> Signup and view all the answers

<p>They are degraded, leaving few vessels in the mature scar (D)</p> Signup and view all the answers

<p>Angiogenesis occurs before re-epithelialization (C)</p> Signup and view all the answers

<p>Fibroblasts are responsible for the synthesis and deposition of the extracellular matrix, including collagen and elastin. (D)</p> Signup and view all the answers

<p>The ECM provides structural support for blood vessels and aids in the regulation of growth factors essential for their integrity. (C)</p> Signup and view all the answers

<p>Fibroblast Growth Factor (FGF) (C)</p> Signup and view all the answers

<p>Oxygen is essential for the hydroxylation of proline and lysine residues in collagen, which is critical for proper bonding and structure. (C)</p> Signup and view all the answers

<p>The cells are undergoing apoptosis, a programmed cell death process, as they are no longer needed. (C)</p> Signup and view all the answers

<p>Healing by first intention is characterized by a clean wound with minimal tissue loss, while second intention involves a larger, more complex wound with significant tissue loss. (D)</p> Signup and view all the answers

<p>Myofibroblasts contribute to the contraction of the wound, drawing the edges closer together. (C)</p> Signup and view all the answers

<p>An excessive production of collagen fibers during the remodeling phase. (C)</p> Signup and view all the answers

<p>Stable cells (B)</p> Signup and view all the answers

<p>They are limited in their ability to regenerate in response to injury. (B)</p> Signup and view all the answers

<p>Proliferate (B)</p> Signup and view all the answers

<p>Cardiac muscle (C)</p> Signup and view all the answers

<p>Regeneration, involving the proliferation of uninjured cells. (C)</p> Signup and view all the answers

<p>Labile cells contain a pool of stem cells. (D)</p> Signup and view all the answers

<p>Healing always involves both regeneration and repair. (D)</p> Signup and view all the answers

<p>Formation of scar tissue as a result of connective tissue deposition. (C)</p> Signup and view all the answers

<p>Excessive UV light exposure (D)</p> Signup and view all the answers

<p>Hypertrophic scars remain within the wound boundaries, while keloids extend beyond the original wound. (C)</p> Signup and view all the answers

<p>Increased pressure on the wound site, often due to abdominal distention. (C)</p> Signup and view all the answers

<p>Osteomyelitis (A)</p> Signup and view all the answers

<p>Marjolin's ulcer (D)</p> Signup and view all the answers

<p>UV light exposure (C)</p> Signup and view all the answers

<p>A patient with a healthy weight undergoing a routine skin graft procedure. (D)</p> Signup and view all the answers

<p>A balanced diet with sufficient protein, vitamin C, zinc, and magnesium promotes efficient wound healing. (D)</p> Signup and view all the answers

The body's response to injury for restoring normal structure and function.

Process by which some tissues replace damaged components and return to a normal state.

Healing that occurs through proliferation of connective tissue, leading to fibrosis and scarring.

Cells that continuously divide and can easily regenerate after injury.

Cells that can multiply in response to stimuli but lose ability post-adolescence.

Cells that lose the ability to proliferate around birth and cannot regenerate.

Substances that are crucial for tissue repair and regeneration.

Sequence of events leading to the restoration of normal tissue after injury.

Extracellular matrix supports cells and regulates tissue structure.

Include hemostasis, inflammation, proliferation, and remodeling.

Immediate response with blood vessel constriction and clot formation.

Begins after hemostasis; influx of immune cells to prevent infection.

Proinflammatory signals like IL-1, IL-6, and TNF-α are released.

Rebuilding of the wound with new tissue, collagen, and extracellular matrix.

Immune cells that clear debris and support healing in inflammation.

The process by which a cell splits into two or more daughter cells.

Cell responds to signals it releases itself.

Signaling between adjacent cells, influencing their behavior.

Long-distance signaling via hormones carried in the blood.

A network of proteins surrounding cells vital for tissue structure and repair.

Proteins like collagen and elastin provide strength and elasticity to tissues.

A thin layer of ECM associated with epithelial and mesenchymal cells.

The process where a wound reduces in size as new tissues form.

Recovery of a wound involving migration and proliferation of keratinocytes.

The formation of new blood vessels from existing ones, vital for healing.

Tissue that forms in wounds, characterized by a pink, soft appearance and new capillaries.

Cells that proliferate in wounds to produce collagen and support tissue repair.

The process of connective tissue formation which provides strength to the wound area.

Vascular Endothelial Growth Factor; a key molecule that stimulates angiogenesis.

Extracellular Matrix formation; a network that supports cells in tissues.

A chemical process that modifies proline and lysine for collagen formation.

The process of rearranging and modifying the extracellular matrix over time.

Cell signaling molecules that influence inflammation and tissue healing.

Modified fibroblasts that help contract wounds during healing.

Raised scars that occur from excessive tissue formation at the wound site.

A type of wound healing with minimal tissue loss and clean edges.

Local and systemic influences that impact how wounds heal.

Elements at the wound site that can enhance or hinder healing, like infection and blood supply.

Overall bodily conditions affecting healing, such as age and nutrition.

Scar tissue that grows beyond its original boundaries and does not regress.

Excessive granulation tissue that protrudes and hinders healing.

Wound rupture often occurring after abdominal surgery due to pressure.

Bone infection that can occur in chronic wounds, such as diabetic ulcers.