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What process generates O2 and organic molecules used in cellular respiration?
What process generates O2 and organic molecules used in cellular respiration?
Fermentation occurs in the presence of oxygen.
Fermentation occurs in the presence of oxygen.
False
What organic molecules are primarily used in cellular respiration to regenerate ATP?
What organic molecules are primarily used in cellular respiration to regenerate ATP?
Sugars
Aerobic respiration consumes organic molecules and ________.
Aerobic respiration consumes organic molecules and ________.
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Which process provides energy to cells by consuming organic molecules and other compounds aside from oxygen?
Which process provides energy to cells by consuming organic molecules and other compounds aside from oxygen?
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Match the following processes with their descriptions:
Match the following processes with their descriptions:
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Cells use ATP to power most cellular work.
Cells use ATP to power most cellular work.
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What flows into an ecosystem as sunlight?
What flows into an ecosystem as sunlight?
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What is the primary fuel molecule that is often used to trace cellular respiration?
What is the primary fuel molecule that is often used to trace cellular respiration?
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Aerobic respiration does not involve oxygen.
Aerobic respiration does not involve oxygen.
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What happens to glucose during cellular respiration?
What happens to glucose during cellular respiration?
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During cellular respiration, glucose is oxidized, and __________ is reduced.
During cellular respiration, glucose is oxidized, and __________ is reduced.
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Which coenzyme acts as an electron acceptor during cellular respiration?
Which coenzyme acts as an electron acceptor during cellular respiration?
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Match the following terms with their definitions:
Match the following terms with their definitions:
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The chemical reaction for cellular respiration can be summarized as __________ + __________ → __________ + __________ + Energy.
The chemical reaction for cellular respiration can be summarized as __________ + __________ → __________ + __________ + Energy.
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What is the primary product of glycolysis?
What is the primary product of glycolysis?
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What does OIL in the context of oxidation-reduction reactions stand for?
What does OIL in the context of oxidation-reduction reactions stand for?
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What is produced during the oxidation of pyruvate to acetyl CoA?
What is produced during the oxidation of pyruvate to acetyl CoA?
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Glycolysis requires oxygen to proceed.
Glycolysis requires oxygen to proceed.
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The citric acid cycle produces ATP directly from the breakdown of pyruvate.
The citric acid cycle produces ATP directly from the breakdown of pyruvate.
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What is produced during the energy payoff phase of glycolysis?
What is produced during the energy payoff phase of glycolysis?
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The maximum ATP yield from one molecule of glucose through aerobic respiration is about ______ ATP.
The maximum ATP yield from one molecule of glucose through aerobic respiration is about ______ ATP.
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What is the primary role of acetyl CoA in cellular respiration?
What is the primary role of acetyl CoA in cellular respiration?
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Match the following processes with their corresponding products:
Match the following processes with their corresponding products:
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The citric acid cycle is also known as the _____ cycle.
The citric acid cycle is also known as the _____ cycle.
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Which molecule directly enters the Citric Acid Cycle after pyruvate is oxidized?
Which molecule directly enters the Citric Acid Cycle after pyruvate is oxidized?
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Match the following products of the citric acid cycle with their quantities per turn:
Match the following products of the citric acid cycle with their quantities per turn:
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The oxidation of glucose is completed in the mitochondrion of eukaryotic cells.
The oxidation of glucose is completed in the mitochondrion of eukaryotic cells.
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Which of the following molecules carries electrons to the electron transport chain?
Which of the following molecules carries electrons to the electron transport chain?
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What are the two electron carriers mentioned that transport electrons to the electron transport chain?
What are the two electron carriers mentioned that transport electrons to the electron transport chain?
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The citric acid cycle consists of nine steps, each facilitated by a specialized enzyme.
The citric acid cycle consists of nine steps, each facilitated by a specialized enzyme.
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How many turns does the citric acid cycle make per glucose molecule?
How many turns does the citric acid cycle make per glucose molecule?
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What is the net ATP yield from glycolysis?
What is the net ATP yield from glycolysis?
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Obligate anaerobes can perform aerobic respiration.
Obligate anaerobes can perform aerobic respiration.
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What is the main final electron acceptor in fermentation?
What is the main final electron acceptor in fermentation?
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Cellular respiration produces ______ ATP per glucose molecule.
Cellular respiration produces ______ ATP per glucose molecule.
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Match the type of fermentation with its product:
Match the type of fermentation with its product:
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Which of the following statements is true about facultative anaerobes?
Which of the following statements is true about facultative anaerobes?
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Glycolysis is a process that evolved after the advent of significant atmospheric oxygen.
Glycolysis is a process that evolved after the advent of significant atmospheric oxygen.
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What are the two alternative catabolic routes that pyruvate can take in a facultative anaerobe?
What are the two alternative catabolic routes that pyruvate can take in a facultative anaerobe?
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What is the primary input that initiates the citric acid cycle?
What is the primary input that initiates the citric acid cycle?
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NADH is produced during the conversion of isocitrate to alpha-ketoglutarate.
NADH is produced during the conversion of isocitrate to alpha-ketoglutarate.
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What are the two electron carriers mainly involved in ATP synthesis after glycolysis?
What are the two electron carriers mainly involved in ATP synthesis after glycolysis?
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The compound _____ is regenerated at the end of the citric acid cycle.
The compound _____ is regenerated at the end of the citric acid cycle.
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Match the enzymes with their respective reactions in the citric acid cycle:
Match the enzymes with their respective reactions in the citric acid cycle:
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Which molecules donate electrons to the electron transport chain after the citric acid cycle?
Which molecules donate electrons to the electron transport chain after the citric acid cycle?
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ATP is generated during the conversion of Succinate to Fumarate.
ATP is generated during the conversion of Succinate to Fumarate.
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Where does oxidative phosphorylation primarily occur?
Where does oxidative phosphorylation primarily occur?
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The process of chemiosmosis couples electron transport to _____ synthesis.
The process of chemiosmosis couples electron transport to _____ synthesis.
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Match the following compounds with their roles in the citric acid cycle:
Match the following compounds with their roles in the citric acid cycle:
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What is one of the main outputs of the citric acid cycle?
What is one of the main outputs of the citric acid cycle?
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Isocitrate is the first molecule formed in the citric acid cycle.
Isocitrate is the first molecule formed in the citric acid cycle.
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Identify one key difference between NADH and FADH2 in terms of energy production.
Identify one key difference between NADH and FADH2 in terms of energy production.
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During the citric acid cycle, _____ acid is formed from the hydration of fumarate.
During the citric acid cycle, _____ acid is formed from the hydration of fumarate.
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What is produced when succinyl CoA is converted to succinate?
What is produced when succinyl CoA is converted to succinate?
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Study Notes
Cellular Respiration and Fermentation Overview
- Living cells require energy from external sources.
- Organisms obtain energy by consuming plants or other organisms that consume plants.
- Energy flows into ecosystems as sunlight and leaves as heat.
- Photosynthesis produces oxygen and organic molecules, which are used in cellular respiration.
- Cells utilize chemical energy stored in organic molecules to regenerate ATP, the energy currency of cells, to power cellular work.
Catabolic Pathways and ATP Production
- Fermentation is a partial sugar breakdown occurring without oxygen.
- Aerobic respiration utilizes organic molecules and oxygen to produce ATP.
- Anaerobic respiration is similar to aerobic respiration, but utilizes compounds other than oxygen.
- Cellular respiration incorporates both aerobic and anaerobic respiration, but typically refers to aerobic respiration.
- Glucose is often used to track cellular respiration— a molecule of C6H12O6 + 6 O2 yields 6 CO2 + 6 H2O + Energy (ATP + heat).
The Principle of Redox
- Redox reactions involve electron transfer between reactants.
- Oxidation occurs when a substance loses electrons.
- Reduction occurs when a substance gains electrons; this reduces the amount of positive charge. -OIL RIG: Oxidation Is Loss, Reduction Is Gain helps to remember.
Oxidation of Organic Fuel Molecules During Cellular Respiration
- During cellular respiration, the fuel (e.g., glucose) gets oxidized, and O2 is reduced.
- The formula for glucose oxidation by cellular respiration is C6H12O6 + 602 → 6 CO2 + 6 H2O + Energy.
Stepwise Energy Harvest via NAD+ and the Electron Transport Chain
- Glucose and organic molecules are broken down step-by-step in cellular respiration.
- Electrons from organic compounds are initially transferred to NAD+ (a coenzyme).
- NAD+ acts as an oxidizing agent in cellular respiration
- NADH (reduced form of NAD+) contains stored chemical energy that helps synthesize ATP.
- NADH transports electrons to the electron transport chain.
- The electron transport chain releases energy from electrons step-by-step, unlike an uncontrolled reaction, to regenerate ATP.
- O2 pulls electrons down the electron transport chain in an energy-yielding manner.
The Stages of Cellular Respiration: A Preview
- Glucose breakdown involves three stages:
- Glycolysis
- The Citric Acid Cycle
- Oxidative phosphorylation
Glycolysis
- Glycolysis breaks down glucose into two pyruvate molecules.
- Glycolysis occurs whether or not oxygen is present.
- Glycolysis occurs in the cytosol and yields a net gain of 2 ATP per glucose molecule.
- Also produces 2 NADH and 2 Pyruvates.
Transition Reaction Linking Glycolysis to the Citric Acid Cycle
- Before entering the citric acid cycle, pyruvate gets oxidized to acetyl CoA.
- This conversion of pyruvate to acetyl CoA links glycolysis to the citric acid cycle.
- Acetyl CoA has an important role in linking glycolysis and citric acid cycle.
The Citric Acid Cycle
- The citric acid cycle (Krebs cycle) completes the breakdown of pyruvate.
- The cycle further oxidizes organic fuel derived from pyruvate, generating ATP, NADH, and FADH2.
- The cycle has eight steps catalyzed by specific enzymes.
- The cycle also releases carbon dioxide.
- The amount of ATP per turn of the cycle is 1, for two turns it becomes 2 ATP
- There are also two NADH, and two FADH2 per turn, in total it will amount to 6 NADH and 2 FADH2, per glucose.
Oxidative Phosphorylation
- This stage accounts for most of the ATP production in cellular respiration.
- It involves electron transport and chemiosmosis.
- Electron carriers, like NADH and FADH2, contribute electrons to the electron transport chain.
- The electron transport chain pumps protons across the inner mitochondrial membrane, creating a proton gradient.
- Chemiosmosis uses this gradient to generate ATP through ATP synthase.
- The exact amount of ATP produced (typically 30-32 per glucose) varies depending on cellular conditions.
Fermentation
- Fermentation enables cells to produce ATP without oxygen.
- It is an anaerobic process that involves glycolysis coupled with reactions regenerating NAD+.
- Two common types of fermentation are lactic acid fermentation and alcohol fermentation.
Lactic Acid Fermentation
- Pyruvate is reduced to lactic acid in lactic acid fermentation.
- This process regenerates NAD+ for glycolysis to continue.
- Lactic acid fermentation is used by some bacteria and fungi to make cheese and yogurt.
- It is also used by human muscle cells when oxygen is scarce during intense exercise which causes lactic acid buildup in muscles.
Alcoholic Fermentation
- Pyruvate is converted into ethanol in two steps, releasing CO2, during alcoholic fermentation.
- Alcoholic fermentation regenerates NAD+ for glycolysis to continue.
- Yeast utilizes alcoholic fermentation in brewing, winemaking, and baking due to the production of ethanol and CO2.
Comparing Fermentation and Aerobic Respiration
- Glycolysis is the initial step in both fermentation and aerobic respiration.
- NAD+ is the electron acceptor in both cases.
- Alcoholic and lactic acid fermentations use a different final electron acceptor unlike aerobic respiration, which uses oxygen.
- Aerobic respiration produces significantly more ATP compared to fermentation.
Other Metabolic Pathways Involved in Glycolysis and the Citric Acid Cycle
- Glycolysis and the citric acid cycle also incorporate molecules from other macromolecules like proteins, carbohydrates, and fats.
Regulation of Cellular Respiration
- Feedback mechanisms control cellular respiration's rate.
- Enzyme concentrations control the flow of metabolic intermediates through cellular respiration.
Calculating ATP
- The actual number of ATP molecules produced during cellular respiration can range from 30-32 rather than 36.
Cellular Respiration in Prokaryotes vs. Eukaryotes
- The location of cellular respiration differs between prokaryotes and eukaryotes, which affects ATP yield. In prokaryotes it all happens in the cytosol, whereas it is separated in the mitochondria in eukaryotes making variations in the amount of ATP produced possible.
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Test your knowledge on cellular respiration processes with this quiz. Understand the mechanisms behind ATP regeneration, the role of oxygen, and the involved organic molecules. Perfect for students studying biology or life sciences.