Podcast
Questions and Answers
What is the role of hepcidin in the regulation of iron absorption?
What is the role of hepcidin in the regulation of iron absorption?
- Stimulates iron transport in the blood
- Promotes iron absorption from the intestines into the blood
- Inhibits iron absorption from the intestines into the blood (correct)
- Facilitates iron storage in the liver
Which section of Lippincott Illustrated Reviews in Biochemistry covers the topic of heme degradation?
Which section of Lippincott Illustrated Reviews in Biochemistry covers the topic of heme degradation?
- Chapter 21, section on Heme degradation (correct)
- Chapter 16, section on Hemoglobin synthesis
- Chapter 28, sections on folate and vitamin B12
- Chapter 29, section III.B on Iron
What are the main carriers involved in intestinal iron absorption?
What are the main carriers involved in intestinal iron absorption?
- Haptoglobin and hepcidin
- Ferritin and transferrin
- DMT1 and ferroportin (correct)
- Hemoglobin and myoglobin
What is the function of iron in the human body?
What is the function of iron in the human body?
What is the epidemiology of hemochromatosis?
What is the epidemiology of hemochromatosis?
Which section of Lippincott Illustrated Reviews in Biochemistry addresses the functions of iron, the way it is bound to proteins, and its distribution in tissues?
Which section of Lippincott Illustrated Reviews in Biochemistry addresses the functions of iron, the way it is bound to proteins, and its distribution in tissues?
Which form of iron is absorbed more efficiently?
Which form of iron is absorbed more efficiently?
What is the major regulatory hormone for iron absorption and use?
What is the major regulatory hormone for iron absorption and use?
Which enzyme cooperates with membrane transporters to change the oxidation state of iron?
Which enzyme cooperates with membrane transporters to change the oxidation state of iron?
Where is excess dietary iron stored in the body?
Where is excess dietary iron stored in the body?
What facilitates the uptake of iron from the intestine?
What facilitates the uptake of iron from the intestine?
Which protein is the main carrier of iron in circulation?
Which protein is the main carrier of iron in circulation?
What is measured as the total iron binding capacity by transferrin?
What is measured as the total iron binding capacity by transferrin?
How do cells acquire iron through receptor-mediated endocytosis?
How do cells acquire iron through receptor-mediated endocytosis?
What is the role of heme and iron-containing proteins in individual cells?
What is the role of heme and iron-containing proteins in individual cells?
What is the main form of stored iron in cells?
What is the main form of stored iron in cells?
Where is dietary iron generally liberated as?
Where is dietary iron generally liberated as?
Which component facilitates the uptake of non-heme iron in the duodenum?
Which component facilitates the uptake of non-heme iron in the duodenum?
Which type of anemia is characterized by bone marrow failure?
Which type of anemia is characterized by bone marrow failure?
What is the daily iron allowance for menstruating women in the US?
What is the daily iron allowance for menstruating women in the US?
Which condition causes an inability to use iron for heme synthesis?
Which condition causes an inability to use iron for heme synthesis?
What is the effect of the C282Y mutation in the HFE gene on hepcidin secretion?
What is the effect of the C282Y mutation in the HFE gene on hepcidin secretion?
What is the treatment for hemochromatosis?
What is the treatment for hemochromatosis?
What does serum ferritin measure in the body?
What does serum ferritin measure in the body?
Which laboratory measurement is a good indicator of iron deficiency or overload?
Which laboratory measurement is a good indicator of iron deficiency or overload?
Total Iron Binding Capacity (TIBC) essentially measures what in the blood?
Total Iron Binding Capacity (TIBC) essentially measures what in the blood?
Serum ferritin is used to confirm which two conditions related to iron?
Serum ferritin is used to confirm which two conditions related to iron?
What happens to senescent erythrocytes in the body?
What happens to senescent erythrocytes in the body?
What is the final product of urobilinogen metabolism?
What is the final product of urobilinogen metabolism?
How does the body excrete bilirubin from the liver?
How does the body excrete bilirubin from the liver?
In which organelle can iron be translocated for incorporation into heme and iron-sulfur clusters?
In which organelle can iron be translocated for incorporation into heme and iron-sulfur clusters?
What is the major storage form of iron in cells?
What is the major storage form of iron in cells?
What is the normal range for blood ferritin in men?
What is the normal range for blood ferritin in men?
What is the function of heavy chains in the ferritin complex?
What is the function of heavy chains in the ferritin complex?
What happens in iron deficiency at the cellular level?
What happens in iron deficiency at the cellular level?
What is the net effect of hepcidin on circulating iron and dietary absorption?
What is the net effect of hepcidin on circulating iron and dietary absorption?
What is the role of hepcidin in the body during infections and cancers?
What is the role of hepcidin in the body during infections and cancers?
Where does the blockage of ferroportin occur due to hepcidin action?
Where does the blockage of ferroportin occur due to hepcidin action?
What happens to iron from worn-out RBCs?
What happens to iron from worn-out RBCs?
What is the daily balance of iron absorption and loss in adults?
What is the daily balance of iron absorption and loss in adults?
Which of the following is the primary source of heme for degradation?
Which of the following is the primary source of heme for degradation?
What is the final product of heme degradation?
What is the final product of heme degradation?
What is the normal serum level of bilirubin?
What is the normal serum level of bilirubin?
Which condition can cause jaundice due to increased bilirubin levels?
Which condition can cause jaundice due to increased bilirubin levels?
What are the dietary sources of Vitamin B9 (Folate)?
What are the dietary sources of Vitamin B9 (Folate)?
Which population is at risk of folate deficiency?
Which population is at risk of folate deficiency?
What are the symptoms of megaloblastic anemia?
What are the symptoms of megaloblastic anemia?
What is the principal role of folate in the body?
What is the principal role of folate in the body?
Which enzyme uses B12 as a cofactor in the synthesis of methionine from homocysteine?
Which enzyme uses B12 as a cofactor in the synthesis of methionine from homocysteine?
What is the net reaction catalyzed by methionine synthase?
What is the net reaction catalyzed by methionine synthase?
What is the consequence of B12 deficiency on folate metabolism?
What is the consequence of B12 deficiency on folate metabolism?
Which of the following is a role of iron in metabolism?
Which of the following is a role of iron in metabolism?
What is the main form of stored iron in cells?
What is the main form of stored iron in cells?
Which of the following is a symptom of iron deficiency anemia?
Which of the following is a symptom of iron deficiency anemia?
What is the recommended daily intake of iron for men and women?
What is the recommended daily intake of iron for men and women?
What facilitates the absorption of non-heme iron in the intestine?
What facilitates the absorption of non-heme iron in the intestine?
Which condition can lead to iron overload?
Which condition can lead to iron overload?
What is the main role of folate in erythropoiesis?
What is the main role of folate in erythropoiesis?
What condition can result from folate deficiency?
What condition can result from folate deficiency?
What are some dietary sources of folate?
What are some dietary sources of folate?
What is the main transporter for cobalamin in the blood?
What is the main transporter for cobalamin in the blood?