7.3 Cellular Immune Response Part 3
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Questions and Answers

What is the role of CD4+ T cells in CD8+ T cell differentiation during latent viral infections, organ transplants, and tumors?

  • CD4+ T cell help is required (correct)
  • CD8+ T cells provide help to CD4+ T cells
  • CD8+ T cell differentiation is independent of CD4+ T cells
  • CD4+ T cell help is not critical

Which cytokine is important for the survival of memory CD8+ T cells?

  • IL-21
  • IL-2
  • IL-12
  • IL-15 (correct)

What is the role of CD8+ cytotoxic T cells in eliminating intracellular microbes?

  • They phagocytose infected cells
  • They kill infected cells (correct)
  • They secrete antibodies
  • They promote inflammation

What is the principal ligand for the LFA-1 integrin in the formation of an immunological synapse between CTLs and target cells?

<p>ICAM-1 (A)</p> Signup and view all the answers

Which cytokine promotes proliferation and differentiation of CD8+ T cells into effector CTLs and memory CTLs?

<p>IL-2 (C)</p> Signup and view all the answers

Which of the following is not an effector function of CD8+ cytotoxic T cells?

<p>Phagocytosing infected cells (A)</p> Signup and view all the answers

What is the main function of CD8+ T cells?

<p>Killing cells infected with viruses in the cytosol (C)</p> Signup and view all the answers

What type of transcription factors control the differentiation of CD8+ T cells into Cytotoxic T Lymphocytes?

<p>T-bet and Eomesodermin (A)</p> Signup and view all the answers

Which type of antigens can stimulate CD8+ T cells?

<p>Cytosol-derived antigens (D)</p> Signup and view all the answers

What is the role of specialized subsets of APCs, such as CD8+ DCs, in the immune response?

<p>They cross-present antigens to CD8+ T cells (C)</p> Signup and view all the answers

What is the nature of the machinery acquired by CD8+ T cells during their differentiation into Cytotoxic T Lymphocytes?

<p>They acquire modified lysosomes containing perforin and granzymes (B)</p> Signup and view all the answers

Which of the following is NOT a function of CD8+ T cells?

<p>Production of antibodies (D)</p> Signup and view all the answers

What is required for target cells to be efficiently recognized by CTLs?

<p>Bind to ICAM-1 ligand (C)</p> Signup and view all the answers

Which cytokine is responsible for stimulating the differentiation of naive CD8+ T cells into effector CTLs?

<p>IL-12 (C)</p> Signup and view all the answers

In weak innate immune reactions, what type of T cell help is required for CD8+ T cell differentiation?

<p>CD4+ T cell help (C)</p> Signup and view all the answers

Which of the following is an effector function of CD8+ cytotoxic T cells?

<p>Elimination of infected cells (A)</p> Signup and view all the answers

What is the role of IL-15 in the context of CD8+ T cells?

<p>Important for memory T cell survival (B)</p> Signup and view all the answers

Which molecule is the principal ligand for the LFA-1 integrin during the formation of an immunological synapse?

<p>ICAM-1 (A)</p> Signup and view all the answers

Which transcription factor is NOT involved in controlling the differentiation of CD8+ T cells into Cytotoxic T Lymphocytes?

<p>Foxp3 (A)</p> Signup and view all the answers

Which of the following antigens cannot directly stimulate CD8+ T cells?

<p>Externally derived bacterial antigens (A)</p> Signup and view all the answers

Which type of cells can cross-present antigens to CD8+ T cells?

<p>Specialized subsets of APCs, such as CD8+ DCs (B)</p> Signup and view all the answers

Which of the following is NOT an effector function of CD8+ T cells?

<p>Antibody production (D)</p> Signup and view all the answers

Which cytokine is important for the survival of memory CD8+ T cells?

<p>IL-2 (A)</p> Signup and view all the answers

Which ligand is the principal ligand for the LFA-1 integrin in the formation of an immunological synapse between CTLs and target cells?

<p>ICAM-1 (B)</p> Signup and view all the answers

Flashcards

Role of CD4+ T cells in CD8+ T cell differentiation

CD4+ T cells are crucial for the differentiation of CD8+ T cells into effector and memory cells during situations like latent viral infections, organ transplants, and tumors.

Cytokine for memory CD8+ T cell survival

IL-15 is a key cytokine for maintaining the survival of memory CD8+ T cells.

Role of CD8+ T cells in killing infected cells

CD8+ cytotoxic T cells are responsible for directly killing cells infected with intracellular microbes.

Ligand for LFA-1 integrin in immunological synapse

ICAM-1 is the primary ligand for the LFA-1 integrin, which is crucial for the immunological synapse formation between CTLs and target cells.

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Cytokine for CD8+ T cell proliferation and differentiation

IL-2 is essential for the proliferation and differentiation of CD8+ T cells into effector CTLs and memory CTLs.

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Effector Function of CD8+ cytotoxic T cells

CD8+ cytotoxic T cells primarily kill infected cells.

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Main Function of CD8+ T cells

The primary function of CD8+ T cells is to kill cells infected with viruses residing in the cytosol.

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Transcription factors for CD8+ T cell differentiation

T-bet and Eomesodermin are transcription factors crucial for the differentiation of CD8+ T cells into Cytotoxic T Lymphocytes.

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Antigens stimulating CD8+ T cells

CD8+ T cells are stimulated by antigens derived from the cytosol.

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Role of specialized APCs in CD8+ T cell response

Specialized APCs, such as CD8+ DCs, play a crucial role in presenting antigens to CD8+ T cells, initiating their response.

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Machinery acquired by CD8+ T cells during differentiation

During differentiation into CTLs, CD8+ T cells acquire modified lysosomes containing perforin and granzymes, which are essential for their killing function.

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Function of CD8+ T cells

CD8+ T cells don't produce antibodies; they are directly involved in killing infected cells.

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Requirement for efficient CTL recognition of target cells

Effective recognition of target cells by CTLs requires binding to the ICAM-1 ligand.

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Cytokine for CD8+ T cell differentiation into effector CTLs

IL-12 plays a crucial role in stimulating the differentiation of naive CD8+ T cells into effector CTLs.

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T cell help for CD8+ T cell differentiation in weak innate immune responses

In situations with weak innate immune responses, CD4+ T cell help is essential for the differentiation of CD8+ T cells.

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Effector function of CD8+ cytotoxic T cells

Elimination of infected cells is a key effector function of CD8+ cytotoxic T cells.

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Role of IL-15 in CD8+ T cells

IL-15 is crucial for the survival of memory CD8+ T cells.

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Ligand for LFA-1 integrin in immunological synapse

ICAM-1 is the primary ligand for the LFA-1 integrin during the formation of an immunological synapse.

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Transcription factor not involved in CD8+ T cell differentiation

Foxp3 is not involved in the differentiation of CD8+ T cells; it's associated with regulatory T cells.

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Antigens that cannot directly stimulate CD8+ T cells

Externally derived bacterial antigens cannot directly stimulate CD8+ T cells; they rely on specialized APCs.

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Cells that can cross-present antigens to CD8+ T cells

Specialized subsets of APCs, such as CD8+ DCs, can cross-present antigens to CD8+ T cells.

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Function of CD8+ T cells

CD8+ T cells are primarily involved in killing infected cells, not in producing antibodies.

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Cytokine important for memory CD8+ T cell survival

IL-2 is important for the survival of memory CD8+ T cells.

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Ligand for LFA-1 integrin in immunological synapse

ICAM-1 is the primary ligand for the LFA-1 integrin in the formation of an immunological synapse between CTLs and target cells.

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