24 Questions
What is the role of CD4+ T cells in CD8+ T cell differentiation during latent viral infections, organ transplants, and tumors?
CD4+ T cell help is required
Which cytokine is important for the survival of memory CD8+ T cells?
IL-15
What is the role of CD8+ cytotoxic T cells in eliminating intracellular microbes?
They kill infected cells
What is the principal ligand for the LFA-1 integrin in the formation of an immunological synapse between CTLs and target cells?
ICAM-1
Which cytokine promotes proliferation and differentiation of CD8+ T cells into effector CTLs and memory CTLs?
IL-2
Which of the following is not an effector function of CD8+ cytotoxic T cells?
Phagocytosing infected cells
What is the main function of CD8+ T cells?
Killing cells infected with viruses in the cytosol
What type of transcription factors control the differentiation of CD8+ T cells into Cytotoxic T Lymphocytes?
T-bet and Eomesodermin
Which type of antigens can stimulate CD8+ T cells?
Cytosol-derived antigens
What is the role of specialized subsets of APCs, such as CD8+ DCs, in the immune response?
They cross-present antigens to CD8+ T cells
What is the nature of the machinery acquired by CD8+ T cells during their differentiation into Cytotoxic T Lymphocytes?
They acquire modified lysosomes containing perforin and granzymes
Which of the following is NOT a function of CD8+ T cells?
Production of antibodies
What is required for target cells to be efficiently recognized by CTLs?
Bind to ICAM-1 ligand
Which cytokine is responsible for stimulating the differentiation of naive CD8+ T cells into effector CTLs?
IL-12
In weak innate immune reactions, what type of T cell help is required for CD8+ T cell differentiation?
CD4+ T cell help
Which of the following is an effector function of CD8+ cytotoxic T cells?
Elimination of infected cells
What is the role of IL-15 in the context of CD8+ T cells?
Important for memory T cell survival
Which molecule is the principal ligand for the LFA-1 integrin during the formation of an immunological synapse?
ICAM-1
Which transcription factor is NOT involved in controlling the differentiation of CD8+ T cells into Cytotoxic T Lymphocytes?
Foxp3
Which of the following antigens cannot directly stimulate CD8+ T cells?
Externally derived bacterial antigens
Which type of cells can cross-present antigens to CD8+ T cells?
Specialized subsets of APCs, such as CD8+ DCs
Which of the following is NOT an effector function of CD8+ T cells?
Antibody production
Which cytokine is important for the survival of memory CD8+ T cells?
IL-2
Which ligand is the principal ligand for the LFA-1 integrin in the formation of an immunological synapse between CTLs and target cells?
ICAM-1
Learn about the role of CD8+ T cells in the immune response, including their function in eliminating viruses. Understand the importance of microbicidal mechanisms in killing viruses and how the immune system targets viruses in the cytosol.
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