Cellular Immune Response III: CD8+ T Cells Differentiation and Functions
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Questions and Answers

What is the role of CD4+ T cells in CD8+ T cell differentiation during latent viral infections, organ transplants, and tumors?

  • CD4+ T cell help is required (correct)
  • CD8+ T cells provide help to CD4+ T cells
  • CD8+ T cell differentiation is independent of CD4+ T cells
  • CD4+ T cell help is not critical

    • Which cytokine is important for the survival of memory CD8+ T cells?

  • IL-21
  • IL-2
  • IL-12
  • IL-15 (correct)

    • What is the role of CD8+ cytotoxic T cells in eliminating intracellular microbes?

  • They phagocytose infected cells
  • They kill infected cells (correct)
  • They secrete antibodies
  • They promote inflammation

    • What is the principal ligand for the LFA-1 integrin in the formation of an immunological synapse between CTLs and target cells?

    <p>ICAM-1</p> Signup and view all the answers

    Which cytokine promotes proliferation and differentiation of CD8+ T cells into effector CTLs and memory CTLs?

    <p>IL-2</p> Signup and view all the answers

    Which of the following is not an effector function of CD8+ cytotoxic T cells?

    <p>Phagocytosing infected cells</p> Signup and view all the answers

    What is the main function of CD8+ T cells?

    <p>Killing cells infected with viruses in the cytosol</p> Signup and view all the answers

    What type of transcription factors control the differentiation of CD8+ T cells into Cytotoxic T Lymphocytes?

    <p>T-bet and Eomesodermin</p> Signup and view all the answers

    Which type of antigens can stimulate CD8+ T cells?

    <p>Cytosol-derived antigens</p> Signup and view all the answers

    What is the role of specialized subsets of APCs, such as CD8+ DCs, in the immune response?

    <p>They cross-present antigens to CD8+ T cells</p> Signup and view all the answers

    What is the nature of the machinery acquired by CD8+ T cells during their differentiation into Cytotoxic T Lymphocytes?

    <p>They acquire modified lysosomes containing perforin and granzymes</p> Signup and view all the answers

    Which of the following is NOT a function of CD8+ T cells?

    <p>Production of antibodies</p> Signup and view all the answers

    What is required for target cells to be efficiently recognized by CTLs?

    <p>Bind to ICAM-1 ligand</p> Signup and view all the answers

    Which cytokine is responsible for stimulating the differentiation of naive CD8+ T cells into effector CTLs?

    <p>IL-12</p> Signup and view all the answers

    In weak innate immune reactions, what type of T cell help is required for CD8+ T cell differentiation?

    <p>CD4+ T cell help</p> Signup and view all the answers

    Which of the following is an effector function of CD8+ cytotoxic T cells?

    <p>Elimination of infected cells</p> Signup and view all the answers

    What is the role of IL-15 in the context of CD8+ T cells?

    <p>Important for memory T cell survival</p> Signup and view all the answers

    Which molecule is the principal ligand for the LFA-1 integrin during the formation of an immunological synapse?

    <p>ICAM-1</p> Signup and view all the answers

    Which transcription factor is NOT involved in controlling the differentiation of CD8+ T cells into Cytotoxic T Lymphocytes?

    <p>Foxp3</p> Signup and view all the answers

    Which of the following antigens cannot directly stimulate CD8+ T cells?

    <p>Externally derived bacterial antigens</p> Signup and view all the answers

    Which type of cells can cross-present antigens to CD8+ T cells?

    <p>Specialized subsets of APCs, such as CD8+ DCs</p> Signup and view all the answers

    Which of the following is NOT an effector function of CD8+ T cells?

    <p>Antibody production</p> Signup and view all the answers

    Which cytokine is important for the survival of memory CD8+ T cells?

    <p>IL-2</p> Signup and view all the answers

    Which ligand is the principal ligand for the LFA-1 integrin in the formation of an immunological synapse between CTLs and target cells?

    <p>ICAM-1</p> Signup and view all the answers

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