Cellular Immune Response II Differentiation and Functions of CD4 Effector T Cells
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Questions and Answers

What is the primary role of IFN-γ for TH1 cells?

  • Stimulates expression of molecules enhancing antigen presentation
  • Promotes IgG2a subclass switching in B cells
  • Amplifies the TH1 subset and inhibits TH2 and TH17 development
  • Activates macrophages to kill phagocytosed microbes (correct)

    • How does IFN-γ affect the development of other T cell subsets?

  • Enhances TH2 subset development while suppressing TH1 cells
  • Promotes TH2 and TH17 cell proliferation
  • Amplifies the TH1 subset and inhibits TH2 and TH17 differentiation (correct)
  • Has no influence on the differentiation of other T cell subsets

    • Which cells play a central role in phagocyte-independent defense mediated by the TH2 subset?

  • Neutrophils
  • Eosinophils and mast cells (correct)
  • Macrophages
  • Dendritic cells

    • What is one of the therapeutic uses of IFN-γ in veterinary medicine?

    <p>Treatment of atopic dermatitis with recombinant IFN-γ</p> Signup and view all the answers

    How does IFN-γ influence B cells regarding immunoglobulin subclass switching?

    <p>Promotes IgG2a subclass switching and inhibits IgE switching</p> Signup and view all the answers

    Which interactions activate macrophages through contact-mediated signals for TH1 cells?

    <p>CD40L-CD40 interactions</p> Signup and view all the answers

    What is responsible for the differentiation of TH2 cells?

    <p>IL-4</p> Signup and view all the answers

    Which cytokines are the main ones produced by TH2 cells?

    <p>IL-4, IL-5, and IL-13</p> Signup and view all the answers

    What is the function of TH2 cells in combating infections?

    <p>Producing IgE</p> Signup and view all the answers

    Which subset is responsible for inducing neutrophil-rich inflammation?

    <p>TH17 subset</p> Signup and view all the answers

    What initiates the differentiation of TH17 cells?

    <p>IL-1 and IL-6</p> Signup and view all the answers

    What is a function of the TH17 cells in combating microbes?

    <p>Producing antimicrobial substances</p> Signup and view all the answers

    Which cytokines are involved in the development of TH1 cells?

    <p>IL-12 and IFN-γ</p> Signup and view all the answers

    What is the primary function of TH1 cells?

    <p>Activating macrophages to ingest and destroy microbes</p> Signup and view all the answers

    Which transcription factors are involved in TH1 differentiation?

    <p>T-bet, STAT1, and STAT4</p> Signup and view all the answers

    Which CD4+ T cell subset is the major effector T cell population in phagocyte-mediated host defense?

    <p>TH1</p> Signup and view all the answers

    Which subset of CD4+ T cells is induced by microbes that are ingested by phagocytes?

    <p>TH1</p> Signup and view all the answers

    Which CD4+ T cell subset is involved in antibody production?

    <p>Follicular helper T cells</p> Signup and view all the answers

    How does IFN-γ affect the development of TH2 and TH17 cells?

    <p>Inhibits the development of both TH2 and TH17 cells</p> Signup and view all the answers

    What is the role of IFN-γ in antigen presentation?

    <p>Stimulates the expression of molecules that enhance antigen presentation</p> Signup and view all the answers

    Which cells play a central role in phagocyte-independent defense mediated by the TH2 subset?

    <p>Eosinophils and mast cells</p> Signup and view all the answers

    What is the therapeutic use of IFN-γ in veterinary medicine mentioned in the text?

    <p>Treatment of atopic dermatitis</p> Signup and view all the answers

    How do TH1 cells activate macrophages?

    <p>Through contact-mediated signals delivered by CD40L-CD40 interactions and IFN-γ</p> Signup and view all the answers

    What is the effect of IFN-γ on B cells regarding immunoglobulin subclass switching?

    <p>Promotes switching to IgG2a and inhibits switching to IgE</p> Signup and view all the answers

    What is the main role of TH2 cells?

    <p>Stimulating the production of IgE and eosinophils</p> Signup and view all the answers

    Which cytokines are predominantly associated with TH17 cells?

    <p>IL-1, IL-6, IL-23</p> Signup and view all the answers

    What is the function of TH2 cells in combating infections?

    <p>Stimulating alternative macrophage activation</p> Signup and view all the answers

    Which T cell subset is responsible for inducing neutrophil-rich inflammation?

    <p>TH17 Cells</p> Signup and view all the answers

    What initiates the differentiation of TH17 cells?

    <p>Pro-inflammatory cytokines produced in response to bacteria and fungi</p> Signup and view all the answers

    What is a key function of TH2 cells?

    <p>Stimulating the production of IgE and eosinophils</p> Signup and view all the answers

    What is the initial activation site for CD4+ T cells in response to infections?

    <p>Lymphoid organs</p> Signup and view all the answers

    Which cytokine is primarily involved in activating macrophages for TH1 cells?

    <p>IFN-γ</p> Signup and view all the answers

    Which CD4+ T cell subset is primarily responsible for inducing neutrophil-rich inflammation?

    <p>TH17</p> Signup and view all the answers

    Which cells play a central role in phagocyte-independent defense mediated by the TH2 subset?

    <p>Eosinophils</p> Signup and view all the answers

    Which transcription factors are involved in TH1 differentiation?

    <p>T-bet, STAT1, and STAT4</p> Signup and view all the answers

    Which CD4+ T cell subset is involved in activating macrophages to ingest and destroy microbes?

    <p>TH1</p> Signup and view all the answers

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