Cellular Adaptations and Cardiac Pathologies

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Questions and Answers

Which of the following best describes the hemodynamic response to aortic insufficiency (AI)?

  • Decreased preload, leading to increased contractility.
  • Decreased afterload, leading to decreased ventricular end-diastolic pressure.
  • Increased preload, leading to ventricular volume overload. (correct)
  • Increased afterload, leading to decreased stroke volume.

What is the significance of identifying an eccentric diastolic closure line on M-mode echocardiography in the context of aortic valve pathology?

  • It confirms the presence of a bicuspid aortic valve.
  • It suggests the presence of aortic valve regurgitation. (correct)
  • It is a normal finding and of no clinical significance.
  • It indicates the severity of aortic valve stenosis.

Which of the following best describes the utility of performing a Dobutamine stress echo in the evaluation of aortic stenosis?

  • To evaluate for inducible myocardial ischemia.
  • To identify the presence of a bicuspid aortic valve.
  • To measure pulmonary artery pressure.
  • To assess the severity of aortic stenosis in patients with low ejection fraction. (correct)

A patient is diagnosed with Takotsubo cardiomyopathy (TTC). Angiography reveals no coronary artery disease. Which of the following is the most likely trigger for this condition?

<p>Emotional stress. (D)</p> Signup and view all the answers

Which of the following best explains the 'pressure cascade' or 'domino effect' in the context of aortic stenosis?

<p>The sequential increase in chamber pressures from left ventricle to left atrium. (A)</p> Signup and view all the answers

A patient with known aortic stenosis presents with pulsus parvus et tardus. What does this clinical finding suggest about their condition?

<p>Severe aortic stenosis with reduced stroke volume (C)</p> Signup and view all the answers

What is the primary advantage of surgical aortic valve replacement (SAVR) compared to transcatheter aortic valve replacement (TAVR) in younger patients?

<p>Established long-term durability data (B)</p> Signup and view all the answers

Which echocardiographic method is most suitable for assessing AS Doppler measurements in patients with irregular heart rhythms, such as atrial fibrillation?

<p>Averaging multiple measurements over several cardiac cycles. (A)</p> Signup and view all the answers

A patient with dilated cardiomyopathy (DCM) has a left ventricular ejection fraction (LVEF) of less than 40%. Which of the following is a potential long-term consequence of this condition?

<p>Increased risk of sudden death secondary to ventricular arrhythmia. (C)</p> Signup and view all the answers

Which of the following is the correct method for calculating aortic valve area (AVA) using the continuity equation?

<p>$AVA = (LVOT\ Velocity imes LVOT\ Area) / Aortic\ Valve\ Velocity$ (D)</p> Signup and view all the answers

Flashcards

Atrophy

Decrease in cell size

Hypertrophy

Increase in cell size

Hyperplasia

Increase in cell number

Metaplasia

Change in cell type

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Dysplasia

Disordered cell growth

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Apoptosis

Programmed cell death

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Stenosis

Narrowing of a valve

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Regurgitation

Valve not closing properly

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Aortic Valve Stenosis

Narrowing of aortic valve

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Angiotensin Converting Enzyme (ACE) - "pril"

An ACE inhibitor medication

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Study Notes

  • Atrophy: The wasting away or decrease in size of a body part, tissue, or organ.
  • Hypertrophy: The enlargement of an organ or tissue from the increase in size of its cells.
  • Hyperplasia: The enlargement of an organ or tissue caused by an increase in the reproduction rate of its cells.
  • Metaplasia: The abnormal change in the nature of a tissue.
  • Dysplasia: The presence of cells of an abnormal type within a tissue, which may signify a stage preceding the development of cancer.
  • Apoptosis: The process of programmed cell death.
  • Left Ventricular Hypertrophy: Thickening of the heart's left ventricle.
  • Stenosis: The abnormal narrowing of a passage in the body.
  • Ventricular Torsion & Twisting: The wringing motion of the ventricles during the cardiac cycle.
  • Regurgitation: The backward flowing of blood.
  • Aortic Valve Stenosis: Narrowing of the aortic valve opening.
  • Degenerative: Resulting from or characterized by degeneration.
  • Congenital: Present from birth.
  • Rheumatic Fever: An inflammatory disease that can develop as a complication of inadequately treated strep throat or scarlet fever.
  • Bicuspid Aortic Valve: A type of aortic valve that only has two leaflets, instead of the normal three.
  • Unicuspid Aortic Valve: A rare congenital heart defect in which the aortic valve has only one leaflet.
  • Quadracuspid Aortic Valve: A rare congenital heart defect in which the aortic valve has four leaflets.
  • Raphe: A ridge or seam-like structure.
  • Acquired bicuspid aortic valve: Bicuspid aortic valve that develops later in life.
  • Aortic Stenosis as seen on M-Mode echocardiography is a diagnostic tool using motion mode.
  • Eccentric diastolic closure line: An abnormal M-mode finding in aortic stenosis.
  • Raphe Types: Categorized as Type O, Type I, or Type II, describing the extent and location of the raphe on bicuspid aortic valves.
  • Symptoms related to aortic stenosis
  • Aortic Stenosis Clinical Findings/Presentation
  • Complications of Aortic Stenosis: Potential adverse outcomes resulting from the condition.
  • Chamber Pressures resulting from Aortic Stenosis
  • Pressure Cascade/Domino Effect due to AS
  • Crescendo-Decrescendo: The characteristic shape of the systolic murmur in aortic stenosis.
  • Pulsus Parvus et Tardus: A weak and delayed arterial pulse associated with aortic stenosis.
  • Complimentary testing/modalities for Aortic Stenosis
  • Cardiac Catheterization: An invasive diagnostic procedure used to assess the severity of aortic stenosis.
  • Gorlin Formula: Used to calculate aortic valve area.
  • M-Mode in AS, appearance on M-Mode imaging.
  • Wigger's Diagram in AS: A graphical representation of the cardiac cycle in aortic stenosis.
  • Systolic "doming": The upward bowing of the aortic valve during systole, seen in aortic stenosis.
  • Post stenotic dilatation: Enlargement of the aorta beyond the point of stenosis.
  • Left atrial enlargement can be caused by Aortic Stenosis
  • Aortic Stenosis in late course, leading to decreased LV systolic function
  • AS - Peak Velocity: The highest velocity of blood flow through the stenotic aortic valve.
  • AS - Maximum Instantaneous Pressure Gradient: The peak difference in pressure across the aortic valve.
  • AS - Mean Transvalvular Pressure Gradient: Average pressure difference across the aortic valve during systole.
  • Aortic Valve Area (AVA): The calculated area of the aortic valve opening.
  • Aortic Stenosis Velocity Ratio
  • Bernoulli Principle: Used to estimate pressure gradients across the aortic valve.
  • Aortic Stenosis can cause aortic insufficiency/regurgitation
  • Doppler in Aortic Stenosis versus Mitral Regurgitation
  • Continuity Equation: Formula used to calculate valve area based on flow velocities.
  • Common Errors in Flow Angle
  • AS Doppler Measurement in Irregular Rhythm(s)
  • Dimensionless Measurements
  • Aortic Valve Prolapse
  • Aortic Stenosis
  • Aortic Valve Perforation
  • Aortic Annular Dilatation/Aortic Root Dilatation
  • Aortic Insufficiency (AI) / Aortic Regurgitation (AR)
  • Hemodynamic LV Response to AI
  • AI Pressure Half-Time (P1/2t)
  • Descending Aorta - Diastolic Reversal = blood flows in opposite direction during diastole in the descending aorta
  • Abdominal Aorta - Diastolic Reversal = blood flows in opposite direction during diastole in the abdominal aorta
  • Color Doppler: extent, occupancy, and aliasing properties
  • AI Spectral Doppler: Spectral Broadening strength
  • AI - Proximal Isovelocity Surface Area (PISA)
  • AI - Vena Contracta
  • Emphasis on pathology relating to heart conditions and disease.
  • Echo/ultrasound usage in descriptive language
  • Pedoff probe windows/positions
  • Aortic stenosis with low ejection fraction
  • Dobutamine/Dobutamine stress echo: Stress test using dobutamine to assess aortic stenosis.
  • False positive for Aortic Stenosis
  • Angiotensin Converting Enzyme (ACE) Inhibitors which typically end in "pril"
  • Beta Blockers typically end in "olol"
  • Selective versus non-selective beta blockers
  • Preload: The amount of ventricular stretch at the end of diastole.
  • Afterload: The resistance the left ventricle must overcome to circulate blood.
  • Prosthetic valves use in valve replacement surgery
  • Mechanical Valve Types
  • Bioprosthetic Valves
  • Allograft or Homograft: A tissue graft from a donor of the same species.
  • Porcine Heterograft: A xenograft from a pig.
  • Bovine Heterograft: A xenograft from a cow.
  • Aortic Stenosis Symptoms include
  • Mechanical Versus Bioprosthetic Longevity
  • Surgical Aortic Valve Replacement (SAVR): Traditional open-heart surgery for valve replacement.
  • Transcatheter Aortic Valve Replacement (TAVR): Minimally invasive procedure for valve replacement.
  • Valve-in-Valve TAVR: Placement of a new valve inside a failed TAVR valve.
  • Normal mean valve gradient for prosthetic valve
  • Cardiomyopathies: Diseases of the heart muscle.
  • Dilated Cardiomyopathy (DCM): Enlargement and weakening of the left ventricle.
  • Genetic CM: Cardiomyopathy caused by genetic factors.
  • Acquired CM: Cardiomyopathy caused by external factors. -LVEF <40%: Indicates reduced left ventricular ejection fraction, indicative of heart failure.

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