Cellular Adaptation Reactions Definitions Quiz
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Questions and Answers

Define cellular adaptation.

Reversible functional and structural response to more severe physiologic stresses and some pathologic stimuli resulting in new but altered steady state.

What is hyperplasia?

Increase in the number of cells.

Explain hypertrophy.

Increase in the size of cells or organ.

Describe atrophy.

<p>Decrease in size and metabolic activity.</p> Signup and view all the answers

What is metaplasia?

<p>Replacement of adult cells by another adult cell type.</p> Signup and view all the answers

Explain physiologic hyperplasia.

<p>Increased functional capacity of tissue for periodic requirements.</p> Signup and view all the answers

Give an example of pathologic hyperplasia.

<p>Endometrial hyperplasia induced by hormone dysbalance.</p> Signup and view all the answers

What characterizes hypertrophy?

<p>Enlargement of cells leading to increased organ size.</p> Signup and view all the answers

What are the organs responsible for blood oxygenation and possible compensation mechanisms?

<p>Cardiovascular system, Respiratory system, Erythrocytes, Tissue metabolism</p> Signup and view all the answers

What is the fastest compensatory mechanism for respiratory acidosis?

<p>Hyperventilation</p> Signup and view all the answers

How does hyperventilation relate to hypoxia?

<p>Hypoxic stimulation leads to hyperventilation in an attempt to correct hypoxia at the expense of CO2 loss.</p> Signup and view all the answers

What can tachycardia lead to in terms of myocardial oxygen need?

<p>Tachycardia raises myocardial need for oxygen, potentially leading to myocardial hypoxic injury.</p> Signup and view all the answers

In what condition does the Renin-angiotensin-aldosterone system get activated?

<p>Hypovolemia, for example, after blood loss.</p> Signup and view all the answers

What is the consequence of increased erythropoietin synthesis in the kidneys?

<p>Secondary polycythemia</p> Signup and view all the answers

What does the oxyhemoglobin dissociation curve describe?

<p>The relationship between the saturation of hemoglobin and the partial pressure of arterial oxygen.</p> Signup and view all the answers

What effect does hyperventilation have on blood pH?

<p>Hyperventilation can lead to respiratory alkalosis.</p> Signup and view all the answers

Define cyanosis.

<p>Cyanosis is characterized by a bluish discoloration of the skin or mucous membranes.</p> Signup and view all the answers

What level of deoxygenated hemoglobin in the arteries is associated with central cyanosis?

<p>Above 50 g/L.</p> Signup and view all the answers

In what conditions might cyanosis not be clinically evident in a patient with severe anemia?

<p>Due to the inability to obtain a high enough level of reduced hemoglobin.</p> Signup and view all the answers

What is the difference between central and peripheral cyanosis?

<p>Central cyanosis is related to arterial blood and reduced hemoglobin levels, while peripheral cyanosis is seen in extremities with slower blood flow.</p> Signup and view all the answers

What is a symptom of hypoxia that is subjective and involves difficulty breathing?

<p>Dyspnea.</p> Signup and view all the answers

Name a congenital heart pathology associated with central cyanosis.

<p>Tetralogy of Fallot.</p> Signup and view all the answers

What are some symptoms caused by compensatory mechanisms in response to hypoxia?

<p>Fatigue, malaise, anxiety, confusion, insomnia.</p> Signup and view all the answers

What is another term for peripheral cyanosis seen in the upper and lower extremities?

<p>Acral cyanosis.</p> Signup and view all the answers

What are the morphological signs of acute pulmonary congestion with pulmonary edema?

<p>Tissues are red, full with fluid; veins and alveolar capillaries engorged with blood; erythrocyte extravasation may occur.</p> Signup and view all the answers

How does interstitial pulmonary edema differ from alveolar pulmonary edema?

<p>Interstitial pulmonary edema may occur as fluid is pushed from the capillaries into the alveolar septae, while alveolar pulmonary edema may occur as fluid goes into alveoli from the alveolar septae.</p> Signup and view all the answers

What are the morphological signs of chronic pulmonary congestion?

<p>Veins and capillaries are full-filled with blood; numerous intraalveolar haemosiderinladed macrophages are present; interstitial fibrosis can be observed.</p> Signup and view all the answers

What is the cause of blood congestion in the liver according to the scheme?

<p>Right-sided heart failure.</p> Signup and view all the answers

What are the symptoms associated with blood congestion caused by right-sided heart failure?

<p>Dilated jugular veins and ascites.</p> Signup and view all the answers

Describe the norm of peripheral edema according to the blood circulation scheme.

<p>Peripheral edema.</p> Signup and view all the answers

What may occur in acute blood congestion in the lungs with pulmonary edema?

<p>Erythrocyte extravasation.</p> Signup and view all the answers

What is the role of haemosiderinladed macrophages in chronic pulmonary congestion?

<p>They are numerous intraalveolar cells known as s.heart-failure cells.</p> Signup and view all the answers

What is the significance of methemoglobinemia in relation to oxygen uptake?

<p>metHb is unable to accept oxygen like the typical 2+ oxidation state, causing a leftward shift in the oxygen-hemoglobin dissociation curve.</p> Signup and view all the answers

How does carbon monoxide affect the oxygen-hemoglobin dissociation curve?

<p>Carbon monoxide binds hemoglobin ~250 times more rapidly than oxygen, reducing available binding spots and shifting the curve leftward.</p> Signup and view all the answers

What structural difference does fetal hemoglobin have compared to adult hemoglobin?

<p>Fetal hemoglobin is adapted to have a higher affinity for oxygen.</p> Signup and view all the answers

What is the biological significance of inflammation?

<p>Inflammation serves a protective role by defending against injurious agents and removing damaged tissue.</p> Signup and view all the answers

Give examples of conditions or diseases associated with inflammation.

<p>Examples include pneumonia, ARVI, gut infections, hepatitis, and appendicitis.</p> Signup and view all the answers

How is inflammation connected to repair, regeneration, and healing?

<p>Inflammation plays a role in the processes of repair, regeneration, and healing.</p> Signup and view all the answers

What are the two opposing aspects of the biological meaning of inflammation?

<p>Inflammation can be protective (defending against tissue injury) or harmful (contributing to diseases like rheumatoid arthritis).</p> Signup and view all the answers

What are some consequences of inflammation when it becomes harmful?

<p>Harmful inflammation can lead to conditions like rheumatoid arthritis, atherosclerosis, and life-threatening hypersensitivity reactions.</p> Signup and view all the answers

What is the hallmark sign of dystrophic calcification?

<p>Abnormal deposition of calcium salts</p> Signup and view all the answers

Which condition is NOT associated with metastatic calcification?

<p>Decreased parathyroid hormone (PTH) level</p> Signup and view all the answers

What organ is commonly affected by metastatic calcification?

<p>Lung</p> Signup and view all the answers

What is the primary cause of cholestasis?

<p>Accumulation of lipochrome</p> Signup and view all the answers

In cellular aging, what physiological changes are observed in almost all organs and systems?

<p>Physiologic and structural alterations</p> Signup and view all the answers

What distinguishes metastatic calcification from dystrophic calcification?

<p>Occurs in basic pH tissues</p> Signup and view all the answers

What is the main cause of histotoxic hypoxia?

<p>Defect in cellular usage of oxygen</p> Signup and view all the answers

Which condition is characterized by cyanosis caused by cessation of aerobic cell metabolism?

<p>Cyanide poisoning</p> Signup and view all the answers

How does cyanide poisoning affect cellular metabolism?

<p>Blocks Krebs cycle enzymes</p> Signup and view all the answers

Which substance is known to block Krebs cycle enzymes?

<p>Tetrachloromethane</p> Signup and view all the answers

In circulatory hypoxia, what initial blood parameter may be normal despite decreased oxygen delivery?

<p>$PaO_2$</p> Signup and view all the answers

What leads to mixed hypoxia that includes both circulatory and respiratory components?

<p>Shock</p> Signup and view all the answers

What is the basis of pathogenesis for Disseminated Intravascular Coagulation (DIC) syndrome?

<p>Formation of many tiny, microscopic fibrin thrombi in microcirculation vessels</p> Signup and view all the answers

In which conditions can arterial thrombosis occur?

<p>Atherosclerosis and deep vein thrombosis</p> Signup and view all the answers

What condition can lead to the formation of emboli from thrombi in the heart, aorta, and arteries causing brain or kidney damage?

<p>Disseminated Intravascular Coagulation (DIC) syndrome</p> Signup and view all the answers

Which clinical condition can be characterized by pain, edema with possible collaterals, and PATE?

<p>Deep vein thrombosis</p> Signup and view all the answers

What is a potential consequence of clot formation in the heart in cases of bacterial endocarditis?

<p>Formation of emboli leading to brain damage</p> Signup and view all the answers

What are the main morphological components of acute inflammation?

<p>Exudation of fluid and plasma proteins, oedema, reaction/emigration of neutrophils</p> Signup and view all the answers

What causes increased vascular permeability in acute inflammation?

<p>Formation of intercellular endothelial gaps</p> Signup and view all the answers

Which component is mainly observed in Helicobacter pylori gastritis?

<p>Cellular infiltrate</p> Signup and view all the answers

What are the characteristics of chronic inflammation compared to acute inflammation?

<p>Long-lasting and reactions of lymphocytes/macrophages</p> Signup and view all the answers

What are the etiological factors of acute inflammation?

<p>Microbial toxins and tissue necrosis</p> Signup and view all the answers

What characterizes chronic inflammation with regards to leukocyte presence?

<p>Accumulation of lymphocytes and macrophages</p> Signup and view all the answers

What is the pH range for transudate?

<p>6.5-8.0</p> Signup and view all the answers

Which type of exudate involves the highest content of proteins?

<p>Purulent</p> Signup and view all the answers

What is the primary factor that causes leukocytes emigration to the focus of inflammation?

<p>Positive haemotaxis</p> Signup and view all the answers

According to the Law on leukocytes emigration, what is the sequence in which different types of leukocytes migrate to the focus of inflammation?

<p>Granulocytes → monocyte → lymphocyte</p> Signup and view all the answers

What does 'Restitutio incompleta' refer to in terms of local inflammation?

<p>Replacement of specific tissues by connective tissues and partial renewal of function</p> Signup and view all the answers

What is the mechanism provided by which leukocyte emigration is facilitated during inflammation?

<p>Flow of exudates</p> Signup and view all the answers

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