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Questions and Answers
What occurs during the promotion phase of cancer development?
Which term describes the spread of cancer cells to other parts of the body?
What is the role of the TNM system in cancer assessment?
Which of the following describes the characteristics of malignant cells?
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Which of the following methods is NOT a way that cancer spreads?
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What does the 'M' in the TNM classification system represent?
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Which of the following is classified as 'Tis' in the TNM classification?
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What clinical manifestation is characterized by weight loss and profound weakness?
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Which option is NOT a method for cancer detection?
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Which classification indicates the presence of distant metastasis?
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In the TNM system, what does 'Nx' signify?
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Which treatment option is designed to relieve symptoms rather than cure the disease?
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Which one of the following is a characteristic of paraneoplastic syndromes?
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What is the primary focus of cellular adaptation in response to adverse stimuli?
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Which of the following is a common cause of hypoxia?
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Which term best describes the process involving changes in cells to prevent disease?
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What are genetic defects known to affect in cellular metabolism?
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Which of the following agents can lead to cellular adaptation?
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In the context of neoplasia, what distinguishes a benign tumor from a malignant tumor?
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What is one of the key mechanisms of inheritance discussed in neoplasia?
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Which adaptive change is most likely to occur due to traumatic injury?
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What type of cells are responsible for forming the structures of the body?
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Which of the following statements is true regarding meiosis?
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What distinguishes autosomal dominant disorders from autosomal recessive disorders?
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Congenital conditions can be attributed to which of the following?
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What is the primary result of mitosis?
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Which of the following correctly describes sex-linked inheritance?
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Which of the following is an example of an autosomal recessive disorder?
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Which mechanism causes changes in gene function that can lead to genetic disorders?
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What is Marfan Syndrome primarily characterized by?
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Which symptom is NOT associated with Marfan Syndrome?
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What is the primary cause of Phenylketonuria (PKU)?
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What effect does Hemophilia A have on the body?
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Which of the following describes Turner’s syndrome?
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Which disorder is associated with the presence of a third copy of chromosome 21?
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What is a common characteristic of neoplasms?
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What distinguishes a tumor from a neoplasm?
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Study Notes
Adaptive Changes and Causes of Cellular Adaptation
- Cells can undergo adaptive changes to cope with various stimuli, ensuring self-repair and regeneration to prevent disease.
- Common causes of cellular adaptation include physical agents (trauma, burns), chemical agents (poisons, drugs), microorganisms (bacteria, viruses), hypoxia (inadequate oxygen), genetic defects, nutritional imbalances, and immunologic reactions (hypersensitivity).
Genetic Control of Cell Function and Inheritance
- Cells are categorized based on function: somatic cells (forming body structures) and germ cells (forming reproductive cells).
- Somatic cells reproduce through mitosis, creating two identical cells with 23 pairs of chromosomes.
- Germ cells reproduce via meiosis, resulting in four cells with 23 chromosomes each; these are gametes (ova or sperm).
- During conception, a sperm and ovum merge, forming a new cell with 23 pairs of chromosomes.
Genetic Disorders
- Genetic disorders arise from alterations in gene function or chromosomal structure, potentially presenting at birth or later in life.
Congenital Disorders
- Congenital conditions are present at birth, often referred to as birth defects.
- Causes include genetic factors (chromosomal aberrations), environmental factors during fetal development (maternal disease, infections, drugs), and rare intrauterine factors (fetal crowding).
Single Gene Disorders
- Result from a single defective or mutant gene.
Disorders of Autosomal Inheritance
- Autosomal dominant disorders require one altered gene copy for manifestation (e.g., Marfan syndrome).
- Autosomal recessive disorders need both gene copies to be altered (e.g., Sickle cell disease).
Disorders of Sex-Linked Inheritance
- Always associated with the X chromosome.
Chromosome Disorders
- Involve changes in chromosome number or structure, impacting genetic mechanisms or reproductive processes.
- Monosomy X (Turner's syndrome)
- Polysomy X (Klinefelter's syndrome)
- Trisomy 21 (Down's syndrome): Presence of a third copy of chromosome 21, linked to growth delays, intellectual disability, and characteristic facial features.
Neoplasia
- New, abnormal growth due to abnormal cellular reproduction, synonymous with "tumor."
Tumor Terminology
- Tumor: A mass of neoplastic cells clustered together.
- Benign tumor: Non-cancerous, often encapsulated, and less likely to spread.
- Malignant tumor: Cancerous, capable of invading surrounding tissues and metastasizing (spreading to other parts of the body).
- Promotion: Repeated exposure to promoting agents (co-carcinogens) leads to abnormal genetic expression.
- Progression: Cells exhibiting increased malignant behavior, invading adjacent tissues and metastasizing.
Pathophysiology of the Malignant Process
- Cancer initiates with an abnormal cell transformed by genetic mutation of cellular DNA.
- The abnormal cell proliferates abnormally and acquires invasive characteristics, altering surrounding tissues.
- Cells infiltrate tissues and gain access to lymph and blood vessels, leading to metastasis.
Methods of Cancer Spread
- Direct invasion and extension: Cancer cells directly invade and extend into nearby tissues.
- Seeding of cancer cells in body cavities: Cancer cells spread within body cavities (e.g., peritoneal cavity).
- Metastatic spread through blood or lymph pathways: Cancer cells travel via the bloodstream or lymphatic system to distant sites.
Tumor Staging and Grading
-
Staging assesses tumor size and the presence of metastasis using the TNM system:
- T (tumor): Extent of the primary tumor.
- N (node): Lymph node involvement.
- M (metastasis): Extent of metastasis.
- Grading classifies the aggressiveness of the tumor based on its cellular appearance and behavior.
TNM Classification System
-
T (Primary Tumor):
- Tx: Cannot be assessed.
- T0: No evidence.
- Tis: Carcinoma in situ (in place).
- T1, T2, T3, T4: Increasing size and/or local extent.
-
N (Regional Lymph Nodes)
- Nx: Cannot be assessed.
- N0: No regional lymph node metastasis.
- N1, N2, N3: Increasing involvement of regional lymph nodes.
-
M (Distant Metastasis)
- Mx: Cannot be assessed.
- M0: No distant metastasis.
- M1: Distant metastasis.
Clinical Manifestations of Cancer
- Tissue Integrity: Compressed and eroded blood vessels, ulceration, necrosis, bleeding, and hemorrhage.
- Cancer Cachexia: Weight loss, wasting of body fat and muscle tissue, profound weakness, anorexia, and anemia.
- Paraneoplastic Syndromes: Inappropriate hormone release, circulating hematopoietic, neurological, and dermatological factors.
Diagnostic Measures for Cancer Detection
- Screening: Early detection.
- Lab tests: Blood tests, urine tests, etc.
- Biopsy: Removal of tissue for microscopic examination.
- Endoscopic examinations: Visual examination of internal organs.
- Imaging studies: Ultrasound, X-ray, MRI, CT, PET scans.
- Tumor markers: Substances produced by cancer cells that can be detected in blood or other bodily fluids.
Treatment Options
- Surgery: Removal of the tumor and surrounding tissues.
- Chemotherapy: Use of anticancer drugs to kill cancer cells.
- Radiation therapy: Use of high-energy radiation to kill cancer cells.
- Hormone therapy: Use of hormones to alter the growth of cancer cells.
- Immunotherapy: Use of the body's immune system to fight cancer cells.
- Palliative treatment: Treatment designed to relieve symptoms and improve quality of life.
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Description
Explore the adaptive changes cells undergo to manage stimuli and the genetic control of cell function and inheritance. This quiz covers key concepts regarding somatic and germ cells, their reproduction mechanisms, and factors causing genetic disorders. Test your understanding of how cells maintain homeostasis and the impact of genetics on cell function.
