Podcast
Questions and Answers
What type of receptor directly phosphorylates and activates a member of the Smad class of TFs?
What type of receptor directly phosphorylates and activates a member of the Smad class of TFs?
- Receptors for TGF-beta family of signaling proteins (correct)
- Receptors for Wnt proteins
- Receptors for notch family of receptors
- GPCRs
Which signaling pathway involves the release of its cytosolic domain into the nucleus to regulate gene expression?
Which signaling pathway involves the release of its cytosolic domain into the nucleus to regulate gene expression?
- Pathway A: GPCRs
- Pathway B: TGF-beta family of signaling proteins
- Pathway C: notch family of receptors (correct)
- Pathway D: Wnt, hedgehog, IL
What is the key signaling molecule in the canonical Wnt pathway?
What is the key signaling molecule in the canonical Wnt pathway?
- Smad
- G protein
- TF TCF
- Beta-catenin (correct)
What regulates the stability of beta-catenin in the canonical Wnt pathway?
What regulates the stability of beta-catenin in the canonical Wnt pathway?
What induces phosphorylation of LRP cytosolic domain in the canonical Wnt pathway?
What induces phosphorylation of LRP cytosolic domain in the canonical Wnt pathway?
What happens to beta-catenin in the absence of Wnt signal in the canonical Wnt pathway?
What happens to beta-catenin in the absence of Wnt signal in the canonical Wnt pathway?
What can provide identity to cells and tissues in a highly specific manner?
What can provide identity to cells and tissues in a highly specific manner?
What can influence the expression of downstream TFs?
What can influence the expression of downstream TFs?
What is responsible for the proper patterning, growth, and overall development of tissues and organs?
What is responsible for the proper patterning, growth, and overall development of tissues and organs?
What activates the expression of a reporter gene in limb buds of developing mouse embryos?
What activates the expression of a reporter gene in limb buds of developing mouse embryos?
What can lead to activation of TFs?
What can lead to activation of TFs?
What binds to phosphorylated residues on beta-catenin leading to its ubiquitination and degradation?
What binds to phosphorylated residues on beta-catenin leading to its ubiquitination and degradation?
What is the function of the UAS/GAL4 system in the context of gene expression?
What is the function of the UAS/GAL4 system in the context of gene expression?
What is the role of the enhancer region in gene transcription?
What is the role of the enhancer region in gene transcription?
What is the consequence of Pax6 expression in a fly?
What is the consequence of Pax6 expression in a fly?
What is the evolutionary conservation pattern of eye gene regulatory network (GRN) between mouse Pax6 and Drosophila ey?
What is the evolutionary conservation pattern of eye gene regulatory network (GRN) between mouse Pax6 and Drosophila ey?
What is the significance of the conserved region containing an enhancer in the context of gene expression?
What is the significance of the conserved region containing an enhancer in the context of gene expression?
What is the role of the Pax6 gene in the development of various tissues?
What is the role of the Pax6 gene in the development of various tissues?
What is the consequence of GAL4 driven ectopic expression of ey in various tissues?
What is the consequence of GAL4 driven ectopic expression of ey in various tissues?
What is the role of orthologs of developmental genes like SALL1 in appendage development?
What is the role of orthologs of developmental genes like SALL1 in appendage development?
What is the role of the TFs in the context of gene expression in developing brain cells?
What is the role of the TFs in the context of gene expression in developing brain cells?
What is the consequence of the expression of mouse Pax6 in a fly?
What is the consequence of the expression of mouse Pax6 in a fly?
What is the function of the double negative logic circuit in gene expression?
What is the function of the double negative logic circuit in gene expression?
