Podcast
Questions and Answers
Which of the following molecules requires a carrier protein to cross the cell membrane?
Which of the following molecules requires a carrier protein to cross the cell membrane?
- Urea
- Oxygen (O2)
- Glucose (correct)
- Carbon Dioxide (CO2)
What primarily drives the movement of oxygen (O2) into cells?
What primarily drives the movement of oxygen (O2) into cells?
- A higher concentration of O2 outside the cell (correct)
- The cell's energy consumption
- Active transport mechanisms
- Lower concentration of O2 outside the cell
Which of the following correctly describes the movement of carbon dioxide (CO2) across the cell membrane?
Which of the following correctly describes the movement of carbon dioxide (CO2) across the cell membrane?
- It moves passively into the cell.
- It moves out of the cell via active transport.
- It diffuses out of the cell due to higher intracellular concentration. (correct)
- It requires carrier proteins for facilitated diffusion into the cell.
What is a key characteristic of lipid-soluble substances in relation to diffusion across the cell membrane?
What is a key characteristic of lipid-soluble substances in relation to diffusion across the cell membrane?
Which of the following is a key characteristic of protein channels on the cell membrane?
Which of the following is a key characteristic of protein channels on the cell membrane?
What does 'voltage gating' in the context of cell membrane protein channels refer to?
What does 'voltage gating' in the context of cell membrane protein channels refer to?
A cell at rest has a strong negative charge inside the membrane. How does this affect the sodium (Na) gates in the cell membrane?
A cell at rest has a strong negative charge inside the membrane. How does this affect the sodium (Na) gates in the cell membrane?
Which type of transport mechanism does not require energy from the cell?
Which type of transport mechanism does not require energy from the cell?
What is primarily responsible for the depolarization phase of an action potential?
What is primarily responsible for the depolarization phase of an action potential?
What best describes the state of the cell membrane interior immediately after an action potential is initiated?
What best describes the state of the cell membrane interior immediately after an action potential is initiated?
Which of the following is responsible for the repolarization phase of an action potential?
Which of the following is responsible for the repolarization phase of an action potential?
How do chemically gated channels function?
How do chemically gated channels function?
What is the effect of acetylcholine binding to its channel?
What is the effect of acetylcholine binding to its channel?
What is facilitated diffusion primarily used for?
What is facilitated diffusion primarily used for?
Which of the following is an example of facilitated diffusion described in the text?
Which of the following is an example of facilitated diffusion described in the text?
Which of the following best describes voltage-gated potassium channels?
Which of the following best describes voltage-gated potassium channels?
Which type of transport uses the energy stored in an ion concentration gradient to move another molecule against its own concentration gradient?
Which type of transport uses the energy stored in an ion concentration gradient to move another molecule against its own concentration gradient?
Which cellular process involves the secretion of hormones and neurotransmitters from the cell?
Which cellular process involves the secretion of hormones and neurotransmitters from the cell?
What is the primary function of a phagosome?
What is the primary function of a phagosome?
Which type of endocytosis is considered non-selective and involves the intake of extracellular fluid?
Which type of endocytosis is considered non-selective and involves the intake of extracellular fluid?
A cell engulfs a clump of bacteria using pseudopods. What is this process called?
A cell engulfs a clump of bacteria using pseudopods. What is this process called?
In secondary active transport, what is the role of ATP?
In secondary active transport, what is the role of ATP?
What is the main difference between pinocytosis and phagocytosis?
What is the main difference between pinocytosis and phagocytosis?
Which process is the reverse of exocytosis?
Which process is the reverse of exocytosis?
What is the main purpose of the sodium-potassium pump in nerve cells?
What is the main purpose of the sodium-potassium pump in nerve cells?
How many sodium ions does the Na+/K+ pump move out of the cell for each ATP molecule used?
How many sodium ions does the Na+/K+ pump move out of the cell for each ATP molecule used?
Which other primary active transport mechanism is mentioned, apart from the sodium-potassium pump?
Which other primary active transport mechanism is mentioned, apart from the sodium-potassium pump?
What characteristic of the intracellular concentration of calcium ions is emphasized?
What characteristic of the intracellular concentration of calcium ions is emphasized?
Where in the body is the active transport of hydrogen ions particularly important?
Where in the body is the active transport of hydrogen ions particularly important?
What is the function of the SERCA pumps mentioned?
What is the function of the SERCA pumps mentioned?
In nerve cells, the inside of the cell has what sort of electrical charge relative to the outside?
In nerve cells, the inside of the cell has what sort of electrical charge relative to the outside?
What drives the secondary active transport process when a molecule moves down its concentration gradient?
What drives the secondary active transport process when a molecule moves down its concentration gradient?
What is the primary reason glucose cannot cross the lipid bilayer via simple diffusion?
What is the primary reason glucose cannot cross the lipid bilayer via simple diffusion?
What is the function of glucose transporters (GLUTs) in facilitated diffusion?
What is the function of glucose transporters (GLUTs) in facilitated diffusion?
What is the role of insulin in glucose transport in skeletal muscle, heart, and adipose tissue?
What is the role of insulin in glucose transport in skeletal muscle, heart, and adipose tissue?
Which of the following is NOT a characteristic of osmosis?
Which of the following is NOT a characteristic of osmosis?
What is the term used to describe two solutions with the same concentration of solutes?
What is the term used to describe two solutions with the same concentration of solutes?
What would happen to a red blood cell placed in a solution with a higher concentration of solutes than the cell's cytoplasm?
What would happen to a red blood cell placed in a solution with a higher concentration of solutes than the cell's cytoplasm?
Which of these is NOT a characteristic of facilitated diffusion?
Which of these is NOT a characteristic of facilitated diffusion?
What is the primary function of the heart in the context of filtration?
What is the primary function of the heart in the context of filtration?
Which of the following is a key difference between passive and active transport?
Which of the following is a key difference between passive and active transport?
What is the normal NaCl concentration inside a human red blood cell?
What is the normal NaCl concentration inside a human red blood cell?
What is an example of active transport listed in the content?
What is an example of active transport listed in the content?
Which transport method involves the direct hydrolysis of ATP?
Which transport method involves the direct hydrolysis of ATP?
What is the role of ATP in active transport?
What is the role of ATP in active transport?
What type of transport utilizes protein carriers to assist movement across membranes?
What type of transport utilizes protein carriers to assist movement across membranes?
In secondary active transport, how is the energy generated?
In secondary active transport, how is the energy generated?
What characterizes the antiport mechanism in active transport?
What characterizes the antiport mechanism in active transport?
Flashcards
Simple diffusion
Simple diffusion
The movement of molecules across a cell membrane from an area of high concentration to an area of low concentration, without the need for energy.
Facilitated diffusion
Facilitated diffusion
The movement of molecules across a cell membrane from an area of high concentration to an area of low concentration with the assistance of carrier proteins.
Active transport
Active transport
The process by which cells use energy to move molecules against their concentration gradient, from an area of low concentration to an area of high concentration.
Lipid solubility
Lipid solubility
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Protein channels
Protein channels
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Voltage gating
Voltage gating
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Ligand gating
Ligand gating
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Mechanical gating
Mechanical gating
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Depolarization
Depolarization
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Sodium Channel Opening
Sodium Channel Opening
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Repolarization
Repolarization
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Potassium Channel Opening
Potassium Channel Opening
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Chemical (Ligand) Gating
Chemical (Ligand) Gating
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Facilitated Diffusion of Glucose
Facilitated Diffusion of Glucose
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Glucose Transport
Glucose Transport
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Osmosis
Osmosis
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Isotonic
Isotonic
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Osmosis in Red Blood Cells
Osmosis in Red Blood Cells
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Passive Transport
Passive Transport
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Semipermeable Membrane
Semipermeable Membrane
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Primary Active Transport
Primary Active Transport
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Secondary Active Transport
Secondary Active Transport
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Uniport
Uniport
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Symport
Symport
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Antiport
Antiport
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Sodium-Potassium Pump
Sodium-Potassium Pump
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Electrical Gradient
Electrical Gradient
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Calcium Pump
Calcium Pump
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Gastric H+-ATPase
Gastric H+-ATPase
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Kidney H+-ATPase
Kidney H+-ATPase
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Concentration Gradient
Concentration Gradient
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Vesicular Transport
Vesicular Transport
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Exocytosis
Exocytosis
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Endocytosis
Endocytosis
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Phagocytosis
Phagocytosis
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Pinocytosis
Pinocytosis
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Receptor-mediated Endocytosis
Receptor-mediated Endocytosis
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Lysosomes
Lysosomes
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Study Notes
Cell Membrane Transport
- The cell membrane regulates material entry and exit, crucial for maintaining homeostasis.
- The cell membrane's ability to regulate the concentration of substances inside the cell is a vital function.
- The membrane is selectively permeable, allowing some substances to cross but not others.
Membrane Permeability to Ions
- Cell membranes are impermeable to negatively charged large molecules (e.g., proteins, phosphate groups of ATP) at rest.
- Permeability to K+ ions is significantly higher (25-75 times) than Na+ ions.
- Permeability to Cl- ions is greater than both Na+ and K+ ions.
- Ion channel quantities influence ion permeability across the membrane.
- Membranes have more K+ leakage channels and fewer Na+ leakage channels.
Intracellular and Extracellular Distributions of Ions
- Extracellular fluids predominantly contain sodium and chloride ions.
- Intracellular fluids mainly contain potassium ions and proteins with negatively charged side chains.
Factors Affecting Rate of Diffusion
- Fick's laws describe diffusion.
- The rate of diffusion is proportional to the concentration gradient, the diffusion pathway length, and the available surface area.
Diffusion Across the Cell Membrane
- Simple diffusion: Molecules move directly across the membrane without carrier proteins.
- Hydrophobic molecules (e.g., O2, CO2) and small uncharged polar molecules (e.g., urea) use this method.
- Facilitated diffusion: Larger uncharged polar molecules (e.g., glucose), and charged molecules (ions) require carrier proteins.
Diffusion of Lipid-Soluble Substances
- Lipid solubility significantly impacts how readily a substance diffuses through the lipid bilayer.
- Substances with high lipid solubility (e.g., oxygen, nitrogen, carbon dioxide, alcohols) readily dissolve in the lipid bilayer and diffuse through the membrane.
- Diffusion rate is directly proportional to lipid solubility.
Diffusion Through Protein Channels
- Protein channels in the cell membrane are often selectively permeable to specific substances.
- Many channels can be opened or closed by gates.
Gating of Channels
- Voltage gating: Gate conformation changes in response to electrical potential across the membrane.
- Strong negative charge inside the cell (resting state) keeps Na+ gates closed.
- Inside loses negative charge, Na+ gates open.
- Chemical (ligand) gating: The binding of a chemical substance (ligand) with a protein causes a conformational change opening or closing the gate.
- Acetylcholine binding is an example impacting sodium channels
Facilitated Diffusion
- Large polar or ionic molecules are typically hydrophilic.
- They cannot readily cross the phospholipid bilayer.
- Facilitated diffusion uses membrane proteins to transport large polar/ionic molecules across.
- Glucose is a prime example of facilitated diffusion—using a specific glucose transporter.
Osmosis
- Osmosis: Water moves across a semipermeable membrane from an area of lower solute concentration to an area of higher solute concentration.
- The goal is to equalize solute concentrations across the membrane.
Tonicity
- Isotonic: Solute concentration is equal inside and outside the cell; water movement is balanced.
- Hypertonic: Solute concentration is higher outside the cell; water moves out, causing cell shrinkage (crenation).
- Hypotonic: Solute concentration is lower outside the cell; water moves in, causing cell swelling (potentially lysis).
Filtration
- Filtration: Materials are forced through a membrane by hydrostatic pressure.
- This process is important in the body for fluid movement through capillary walls and in the kidneys for glomerular filtration.
Active Transport
- Active transport requires energy (ATP) to move substances against their concentration gradient.
- Uniport: Pumps one molecule across the membrane.
- Symport: Pumps two molecules in the same direction.
- Antiport: Pumps two molecules in opposite directions
Vesicular Transport
-
Includes endocytosis (bringing substances into the cell) and exocytosis (releasing substances from the cell).
- Endocytosis: Includes Phagocytosis (cell eating), Pinocytosis (cell drinking), receptor-mediated endocytosis.
- Exocytosis: Used for secretion and waste removal.
Specific Active Transport Mechanisms
- Sodium-Potassium Pump (Na+/K+ ATPase): Maintains ion concentration gradients crucial for nerve and muscle function.
- Calcium Pump (SERCA): Keeps intracellular calcium low by pumping Ca2+ ions against their concentration gradient into the endoplasmic reticulum or other storage sacs.
- Hydrogen Pump (Gastric H+ ATPase): Involved in stomach acid production and regulation.
Secondary Active Transport
- This process relies on an existing electrochemical concentration gradient of one substance to drive the transport of another substance against its own concentration gradient.
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