12 Questions
What is the primary function of occluding junctions in epithelial cells, and what are the two proteins involved in forming sealing strands?
The primary function of occluding junctions is to seal cells together to prevent apical and basolateral mixing and confine transport of molecules to appropriate receptors and transporters. The two proteins involved in forming sealing strands are Claudin and Occludin.
What is the difference between adherens junctions and desmosomes, and what type of filaments are they based on?
Adherens junctions are cell-cell junctions, while desmosomes are also cell-cell junctions. Both are based on actin filaments.
What is the role of intermediate filaments in anchoring junctions, and what type of proteins do they bind to?
Intermediate filaments bind to dense plaques and are involved in anchoring junctions. They bind to keratinous filaments.
What is the function of gap junctions, and in which organisms are they found?
Gap junctions are communicating junctions that allow for the direct exchange of ions and molecules between adjacent cells. They are found in animals, including vertebrates and invertebrates, as well as in plants (known as plasmodesmata).
What is the role of myosin II in actin filament-based anchoring junctions, and how does it bind to actin?
Myosin II binds to actin in an ATP-dependent manner to form filaments, playing a crucial role in actin filament-based anchoring junctions.
What is the role of focal adhesions and hemidesmosomes in anchoring junctions, and what type of proteins do they use to link cells to the ECM?
Focal adhesions are cell-matrix junctions, while hemidesmosomes are also cell-matrix junctions. Both use integrins to link cells to the ECM.
What are the components of desmosomes that are composed of desmoglein and desmocollin?
Cadherins
Which type of cell adhesion junctions are characterized as permanent?
Cell junctions
What is the function of hemidesmosomes?
Connect intermediate filaments to ECM
What signaling pathway is involved in linking cells via N-CAM?
Rac1, GDI, PI3K, GEF
Which cell adhesion molecules are responsible for the transition from ectoderm to neural tube?
Cadherins
What type of proteins are Selectins and what types exist in the human body?
Carbohydrate binding proteins; L-selectin, P-selectin, E-selectin
Test your knowledge on cell junctions, including desmosomes, focal adhesions, and hemidesmosomes, as well as cell adhesions. Learn about the components of different types of junctions and their functions in connecting cells and extracellular matrix.
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