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Questions and Answers

What occurs when cells are unable to adapt to physiological stresses and pathological stimuli?

  • Cell repair
  • Cell injury (correct)
  • Cell death
  • Cellular adaptation

What is a characteristic of reversible cell injury?

  • Permanent membrane damage
  • Severe nucleus damage
  • No membrane damage and intact nucleus (correct)
  • Rapid cell death

What is the outcome of severe, persistent, and rapid stress to a cell?

  • Irreversible cell injury (correct)
  • Cell adaptation
  • Reversible cell injury
  • Cell hypertrophy

What is the result of removing the damaging stimulus from a cell with reversible injury?

<p>Cell returns to a stable state (D)</p> Signup and view all the answers

What is the difference between reversible and irreversible cell injury?

<p>Severity of stress (B)</p> Signup and view all the answers

What is the goal of cellular adaptations in response to physiological stresses and pathological stimuli?

<p>To achieve a new steady state and preserve viability and function (B)</p> Signup and view all the answers

What is the primary site of membrane damage during cell injury?

<p>Mitochondrial membrane (C)</p> Signup and view all the answers

What is a consequence of severe DNA damage to a cell?

<p>Cell death by apoptosis (D)</p> Signup and view all the answers

What is a common cause of DNA damage?

<p>Radiation and chemical injury (B)</p> Signup and view all the answers

What is a factor that can lead to defects in membrane permeability?

<p>Hypoxia (B)</p> Signup and view all the answers

What is a result of increased reactive oxygen species (ROS)?

<p>Lipid peroxidation (B)</p> Signup and view all the answers

What is a consequence of mitochondrial injury?

<p>ATP depletion leading to necrosis (C)</p> Signup and view all the answers

What is the consequence of continuous injurious stimuli to cells?

<p>Irreversible cell injury (C)</p> Signup and view all the answers

What is the most common cause of oxygen deprivation mentioned in the text?

<p>Hypoxia (C)</p> Signup and view all the answers

What is the primary target of injurious stimuli in cells?

<p>Mitochondria (B)</p> Signup and view all the answers

What is the main cause of necrotic cell death?

<p>ATP depletion (C)</p> Signup and view all the answers

What determines the consequences of cell injury?

<p>Type, state, and adaptability of injured cell (C)</p> Signup and view all the answers

What is the result of ATP depletion in cells?

<p>Necrotic cell death (B)</p> Signup and view all the answers

What is the result of sodium pump failure in the mechanism of ischemic/hypoxic injury?

<p>Influx of Ca2+, Na+, and H2O (C)</p> Signup and view all the answers

What is the consequence of increased cytosolic Ca+2 in the mechanism of cell injury?

<p>Activation of enzymes that damage cells (C)</p> Signup and view all the answers

What is the result of mitochondrial injury in the mechanism of cell injury?

<p>Formation of channels in the mitochondrial membrane (A)</p> Signup and view all the answers

What is the effect of anaerobic glycolysis in the mechanism of ischemic/hypoxic injury?

<p>Accumulation of lactic acid causing low pH (C)</p> Signup and view all the answers

What is the result of the influx of oxygen-derived free radicals in the mechanism of cell injury?

<p>Damaging cell organelles (D)</p> Signup and view all the answers

What is the consequence of ATP depletion in the mechanism of ischemic/hypoxic injury?

<p>Cellular and ER swelling, mitochondria swelling (A)</p> Signup and view all the answers

What is the primary cause of cellular swelling in reversible cell injury?

<p>Loss of Na+ K+ ATPase pump activity (D)</p> Signup and view all the answers

What is the characteristic feature of hydropic changes in reversible cell injury?

<p>Pinched off segments of ER, appearing as small clear vacuoles within cytoplasm (D)</p> Signup and view all the answers

Which organelle is affected by water accumulation, leading to swelling in reversible cell injury?

<p>Mitochondria (A)</p> Signup and view all the answers

What is the term for the appearance of lipid-filled vacuoles in cytoplasm in reversible cell injury?

<p>Fatty changes (A)</p> Signup and view all the answers

Which of the following organs is commonly affected by fatty changes in reversible cell injury?

<p>Kidney (C)</p> Signup and view all the answers

What is the result of detachment of polysomes from ER in reversible cell injury?

<p>Inhibition of protein synthesis (D)</p> Signup and view all the answers

What is the primary site of ATP generation that is affected by injurious stimuli?

<p>Mitochondria (D)</p> Signup and view all the answers

What is the most common cause of oxygen deprivation mentioned in the text?

<p>Hypoxia (B)</p> Signup and view all the answers

What is the consequence of ATP depletion in the mechanism of cell injury?

<p>Necrotic cell death (C)</p> Signup and view all the answers

What determines the consequences of cell injury?

<p>Type, state, and adaptability of the injured cell (C)</p> Signup and view all the answers

What is the result of injurious stimuli on cell membranes?

<p>Disruption of homeostasis (A)</p> Signup and view all the answers

What is the role of mitochondria in the mechanism of cell injury?

<p>ATP generation (A)</p> Signup and view all the answers

What is the result of continuous injurious stimuli to cells?

<p>Cell death (C)</p> Signup and view all the answers

What is the primary target of injurious stimuli in cells?

<p>Mitochondria (C)</p> Signup and view all the answers

What is the consequence of reduced supply of oxygen in the mechanism of cell injury?

<p>ATP depletion (A)</p> Signup and view all the answers

What is the result of toxins in the mechanism of cell injury?

<p>ATP depletion (C)</p> Signup and view all the answers

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